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GBA Gene Lewy body dementia, susceptibility to NGS Genetic Test

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GBA Gene Lewy body dementia, susceptibility to NGS Genetic Test

Short Name: GBA Gene LBD Susceptibility Test

Also known as: GBA Mutation Test for LBD, Lewy Body Dementia Genetic Susceptibility Test, GBA Sequencing Test

GBA Gene Lewy body dementia, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks hours. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the GBA gene that increase susceptibility to Lewy Body Dementia.

Test Code
1658
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks hours
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

A genetic counseling session is recommended to discuss family history, implications of testing, and draw a pedigree chart.

Method: Blood Draw or FTA Card Application

Step 2

Laboratory Analysis

Standard blood draw procedure; for FTA card, apply one drop of blood as per instructions.

Step 3

Report Delivery

Sample is labeled and sent to the laboratory for DNA extraction and NGS analysis.

Patient Instructions

1
Before the Test:Genetic counseling and informed consent are required before sample collection.
2
During the Test:Blood sample collection or DNA extraction is performed at home or in a clinic.
3
After the Test:Results are analyzed using NGS technology and reported within 3-4 weeks.

About This Test

Who Should Get This Test

To identify mutations in the GBA gene that increase susceptibility to Lewy Body Dementia.

How to Prepare

  • Ensure proper patient identification and consent.
  • Use sterile equipment for blood collection.
  • For FTA card, follow manufacturer guidelines for blood application.
  • Store samples at ambient room temperature as specified.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic counseling is essential before and after testing to understand the implications of GBA mutations for Lewy Body Dementia risk and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood Draw or FTA Card Application

Sample Stability

Blood
Extracted DNA
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrect sample type or container
  • Unlabeled or improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the GBA gene that are associated with increased risk of Lewy Body Dementia.
📊

No pathogenic mutations detected

Lower genetic susceptibility to GBA-related Lewy Body Dementia; however, other factors may contribute to risk.

📊

Pathogenic mutation detected

Increased risk of developing Lewy Body Dementia; clinical monitoring and genetic counseling are recommended.

⚠️ When to Consult a Doctor:

If you have a family history of Lewy Body Dementia, are experiencing symptoms such as cognitive decline, hallucinations, or motor problems, or have received a positive genetic test result, consult a neurologist or genetic counselor.

Limitations

  • ⚠This test identifies genetic susceptibility but does not diagnose Lewy Body Dementia; clinical correlation is required.
  • ⚠May not detect all rare variants due to technical limitations of NGS.
  • ⚠Results should be interpreted in conjunction with family history and clinical evaluation.

Risks & Considerations

  • ●Psychological impact of genetic results
  • ●Potential for insurance or employment discrimination, though legal protections may apply in some regions

Interfering Factors

  • ●Hemolyzed blood samples
  • ●Insufficient DNA quantity
  • ●Sample contamination

Frequently Asked Questions

What is the GBA gene and how is it related to Lewy Body Dementia?
The GBA gene encodes an enzyme involved in brain lipid metabolism. Mutations in this gene can lead to fat accumulation and protein deposits called Lewy bodies, increasing the risk of developing Lewy Body Dementia.
What is Next-Generation Sequencing (NGS) genetic testing?
NGS is a high-throughput technology that sequences the entire GBA gene to identify mutations accurately, providing comprehensive genetic information.
How accurate is the GBA gene test for LBD susceptibility?
The test is highly accurate in detecting mutations within the GBA gene, but results should be interpreted clinically, as genetic mutations do not guarantee disease development.
What are the common symptoms of Lewy Body Dementia?
Symptoms include visual hallucinations, cognitive problems like memory loss, movement issues such as tremors, sleep disturbances, and mood changes.
How is the test performed?
The test involves collecting a blood sample or DNA extract, which is then analyzed using NGS technology in a laboratory setting.
What does a positive test result mean?
A positive result indicates the presence of GBA gene mutations associated with increased susceptibility to Lewy Body Dementia, warranting further medical consultation.
Is genetic counseling recommended before the test?
Yes, genetic counseling is advised to discuss family history, implications of testing, and to draw a pedigree chart of affected family members.
What is the cost of the GBA gene NGS test?
The test costs INR 20,000 at DNA Labs India, which includes home sample collection and report delivery.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India, as listed on our website.
How long does it take to receive the test results?
Results are typically available within 3 to 4 weeks after sample collection.
Can this test diagnose Lewy Body Dementia?
No, this test assesses genetic susceptibility but does not diagnose the disease; clinical evaluation by a neurologist is needed for diagnosis.
What should I do if I receive a positive test result?
Consult a neurologist or genetic counselor for further evaluation, monitoring strategies, and potential lifestyle or treatment options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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