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GRID2 Gene Spinocerebellar ataxia type 18, autosomal recessive NGS Genetic Test

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GRID2 Gene Spinocerebellar ataxia type 18, autosomal recessive NGS Genetic Test

Short Name: SCA18 NGS Genetic Test

Also known as: Spinocerebellar ataxia type 18, SCA18

GRID2 Gene Spinocerebellar ataxia type 18, autosomal recessive NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the GRID2 gene that cause spinocerebellar ataxia type 18 (SCA18), aiding in diagnosis, carrier testing, and genetic counseling for affected individuals and families.

Test Code
4571
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and genetic counseling information.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist. For FTA card, a drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site. Sample will be processed and sent to the lab.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide detailed clinical history and undergo genetic counseling.
2
During the Test:Sample collection as per instructions.
3
After the Test:Wait for results and follow up with genetic counseling.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the GRID2 gene that cause spinocerebellar ataxia type 18 (SCA18), aiding in diagnosis, carrier testing, and genetic counseling for affected individuals and families.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment
  • Label samples correctly
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for SCA18 is crucial for accurate diagnosis, enabling personalized management and informed family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the GRID2 gene. A positive result confirms SCA18, while a negative result may require further testing or clinical correlation.
Consult a geneticist for result interpretation
Consider family history and clinical symptoms
Genetic counseling recommended for all cases
⚠️ When to Consult a Doctor:

If you experience symptoms of ataxia, have a family history of SCA18, or receive a positive test result, consult a neurologist or geneticist immediately.

Limitations

  • ⚠May not detect all types of mutations (e.g., large deletions)
  • ⚠Requires interpretation by a geneticist
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal physical risk from blood draw
  • ●Psychological impact of results
  • ●Privacy and confidentiality concerns

Interfering Factors

  • ●Degraded DNA samples
  • ●Contamination during sample handling
  • ●Technical errors in sequencing

Frequently Asked Questions

What is Spinocerebellar ataxia type 18 (SCA18)?
SCA18 is a rare genetic disorder caused by mutations in the GRID2 gene, leading to progressive cerebellar ataxia affecting coordination and movement.
What are the symptoms of SCA18?
Symptoms include loss of coordination, balance problems, tremors, slurred speech, difficulty with fine motor skills, and sometimes vision or cognitive issues.
How is SCA18 diagnosed?
Diagnosis involves clinical evaluation, genetic testing using next-generation sequencing (NGS) to identify GRID2 gene mutations, and imaging studies like MRI.
What does the NGS genetic test for SCA18 involve?
The test analyzes the entire coding region of the GRID2 gene using NGS technology to detect pathogenic mutations associated with SCA18.
What is the cost of the SCA18 genetic test at DNA Labs India?
The test costs INR 20,000, which includes sample collection, analysis, genetic counseling, and report delivery.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available for this test?
Yes, free home sample collection is available across India for online bookings, covering numerous cities.
What sample is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Do I need to fast before the test?
No, fasting is not required for this genetic test.
How accurate is the NGS genetic test for SCA18?
NGS is highly accurate for detecting mutations in the GRID2 gene, but results should be interpreted by a qualified geneticist in the context of clinical findings.
Can this test be used for carrier testing?
Yes, the test can identify carriers of SCA18 mutations, which is useful for family planning and genetic counseling.
What should I do if the test result is positive?
If positive, consult a neurologist or geneticist for further management, genetic counseling, and to discuss implications for family members.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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