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GRIN2B Gene Mental retardation, autosomal dominant type 6 NGS Genetic Test

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GRIN2B Gene Mental retardation, autosomal dominant type 6 NGS Genetic Test

Short Name: GRIN2B NGS Genetic Test

Also known as: GRIN2B-related intellectual disability, Mental retardation autosomal dominant type 6, MRD6

GRIN2B Gene Mental retardation, autosomal dominant type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are dispatched within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the GRIN2B gene associated with Autosomal Dominant Mental Retardation Type 6 (MRD6). This test aids in confirming a clinical diagnosis, assessing recurrence risk, and guiding genetic counseling.

Test Code
4249
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are dispatched within 3 to 4 weeks after sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting required. Clinical history and genetic counseling session required. A pedigree chart of family members affected with GRIN2B gene mental retardation should be drawn during genetic counseling.

Method: Blood Draw or FTA Card Spot

Step 2

Laboratory Analysis

Blood sample is collected by routine venipuncture or a few drops of blood are placed on the FTA card.

Step 3

Report Delivery

No specific aftercare required.

Timeline: Reports are dispatched within 3 to 4 weeks after sample receipt.

Patient Instructions

1
Before the Test:No fasting required. Clinical history and genetic counseling session required. A pedigree chart of family members affected with GRIN2B gene mental retardation should be drawn during genetic counseling.
2
During the Test:Blood sample is collected by routine venipuncture or a few drops of blood are placed on the FTA card.
3
After the Test:No specific aftercare required.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect pathogenic or likely pathogenic variants in the GRIN2B gene associated with Autosomal Dominant Mental Retardation Type 6 (MRD6). This test aids in confirming a clinical diagnosis, assessing recurrence risk, and guiding genetic counseling.

How to Prepare

  • Use the provided EDTA blood collection tube or FTA card
  • Label the sample with patient name and unique ID
  • Maintain sample at ambient room temperature for transport

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic counseling is recommended before and after testing to understand the implications of results."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeNot Specified
ContainerEDTA tube or FTA card
Collection MethodBlood Draw or FTA Card Spot
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Incorrect label or missing patient identifier
  • Sample received beyond stability period

Understanding Your Results

The result report is prepared by a molecular geneticist and will be accompanied by an interpretive summary.
If a pathogenic or likely pathogenic variant is found, the result is positive and supports the clinical diagnosis of GRIN2B-related disorder.
If no pathogenic variant is found, it does not exclude a genetic cause; other genes may be involved.
A variant of uncertain significance (VUS) may be reported; further testing or family studies may be recommended.
⚠️ When to Consult a Doctor:

Consult a geneticist or neurologist if any variant of uncertain significance is detected or if you have a family history of intellectual disability.

Limitations

  • ⚠NGS may not detect all types of mutations such as large structural rearrangements
  • ⚠Variant of uncertain significance may be reported
  • ⚠Low-level mosaicism may be missed
  • ⚠This test does not assess other genes associated with intellectual disability

Risks & Considerations

  • ●Minimal bleeding, bruising, or infection at the blood draw site

Interfering Factors

  • ●Presence of homologous pseudogenes may affect variant calling
  • ●DNA quality and quantity may impact sequencing performance
  • ●Low-level mosaicism may not be detected

Frequently Asked Questions

What is the cost of the GRIN2B NGS genetic test at DNA Labs India?
The cost is INR 20,000 (Rs 20,000), and free home sample collection is included for online bookings.
What sample type is required for this test?
The test can be performed on blood, extracted DNA, or one drop of blood on an FTA card.
How long does the GRIN2B NGS test take?
Reports are typically delivered in 3 to 4 weeks after sample receipt.
Is fasting required for the GRIN2B NGS test?
No, fasting is not required for this genetic test.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection in many cities across India for this test.
What is GRIN2B-related mental retardation?
It is an autosomal dominant genetic disorder caused by mutations in the GRIN2B gene, leading to intellectual disability and developmental delays.
Who should undergo this GRIN2B gene test?
Individuals with intellectual disability, speech delay, seizures, behavioral problems, or a family history of GRIN2B-related conditions may be recommended for this test.
How is the GRIN2B NGS test performed?
The test uses Next-Generation Sequencing (NGS) technology to analyse the coding regions and splice sites of the GRIN2B gene.
What does a negative result mean?
A negative result suggests no pathogenic variant was found in the GRIN2B gene, but it does not exclude other genetic causes of intellectual disability.
What are the common symptoms of GRIN2B-related disorder?
Common symptoms include intellectual disability, delayed speech and language development, behavioral problems, seizures, sleep disturbances, and muscle tone abnormalities.
Is genetic counseling required before this test?
Yes, a genetic counseling session to draw a pedigree chart of family members is part of the pre-test process.
What is the CPT code for this test?
The CPT code is not publicly listed; please contact DNA Labs India directly for billing-related coding information.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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