GRN Gene Dementia, frontotemporal NGS Genetic Test
Short Name: GRN FTD NGS Test
Also known as: GRN Gene Mutation Test, Progranulin Gene Sequencing, Frontotemporal Dementia Genetic Panel, GRN NGS Analysis
GRN Gene Dementia, frontotemporal NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The test reports will be delivered within 3 to 4 weeks from the date of sample receipt. Reports are uploaded to the patient portal and shared via email/WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the GRN gene frontotemporal NGS genetic test is to identify pathogenic variants in the GRN gene that are associated with frontotemporal dementia. It aids in confirming a clinical diagnosis, differentiating FTD from other dementia subtypes, providing information about disease prognosis, and enabling predictive testing for at-risk family members. The test also supports clinicians in making informed management decisions and in counseling families regarding recurrence risk.
- Test Code
- 3997
- CPT Code
- 81413
- ICD Code
- G31.09
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The test reports will be delivered within 3 to 4 weeks from the date of sample receipt. Reports are uploaded to the patient portal and shared via email/WhatsApp.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. Please carry a valid government ID and any previous medical reports or imaging scans. It is recommended to complete the genetic counseling session before sample collection.
Method: Peripheral Venipuncture / FTA Card Blood Spot
Laboratory Analysis
The sample will be collected by a trained phlebotomist using sterile methods. If using an FTA card, a few drops of capillary blood will be spotted onto the card. The procedure is quick and virtually painless.
Report Delivery
You may resume all normal activities immediately after sample collection. No special precautions are required. The sample will be transported to our laboratory under temperature-controlled conditions.
Timeline: The test reports will be delivered within 3 to 4 weeks from the date of sample receipt. Reports are uploaded to the patient portal and shared via email/WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the GRN gene frontotemporal NGS genetic test is to identify pathogenic variants in the GRN gene that are associated with frontotemporal dementia. It aids in confirming a clinical diagnosis, differentiating FTD from other dementia subtypes, providing information about disease prognosis, and enabling predictive testing for at-risk family members. The test also supports clinicians in making informed management decisions and in counseling families regarding recurrence risk.
How to Prepare
- Please inform us if you have had a bone marrow transplant or blood transfusion in the past 6 months.
- For home collection, ensure an adult is present at the time of collection.
- If you have received blood products recently, consider postponing genetic testing to avoid DNA contamination.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic counseling before testing is essential to assess inheritance patterns and discuss implications for family members."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed or clotted blood samples
- Samples received without proper labeling or consent
- Samples shipped at room temperature for more than 7 days
- Inadequate DNA quantity or quality for NGS
Understanding Your Results
Pathogenic variant detected
The variant is disease-causing and confirms the genetic basis of frontotemporal dementia. Predictive testing of at-risk relatives is indicated with genetic counseling.
Likely pathogenic variant detected
The variant is likely to cause disease. Confirmatory testing or additional evidence may be required. Clinical correlation is essential.
Variant of uncertain significance (VUS)
The significance of the variant is unknown. Further segregation analysis, functional studies, and consultation with a geneticist are recommended.
No pathogenic variant detected
No disease-causing mutation was identified in the GRN gene. This does not exclude other genetic causes of FTD. Consider broader testing if clinical suspicion is high.
If you or a family member experience early-onset behavioral changes, language difficulties, or memory problems suggestive of frontotemporal dementia, you should consult a neurologist. If a hereditary cause is suspected, ask for a referral to a genetic specialist or memory disorders clinic.
Limitations
- ⚠This test detects mutations in the GRN gene only and does not rule out other genes involved in frontotemporal dementia such as MAPT, C9orf72, TARDBP, or FUS.
- ⚠The test does not measure progranulin protein levels; a functional assay may be recommended separately.
- ⚠Some non-coding or deep intronic variants may not be detected by standard NGS.
- ⚠Large deletions or duplications in the GRN gene may require additional MLPA analysis.
- ⚠Variant classification may change as new research emerges.
- ⚠Predictive testing in asymptomatic individuals requires pre- and post-test genetic counseling and should not be performed in minors unless clinically indicated.
Risks & Considerations
- ●Genetic testing may reveal unexpected information about family relationships.
- ●Psychological distress after learning a positive or inconclusive result.
- ●Potential discrimination by insurers or employers if disclosed; however, the Genetic Information Non-Discrimination Act provides some protections in India.
- ●Predictive test results may affect insurability and family dynamics.
Interfering Factors
- ●Poor quality or degraded DNA sample
- ●Contaminated blood samples or non-sterile collection
- ●Incomplete clinical information or pedigree
- ●Chimeric or bone marrow transplantation history
- ●Rare technical artifacts in NGS requiring confirmatory Sanger sequencing
Compare With Similar Tests
| Test | GRN Gene Dementia, frontotemporal NGS Genetic Test | ||
|---|---|---|---|
| Comparison | GRN Gene Dementia, frontotemporal NGS Genetic Test |
Frequently Asked Questions
What is the GRN gene and how is it related to frontotemporal dementia?
What is the cost of the GRN gene frontotemporal NGS genetic test in India?
What sample is needed for this test?
Do I need to fast before giving a sample?
How long will it take to get the test results?
Will I get the raw data files (FASTQ and VCF)?
Is genetic counseling required before the test?
Can this test detect all mutations in all genes associated with FTD?
What does a negative GRN test result mean?
Can the test be done on a presymptomatic person with a family history?
Is this test covered by insurance?
What is the difference between GRN gene testing and C9orf72 testing?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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