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GBA Gene Parkinson disease, late-onset, susceptibility to NGS Genetic Test

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GBA Gene Parkinson disease, late-onset, susceptibility to NGS Genetic Test

Short Name: GBA NGS Test

Also known as: GBA Gene Sequencing, Glucocerebrosidase Gene NGS Test, Parkinson's Disease Genetic Susceptibility Test

GBA Gene Parkinson disease, late-onset, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger confirmation as required on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The primary purpose of this test is to detect pathogenic or likely pathogenic variants in the GBA gene that increase susceptibility to late-onset Parkinson disease. It also helps to identify at-risk relatives and supports genetic counseling.

Test Code
4443
ICD Code
G20
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS), Sanger confirmation as required
Step 1

Sample Collection

No fasting is required. Pre-test genetic counseling is recommended so that the patient understands the purpose, possible outcomes, and implications of testing.

Method: Peripheral blood draw / FTA blood spot / extracted DNA submission

Step 2

Laboratory Analysis

For blood collection, a small amount of blood is drawn from the arm. If using an FTA card, one drop of blood is applied to the card and allowed to dry.

Step 3

Report Delivery

There are no restrictions after sample collection. The FTA card should be sent in the provided envelope; blood samples should be transported under recommended conditions.

Timeline: Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:No special preparation is needed. Please share relevant family history, neurological symptoms, and previous genetic test reports with the consulting clinician.
2
During the Test:A trained phlebotomist will collect blood, or you may provide an FTA card spot or extracted DNA sample. The process is quick and minimally invasive.
3
After the Test:You may resume normal activities immediately. The sample will be transported to the laboratory under controlled conditions, and the report will be shared once completed.

About This Test

Who Should Get This Test

The primary purpose of this test is to detect pathogenic or likely pathogenic variants in the GBA gene that increase susceptibility to late-onset Parkinson disease. It also helps to identify at-risk relatives and supports genetic counseling.

How to Prepare

  • Please carry a government-issued photo ID.
  • Ensure the requisition form is completed and signed.
  • For home collection, keep the FTA card or blood sample in the provided container.
  • When using extracted DNA, ensure it is labelled with patient identifiers and accompanied by a lab requisition.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"As a clinician, I explain that GBA genetic testing is a risk-assessment tool, not a stand-alone diagnostic test. Genetic counseling before and after testing is essential for understanding results and making informed decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA vacutainer / FTA card / sterile DNA tube
Collection MethodPeripheral blood draw / FTA blood spot / extracted DNA submission

Sample Stability

Whole blood in EDTA: 2–8°C for up to 72 hours
FTA card: room temperature for several weeks
Extracted DNA: -20°C until processing
Sample Rejection Criteria:
  • Haemolysed or clotted blood sample
  • Visible mismatch between sample label and request form
  • FTA card with insufficient blood spot
  • Sample received in improper container
  • Suspected contamination or degradation

Understanding Your Results

This test provides genetic information about GBA-related Parkinson disease risk. Results must be reviewed by a clinician in the context of neurological findings and family history.
📊

Negative

No pathogenic GBA variant detected.

Recommendation: Clinical monitoring and standard Parkinson disease management based on symptoms.

📊

Positive

Pathogenic or likely pathogenic GBA variant detected.

Recommendation: Genetic counseling, neurological surveillance, and family risk assessment.

📊

Variant of Uncertain Significance (VUS)

A genetic change was found, but its effect on disease risk is not well established.

Recommendation: Further family testing may be considered; interpretation may change as evidence evolves.

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist after receiving the report to understand what the result means for you and your family. Seek urgent medical advice if new Parkinsonian symptoms such as tremor, rigidity, or difficulty with movement develop.

Limitations

  • ⚠This test does not diagnose Parkinson disease; it evaluates genetic susceptibility only.
  • ⚠Standard NGS may not detect all mutation types, including some large deletions or complex structural variants.
  • ⚠A negative result does not exclude Parkinson disease or other genetic causes.
  • ⚠Variant interpretation may change over time as new evidence emerges.
  • ⚠A positive result does not predict age of onset, disease severity, or rate of progression.

Risks & Considerations

  • ●Minor bruising or bleeding at the venepuncture site
  • ●Emotional distress or anxiety related to a genetic result
  • ●Possibility of an uncertain result or variant of uncertain significance

Interfering Factors

  • ●Recent allogeneic bone marrow transplant or blood transfusion can affect DNA results.
  • ●Insufficient or degraded DNA may affect sequencing quality.
  • ●Sample contamination or mix-up may compromise the result.
  • ●Large genomic rearrangements may not be detected by standard NGS analysis.

Compare With Similar Tests

TestGBA Gene Parkinson disease, late-onset, susceptibility to NGS Genetic Test
ComparisonGBA Gene Parkinson disease, late-onset, susceptibility to NGS Genetic Test

Frequently Asked Questions

What is the GBA gene and how is it linked to Parkinson disease?
The GBA gene provides instructions for making glucocerebrosidase. Pathogenic variants in GBA are associated with Parkinson disease, especially late-onset forms, and also with Gaucher disease when both copies are affected.
Does this NGS genetic test diagnose Parkinson disease?
No. It tests for genetic susceptibility. A positive result indicates an increased risk, not a diagnosis. Parkinson disease remains a clinical diagnosis made by a neurologist.
What sample is needed for the GBA NGS genetic test?
Blood in EDTA, extracted DNA, or one drop of blood on an FTA card can be used. DNA Labs India offers free home sample collection.
Is fasting required before the test?
No. Fasting is not required for this genetic test.
What is the cost of the GBA gene Parkinson disease NGS test in India?
At DNA Labs India the test costs Rs 20000. It includes free home sample collection in many cities across India.
How long will I receive the reports?
The report is typically available within 3 to 4 weeks after the sample reaches the laboratory.
What does a negative result mean?
A negative result means no clinically significant GBA variant was found in the regions tested. It lowers the likelihood of GBA-related Parkinson disease but does not exclude Parkinson disease or other genetic causes.
What does a positive result mean?
A pathogenic or likely pathogenic GBA variant was detected. This indicates an increased susceptibility to developing late-onset Parkinson disease. It does not guarantee that the disease will develop.
What is a variant of uncertain significance (VUS)?
A VUS is a genetic change whose effect on disease risk is not well established. If a VUS is found, additional family testing or re-analysis in future may be recommended.
Will I receive my raw data files?
Yes. DNA Labs India is transparent and provides raw data, FASTQ, and VCF files along with the clinical report.
Should I have genetic counseling before taking this test?
Yes. A genetic counseling session is recommended to draw a pedigree and to explain the benefits, limitations, and possible implications before and after testing.
Can GBA mutations cause Parkinson disease in children?
Parkinson disease associated with GBA variants is typically late-onset and occurs in adults. Childhood-onset Parkinsonism due to GBA is extremely rare and not the focus of this susceptibility test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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