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FUS Gene Amyotrophic Lateral Sclerosis Type 6 NGS Genetic Test

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FUS Gene Amyotrophic Lateral Sclerosis Type 6 NGS Genetic Test

Short Name: FUS Gene ALS6 NGS Test

Also known as: FUS Gene Mutation Test, ALS Type 6 Genetic Test, FUS NGS Sequencing

FUS Gene Amyotrophic Lateral Sclerosis Type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are expected within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify disease-causing mutations in the FUS gene, confirming or ruling out ALS type 6. It provides valuable information for diagnosis, prognosis, and genetic counselling for patients and families.

Test Code
3890
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are expected within 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. A prior genetic counselling session is advised to draw a pedigree chart and understand the implications of the test.

Method: Peripheral blood draw, dried blood spot, or DNA submission

Step 2

Laboratory Analysis

For blood sample, a trained phlebotomist will draw blood from an arm vein. For FTA card, a finger or heel prick may be used. The process is simple and quick.

Step 3

Report Delivery

There are no restrictions after sample collection. You can resume daily activities immediately. The sample is safely transported to the lab for analysis.

Timeline: Reports are expected within 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Review your family history with a genetic counsellor. No fasting needed. Prepare a list of current medications and symptoms.
2
During the Test:The sample collection is quick. You may feel a brief pinch during blood draw. Inform the technician if you have a history of bleeding.
3
After the Test:You can leave the collection site immediately. There is no recovery time needed. Your sample will be processed and results will be shared when ready.

About This Test

Who Should Get This Test

The purpose of this test is to identify disease-causing mutations in the FUS gene, confirming or ruling out ALS type 6. It provides valuable information for diagnosis, prognosis, and genetic counselling for patients and families.

How to Prepare

  • Informed consent must be signed before sample collection
  • Provide relevant clinical history and family pedigree
  • Ensure correct patient identification on the sample

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"FUS gene testing using next-generation sequencing is a reliable method for confirming the genetic cause in suspected ALS type 6 patients. The results guide prognosis and enable informed family counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for selected sample type
ContainerEDTA tube / FTA card / DNA vial
Collection MethodPeripheral blood draw, dried blood spot, or DNA submission

Sample Stability

Whole blood: 4-8 hours at room temperature
Extracted DNA: stable for months at -20°C
FTA card: stable for weeks at room temperature
Sample Rejection Criteria:
  • Clotted or haemolysed blood sample
  • Insufficient sample quantity
  • Incorrectly labelled samples
  • Sample without clinical history or consent

Understanding Your Results

The NGS test analyses the FUS gene for sequence variants associated with ALS type 6. The clinical report should be interpreted by a clinical geneticist or neurologist experienced in neuromuscular disorders.
Positive: Pathogenic or likely pathogenic variant identified in FUS gene confirms the diagnosis of ALS type 6 and enables targeted family counselling.
Negative: No clinically significant variant found; ALS may be caused by other genetic or non-genetic factors.
VUS: Variant of uncertain significance found; additional familial segregation analysis is recommended.
⚠️ When to Consult a Doctor:

If you or a relative have symptoms suggestive of ALS, or there is a known family history of FUS-related ALS, consult a neurologist or genetic counsellor to determine if this test is appropriate.

Limitations

  • ⚠Standard NGS does not detect large structural rearrangements, repeat expansions, or deep intronic variants
  • ⚠A negative result does not exclude ALS caused by mutations in other genes
  • ⚠Variant of uncertain significance may require additional family testing

Risks & Considerations

  • ●Minimal risk of bruising or discomfort at the blood draw site
  • ●Rare possibility of infection at the puncture site
  • ●Emotional or psychological impact of genetic test results

Interfering Factors

  • ●Paucity or degradation of DNA
  • ●Maternal cell contamination
  • ●Presence of large copy number variants not detectable by standard NGS
  • ●Mislabeling of sample

Compare With Similar Tests

TestFUS Gene Amyotrophic Lateral Sclerosis Type 6 NGS Genetic Test
ComparisonFUS Gene Amyotrophic Lateral Sclerosis Type 6 NGS Genetic Test

Frequently Asked Questions

What is the FUS gene and its role in ALS?
The FUS gene provides instructions for making the FUS protein, which is involved in RNA processing and DNA repair. Mutations in this gene are associated with ALS type 6, leading to motor neuron degeneration.
Who should consider this FUS gene NGS test?
Individuals with symptoms of ALS such as progressive muscle weakness, twitching, or family history of ALS; or those who have undergone genetic counselling and need confirmation of diagnosis.
What is the cost of the test?
The FUS Gene ALS Type 6 NGS Genetic Test at DNA Labs India costs INR 20000, including genetic counselling and home sample collection.
What sample is required?
The test can be performed on blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required?
No, fasting is not required for this genetic test.
How is the test performed?
The test uses next-generation sequencing technology to analyze the entire FUS gene for mutations.
What does a positive or negative result mean?
A positive result indicates the presence of a pathogenic/likely pathogenic variant in the FUS gene confirming ALS type 6. A negative result means no such mutation was found, but does not exclude other forms of ALS.
Can this test be done before symptoms appear?
Yes, presymptomatic testing can be considered in adults at high genetic risk after proper genetic counselling and informed consent.
Are there any risks?
Risks are minimal. Blood collection may cause mild discomfort, bruising, or rarely infection.
Is home sample collection available?
Yes, DNA Labs India provides free home sample collection for online bookings in over 100 cities.
What are the limitations of this test?
NGS may not detect large deletions, repeat expansions, or deep intronic variants. A negative report does not rule out ALS caused by other genes.
When will I get my report?
Test reports are delivered in 3 to 4 weeks. You will receive the clinical report along with raw data files (FASTQ, VCF) as requested.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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