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GRIN1 Gene Mental retardation, autosomal dominant type 8 NGS Genetic Test

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GRIN1 Gene Mental retardation, autosomal dominant type 8 NGS Genetic Test

Short Name: GRIN1 NGS Test

Also known as: GRIN1 gene testing, GRIN1-related intellectual disability genetic test, Autosomal dominant type 8 mental retardation NGS test

GRIN1 Gene Mental retardation, autosomal dominant type 8 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks after sample collection.. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To detect disease-causing variants in the GRIN1 gene by Next-Generation Sequencing in individuals with suspected autosomal dominant type 8 mental retardation / intellectual disability.

Test Code
4251
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are generally available within 3 to 4 weeks after sample collection.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. A genetic counselling session to draw a pedigree chart of family members affected with GRIN1-related intellectual disability is recommended before the test.

Method: Venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

A simple blood sample is collected by a trained phlebotomist, or a blood spot is placed on an FTA card for one-drop collection. If extracted DNA is provided, the sample is directly used for analysis.

Step 3

Report Delivery

No special precautions are needed after sample collection. You may resume normal activities.

Timeline: Reports are generally available within 3 to 4 weeks after sample collection.

Patient Instructions

1
Before the Test:No special preparation is needed. A pre-test genetic counselling session is recommended to draw a family pedigree and discuss the implications of genetic testing.
2
During the Test:The sample is collected as blood or a blood spot on an FTA card. After reaching the laboratory, DNA is extracted and the GRIN1 gene is analysed using NGS technology.
3
After the Test:You will receive the clinical report in 3 to 4 weeks. A post-test genetic counselling session is recommended to explain the results and discuss further management.

About This Test

Who Should Get This Test

To detect disease-causing variants in the GRIN1 gene by Next-Generation Sequencing in individuals with suspected autosomal dominant type 8 mental retardation / intellectual disability.

How to Prepare

  • No fasting required
  • Informed consent should be obtained before genetic testing
  • A referral from a neurologist, paediatrician or clinical geneticist is recommended
  • For FTA card, ensure the blood spot is dried and stored as per instructions
  • Clearly label the sample with the patient's name and unique ID

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for GRIN1-associated intellectual disability can provide a molecular basis for the condition and support informed decisions about management and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory requirement
ContainerEDTA tube / FTA card / Extracted DNA vial
Collection MethodVenipuncture or FTA card blood spot

Sample Stability

Whole blood: Transport to the laboratory within 24-48 hours at room temperature
FTA card: Stable for several weeks at room temperature when stored dry
Extracted DNA: Stable at 2-8°C for short-term transport
Sample Rejection Criteria:
  • Mislabeled or unlabeled sample
  • Frozen whole blood
  • Insufficient sample volume
  • Contaminated sample
  • Missing consent form or clinical details

Understanding Your Results

The clinical report provides a molecular interpretation of variants detected in the GRIN1 gene. Variants are classified according to international guidelines and correlated with the patient's clinical history.
📊

Consistent with a molecular diagnosis of GRIN1-associated autosomal dominant type 8 mental retardation.

📊

No evidence of GRIN1-related intellectual disability; other genetic and non-genetic causes should be considered.

📊

Insufficient evidence to assign a clear pathogenic or benign role; additional family studies and clinical correlation may be helpful.

📊

Not considered to be the cause of the patient's intellectual disability.

⚠️ When to Consult a Doctor:

Consult a clinical geneticist, neurologist or paediatrician if you or your child has unexplained intellectual disability, developmental delay, seizures, behavioural abnormalities, or a family history of GRIN1-related conditions and need recurrence-risk counselling.

Limitations

  • ⚠NGS may not detect all types of mutations such as large structural rearrangements or deep intronic variants unless specifically assayed
  • ⚠Negative result does not exclude all genetic causes of intellectual disability
  • ⚠Variant of uncertain significance requires further clinical and family correlation
  • ⚠This test is not intended for prenatal diagnosis unless specifically validated and requested

Risks & Considerations

  • ●Minimal risk of bleeding from venipuncture
  • ●Slight bruising at the needle site
  • ●Dizziness or faintness during blood draw

Interfering Factors

  • ●History of allogeneic bone marrow transplantation
  • ●Recent blood transfusion
  • ●Sample contamination or inadequate DNA quantity
  • ●Incomplete coverage in some genomic regions
  • ●Consanguineous family backgrounds may require additional analysis

Compare With Similar Tests

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ComparisonGRIN1 Gene Mental retardation, autosomal dominant type 8 NGS Genetic Test

Frequently Asked Questions

What sample is required for the GRIN1 gene NGS genetic test?
The test can be performed on blood, extracted DNA, or one drop of blood on an FTA card. The sample type is confirmed at the time of booking.
Does the GRIN1 gene test require fasting?
No, fasting is not required for this genetic test.
How long will it take to receive my report?
The turnaround time for the GRIN1 gene mental retardation type 8 NGS genetic test is 3 to 4 weeks.
What does a pathogenic or likely pathogenic result mean?
It means a disease-causing variant was identified in the GRIN1 gene, which is consistent with a molecular diagnosis of autosomal dominant type 8 mental retardation.
Can a negative result rule out intellectual disability?
A negative result means no pathogenic GRIN1 variant was detected, but it does not exclude all genetic causes of intellectual disability. Further testing may be recommended.
Is genetic counselling necessary before the test?
Yes, pre-test genetic counselling is recommended to discuss the benefits, limitations, and implications of testing, and to draw a family pedigree.
Does DNA Labs India provide raw data, FASTQ, and VCF files?
Yes, DNA Labs India is transparent and provides raw data, FASTQ, and VCF files along with the conclusive clinical report.
What is the cost of the GRIN1 gene NGS genetic test in India?
The cost is INR 20000, which includes free home sample collection across many cities in India.
Which cities have free home sample collection for this test?
Free home sample collection is available in major cities including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune, and many other locations across India.
Who should take this test?
This test is recommended for individuals with unexplained intellectual disability, developmental delay, learning difficulties, behavioural problems, or a family history of GRIN1-related autosomal dominant type 8 mental retardation.
Is the GRIN1 gene test covered by medical insurance?
Coverage varies by insurance provider. It is advisable to check with your insurance company or with the lab support team for pre-authorization and reimbursement.
What is autosomal dominant type 8 mental retardation?
It is a form of intellectual disability caused by pathogenic variants in the GRIN1 gene. The condition follows an autosomal dominant inheritance pattern and can affect cognitive function, motor skills, behaviour, and development.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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