GREM1 Gene Polyposis syndrome, hereditary mixed NGS Genetic Test
Short Name: GREM1 NGS Genetic Test
Also known as: HMPS Genetic Test, GREM1 Mutation Analysis, Hereditary Mixed Polyposis Syndrome NGS Panel
GREM1 Gene Polyposis syndrome, hereditary mixed NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect pathogenic variants in the GREM1 gene that are associated with hereditary mixed polyposis syndrome. This test aids in confirming a clinical diagnosis, identifying asymptomatic carriers in affected families, and guiding personalized management plans to reduce colorectal cancer risk. It is also useful for reproductive planning and genetic counseling.
- Test Code
- 6014
- CPT Code
- 81435
- ICD Code
- Z15.09
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before the test to discuss the implications and obtain informed consent.
Method: Venipuncture or Fingerstick
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. If using FTA card, a fingerstick blood drop will be applied to the card.
Report Delivery
No specific precautions are needed. You can resume normal activities immediately.
Timeline: Reports are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect pathogenic variants in the GREM1 gene that are associated with hereditary mixed polyposis syndrome. This test aids in confirming a clinical diagnosis, identifying asymptomatic carriers in affected families, and guiding personalized management plans to reduce colorectal cancer risk. It is also useful for reproductive planning and genetic counseling.
How to Prepare
- For blood sample: Use EDTA vacutainer, fill to the indicated mark.
- For FTA card: Apply one drop of blood onto the designated circle and allow to air dry.
- Label the sample with patient name, date, and time of collection.
- Transport the sample to the laboratory at ambient temperature (15-30°C).
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for GREM1 mutations is crucial for early detection and management of hereditary mixed polyposis syndrome, significantly reducing colorectal cancer risk through surveillance and prophylactic interventions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improperly labeled sample
- Sample received after prolonged transit time (>72 hours) without proper storage
Understanding Your Results
Pathogenic variant detected
Confirms the diagnosis of GREM1 gene polyposis syndrome. Increased risk of colorectal polyps and cancer. Recommend regular colonoscopy surveillance and consider prophylactic colectomy in severe cases.
Likely pathogenic variant detected
Likely disease-causing; similar management as pathogenic variant. Further family studies may be helpful.
Variant of uncertain significance (VUS)
The clinical significance is unknown. Additional testing of family members and functional studies may be needed.
No pathogenic variant detected
No mutation found in GREM1 gene. However, a genetic cause cannot be completely excluded; consider testing other genes if clinical suspicion remains high.
If you have a family history of GREM1 polyposis syndrome, multiple polyps, or early-onset colorectal cancer, consult your doctor or a genetic counselor to discuss the appropriateness of this test and to interpret the results.
Limitations
- ⚠This test detects variants in the GREM1 gene only; other genes associated with polyposis syndromes are not covered.
- ⚠Variant of uncertain significance (VUS) may be reported; further family studies may be required.
- ⚠This test does not assess the methylation status or other epigenetic changes.
- ⚠Negative result does not rule out the possibility of a genetic cause due to undetected variants or other genes.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of receiving a positive or uncertain result
- ●Potential for genetic discrimination (though laws like GINA protect in some regions)
Interfering Factors
- ●Contamination of sample with foreign DNA
- ●Insufficient DNA quantity or quality
- ●Recent blood transfusion (within 2 weeks) may dilute nucleated cells
- ●Bone marrow transplantation can affect results
Compare With Similar Tests
| Test | GREM1 Gene Polyposis syndrome, hereditary mixed NGS Genetic Test | APC Gene Sequencing | MUTYH Gene Sequencing | PTEN Gene Sequencing | SMAD4 Gene Sequencing |
|---|---|---|---|---|---|
| Comparison | GREM1 Gene Polyposis syndrome, hereditary mixed NGS Genetic Test |
Frequently Asked Questions
What is GREM1 gene polyposis syndrome?
How is the GREM1 NGS genetic test performed?
What is the cost of the GREM1 gene polyposis NGS test in India?
Do I need to fast before the test?
How long does it take to get the results?
What is the sample type required?
Will I receive raw data files?
Is genetic counseling included?
Can this test be done for family members?
What does a negative result mean?
Is home sample collection available?
What is the turnaround time for reports?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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