GRID2 Gene Schizophrenia, GRID2 related NGS Genetic Test
Short Name: GRID2 Schizophrenia NGS Test
Also known as: GRID2 Gene Test, GRID2 Schizophrenia Genetic Panel, Glutamate Receptor Delta-2 Gene Test, GRID2 NGS Panel, Schizophrenia Genetic Risk Test
GRID2 Gene Schizophrenia, GRID2 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger Confirmation, Bioinformatic Analysis on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are accessible through the online patient portal and are also shared via email and WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the GRID2 Gene Schizophrenia NGS Genetic Test is to identify pathogenic or likely pathogenic genetic variants in the GRID2 gene that may increase an individual's susceptibility to schizophrenia. This test supports clinical risk assessment, genetic counselling, family planning decisions, and personalised treatment approaches. It is not a diagnostic test for schizophrenia but serves as a supplementary tool in the comprehensive evaluation of patients with psychotic spectrum disorders or a family history of schizophrenia.
- Test Code
- 1808
- CPT Code
- 81479
- ICD Code
- F20.9
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are accessible through the online patient portal and are also shared via email and WhatsApp.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger Confirmation, Bioinformatic Analysis
Sample Collection
No special preparation or fasting is required. Provide complete clinical history and family pedigree information to the genetic counsellor prior to sample collection.
Method: Venipuncture / Finger Prick (FTA Card)
Laboratory Analysis
A trained phlebotomist will collect 3-5 mL of venous blood in an EDTA tube, or a single drop of blood may be applied to an FTA card. The procedure typically takes less than 5 minutes.
Report Delivery
Apply light pressure to the puncture site with cotton for 2-3 minutes. There are no activity restrictions after blood collection. Reports will be available within 3 to 4 weeks.
Timeline: Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are accessible through the online patient portal and are also shared via email and WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the GRID2 Gene Schizophrenia NGS Genetic Test is to identify pathogenic or likely pathogenic genetic variants in the GRID2 gene that may increase an individual's susceptibility to schizophrenia. This test supports clinical risk assessment, genetic counselling, family planning decisions, and personalised treatment approaches. It is not a diagnostic test for schizophrenia but serves as a supplementary tool in the comprehensive evaluation of patients with psychotic spectrum disorders or a family history of schizophrenia.
How to Prepare
- Ensure the patient has not received a blood transfusion in the past 4 weeks
- Use an EDTA (lavender top) vacutainer for whole blood collection
- If using an FTA card, ensure the blood drop fully saturates the designated area
- Label the sample clearly with patient name, date of birth, and sample ID
- Store the sample at ambient room temperature and transport to the lab within 48 hours
- Complete the requisition form with clinical history and genetic counselling details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for schizophrenia-associated genes such as GRID2 can provide valuable information for patients with a strong family history of psychotic disorders. While a positive genetic finding does not confirm a diagnosis of schizophrenia, it can guide risk assessment, early intervention strategies, and personalised treatment planning. I recommend this test in conjunction with comprehensive clinical evaluation and genetic counselling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed or clotted blood sample
- Sample collected in incorrect anticoagulant tube (non-EDTA)
- Insufficient sample volume
- Sample without proper labelling or requisition form
- Contaminated FTA card sample
- Sample older than stability limits at time of receipt
Understanding Your Results
Pathogenic Variant Detected
A known disease-causing variant in the GRID2 gene was identified. This may indicate increased genetic susceptibility to schizophrenia. Clinical correlation and genetic counselling are strongly recommended.
Likely Pathogenic Variant Detected
A variant with strong evidence suggesting disease association was identified. Further clinical evaluation and family segregation analysis may be warranted.
Variant of Uncertain Significance (VUS)
A variant was detected but current evidence is insufficient to determine its clinical significance. Periodic reclassification may be necessary as new data become available.
Likely Benign Variant Detected
A variant was detected but is unlikely to be associated with schizophrenia risk. No clinical action is typically indicated.
No Pathogenic Variant Detected
No clinically significant variants were identified in the GRID2 gene. This does not rule out genetic risk for schizophrenia from other genetic or environmental factors.
Consult a psychiatrist or clinical geneticist if the test reveals a pathogenic or likely pathogenic variant in the GRID2 gene, if a variant of uncertain significance is detected, if there is a strong family history of schizophrenia or psychotic disorders, or if you or your family member is experiencing symptoms such as hallucinations, delusions, disorganised thinking, or social withdrawal. Early professional evaluation can help guide appropriate management and intervention strategies.
Limitations
- ⚠This test analyses only the GRID2 gene and does not cover all genes implicated in schizophrenia
- ⚠Schizophrenia is a polygenic disorder; a negative result does not eliminate genetic risk
- ⚠Variants of uncertain significance (VUS) may be detected and cannot be used for clinical decision-making without further evidence
- ⚠Structural variants, large deletions/duplications, and repeat expansions may not be fully detected by this NGS panel
- ⚠Results should be interpreted in conjunction with clinical assessment and family history by a qualified professional
Risks & Considerations
- ●Blood collection may cause minor bruising or discomfort at the puncture site
- ●Psychological distress upon receiving results indicating genetic predisposition
- ●Potential for insurance or employment discrimination based on genetic information (addressed under India's Genetic Data Privacy guidelines)
- ●Risk of misinterpretation of results without professional genetic counselling
Interfering Factors
- ●Degraded or insufficient DNA quality may affect sequencing accuracy
- ●Recent blood transfusion within 4 weeks may affect sample purity
- ●Contamination during sample collection or transport
- ●Use of anticoagulants other than EDTA may interfere with DNA extraction
Compare With Similar Tests
| Test | GRID2 Gene Schizophrenia, GRID2 related NGS Genetic Test | Whole Exome Sequencing (WES) | Schizophrenia Multi-Gene Panel | Chromosomal Microarray Analysis (CMA) |
|---|---|---|---|---|
| Comparison | GRID2 Gene Schizophrenia, GRID2 related NGS Genetic Test |
Frequently Asked Questions
What is the GRID2 gene and how is it related to schizophrenia?
Who should consider getting the GRID2 Gene Schizophrenia NGS Genetic Test?
What sample is required for this genetic test?
How long does it take to receive the results?
Does a positive result mean I definitely have schizophrenia?
What does it mean if the test finds a Variant of Uncertain Significance (VUS)?
Is home sample collection available for this test?
What is the cost of the GRID2 Gene Schizophrenia NGS Genetic Test in India?
Is genetic testing for schizophrenia covered by insurance in India?
What files and reports does DNA Labs India provide with this test?
Can this test be used for prenatal or preconception genetic counselling?
What should I do after receiving my test results?
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