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GAD1 Gene Cerebral Palsy Type 1, Spastic Quadriplegic NGS Genetic Test

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GAD1 Gene Cerebral Palsy Type 1, Spastic Quadriplegic NGS Genetic Test

Short Name: GAD1 NGS Test

Also known as: GAD1 Gene Sequencing, GAD1 Genetic Test, Spastic Quadriplegic Cerebral Palsy NGS Panel, GAD1-Related Cerebral Palsy DNA Test

GAD1 Gene Cerebral Palsy Type 1, Spastic Quadriplegic NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger confirmation of detected variants on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify pathogenic variants in the GAD1 gene associated with cerebral palsy type 1, spastic quadriplegic, and to support clinical diagnosis, recurrence risk counselling and informed management.

Test Code
3951
ICD Code
G80.0
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS), Sanger confirmation of detected variants
Step 1

Sample Collection

No fasting is required. A genetic counselling session is recommended before testing to collect a detailed family history and discuss the benefits and limitations.

Method: Venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample or prepare an FTA card blood spot. The procedure takes a few minutes.

Step 3

Report Delivery

There are no movement or diet restrictions. The sample will be sent to the genetics laboratory for NGS analysis.

Timeline: Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.

Patient Instructions

1
Before the Test:No fasting is required. Complete genetic counselling and informed consent are advised before sample collection.
2
During the Test:The laboratory will extract DNA from the sample and perform targeted NGS for the GAD1 gene.
3
After the Test:The final report will include variant interpretation and clinical recommendations.

About This Test

Who Should Get This Test

To identify pathogenic variants in the GAD1 gene associated with cerebral palsy type 1, spastic quadriplegic, and to support clinical diagnosis, recurrence risk counselling and informed management.

How to Prepare

  • Blood should be collected in an EDTA vacutainer and gently mixed.
  • If using an FTA card, apply one drop of blood to each marked circle and allow it to air dry.
  • Write the patient's name and date on the sample label.
  • Ship the sample at ambient temperature to the laboratory within 24 hours.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"In cerebral palsy without an obvious acquired cause, genetic testing can provide important information about cause, recurrence risk and future care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required by laboratory protocol
ContainerEDTA vacutainer / FTA card
Collection MethodVenipuncture or FTA card blood spot

Sample Stability

EDTA whole blood: 2-8°C for up to 48 hours
Extracted DNA: -20°C for up to 6 months
FTA card: Room temperature for up to 4 weeks
Sample Rejection Criteria:
  • Clotted EDTA sample
  • Insufficient sample quantity
  • Visible haemolysis
  • Unlabelled or mislabelled sample
  • Sample exposed to extreme temperature

Understanding Your Results

The GAD1 gene NGS test is qualitative. The result is reported as positive, negative or variant of uncertain significance, using ACMG guidelines and correlation with the patient's clinical phenotype.
📊

Pathogenic/likely pathogenic variant detected in GAD1

Supports molecular diagnosis of GAD1-related cerebral palsy type 1. Family counselling and segregation testing recommended.

📊

No pathogenic variant detected in GAD1

Reduces likelihood of GAD1-related disorder, but does not exclude all causes of cerebral palsy.

📊

VUS detected in GAD1

Additional segregation studies and phenotype correlation are needed to determine clinical significance.

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist if the test is positive, if a variant of uncertain significance is reported, or if you have questions about management and recurrence risk.

Limitations

  • ⚠This is a targeted gene test, not a comprehensive cerebral palsy panel.
  • ⚠Large deletions, duplications, repeat expansions or deep intronic variants may not be detected by standard NGS.
  • ⚠A negative result does not exclude a genetic or non-genetic cause.
  • ⚠Variant classification may change as new evidence emerges.

Risks & Considerations

  • ●Minimal risk of bleeding or hematoma at the venipuncture site
  • ●Dizziness or vasovagal response during blood draw
  • ●Psychological implications of a genetic test result

Interfering Factors

  • ●Insufficient DNA quantity or quality
  • ●Sample contamination during collection or handling
  • ●Recent allogeneic bone marrow transplant
  • ●Improper storage or transport conditions

Compare With Similar Tests

TestGAD1 Gene Cerebral Palsy Type 1, Spastic Quadriplegic NGS Genetic Test
ComparisonGAD1 Gene Cerebral Palsy Type 1, Spastic Quadriplegic NGS Genetic Test

Frequently Asked Questions

What is the GAD1 gene cerebral palsy type 1 spastic quadriplegic NGS genetic test?
It is a targeted next-generation sequencing test that examines the GAD1 gene for pathogenic variants associated with cerebral palsy type 1, spastic quadriplegic.
How much does the GAD1 gene NGS genetic test cost at DNA Labs India?
The test costs INR 20,000. DNA Labs India also provides free home sample collection for online bookings.
What sample is needed for this genetic test?
The test can be done using blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this test.
When will I get the report?
Reports are usually available within 3 to 4 weeks from the date the sample is received by the laboratory.
Is home sample collection available?
Yes, free home sample collection is available across many cities in India for this test.
Will I receive raw data files?
Yes, DNA Labs India provides raw data, FASTQ and VCF files along with the clinical report.
Who should take this test?
It is recommended for individuals with clinical features of spastic quadriplegic cerebral palsy of unknown cause, a family history of cerebral palsy, or when a genetic cause is suspected.
What does a positive result mean?
A positive result means a pathogenic or likely pathogenic variant was found in the GAD1 gene, supporting a molecular diagnosis of GAD1-related cerebral palsy type 1.
What does a negative result mean?
A negative result means no pathogenic variant was detected in the GAD1 gene, but it does not rule out other genetic or non-genetic causes.
Can this test detect all genetic causes of cerebral palsy?
No. This test is specific to the GAD1 gene only. Broader panels or whole exome sequencing may be needed if another genetic cause is suspected.
Is genetic counselling included with the test?
Yes, a pre-test genetic counselling session is part of the test process to document family history and ensure informed consent.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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