GSN Gene Amyloidosis, Finnish Type NGS Genetic Test
Short Name: GSN NGS Genetic Test
Also known as: Finnish Type Amyloidosis, Hereditary Gelsolin Amyloidosis, AGel Amyloidosis, Gelsolin-Related Amyloidosis
GSN Gene Amyloidosis, Finnish Type NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are available within 3 to 4 weeks after the laboratory receives the sample.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify clinically significant sequence variants in the GSN gene. It is used to confirm a diagnosis of Finnish type amyloidosis, support carrier and family testing, guide predictive testing in at-risk relatives, and assist in reproductive and medical management planning.
- Test Code
- 3877
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are available within 3 to 4 weeks after the laboratory receives the sample.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counselling session to prepare a family pedigree and obtain informed consent is recommended before the test.
Method: Peripheral venipuncture / FTA card blood spot
Laboratory Analysis
Blood sample will be collected by a trained phlebotomist using appropriate blood collection tubes; alternatively, a single blood spot may be collected on an FTA card.
Report Delivery
The sample will be sent to the laboratory for analysis. No special restrictions are needed after collection. You may resume normal activities immediately.
Timeline: Reports are available within 3 to 4 weeks after the laboratory receives the sample.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify clinically significant sequence variants in the GSN gene. It is used to confirm a diagnosis of Finnish type amyloidosis, support carrier and family testing, guide predictive testing in at-risk relatives, and assist in reproductive and medical management planning.
How to Prepare
- Inform the referring physician about any prior history of amyloidosis or genetic testing.
- No fasting is required for this test.
- For blood sample, use an EDTA tube and mix gently by inverting the tube.
- For FTA card, apply one drop of blood to the printed circle and allow it to air dry completely.
- Label the sample clearly with the patient's full name, date of birth, and date of collection.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"When Finnish type amyloidosis is suspected or confirmed, a detailed family history and referral for genetic counselling can clarify the recurrence risk and guide reproductive and preconception planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed or clotted EDTA blood sample
- Frozen whole blood
- Insufficient DNA quantity or quality
- Unlabelled or incorrectly labelled sample
- Wet or expired FTA card
Understanding Your Results
Pathogenic variant detected
Confirms the molecular diagnosis of GSN gene amyloidosis in an appropriate clinical context.
Recommendation: Refer to clinical genetics for detailed management, family screening, and reproductive counselling.
Likely pathogenic variant detected
Highly suggestive of GSN gene amyloidosis; additional clinical or family evidence may be needed.
Recommendation: Segregation testing in family members and detailed clinical correlation are recommended.
Variant of uncertain significance (VUS) detected
Cannot be used to confirm or exclude disease at this time.
Recommendation: Further family studies and genetic counselling are advised to help reclassify the variant.
No pathogenic variant detected
Does not exclude hereditary or acquired amyloidosis; clinical diagnosis remains important.
Recommendation: Consider broader amyloidosis gene panel, clinical evaluation, or specialist review.
Benign / likely benign variant detected
No clinical significance for the patient's phenotype.
Recommendation: No additional action based on this finding; continue clinical management as indicated.
Consult a clinical geneticist if a pathogenic or likely pathogenic variant is detected, if a variant of uncertain significance is found, or if you have a family history of hereditary amyloidosis and are considering predictive testing.
Limitations
- ⚠This targeted NGS test only analyses the GSN gene; it does not rule out other forms of hereditary or acquired amyloidosis.
- ⚠Large structural rearrangements, deep intronic variants, promoter variants, or repeat expansions may not be detected by this NGS approach.
- ⚠A finding of no pathogenic variant does not exclude a clinical diagnosis of amyloidosis.
- ⚠Variants of uncertain significance require additional family studies and genetic counselling.
Risks & Considerations
- ●Mild pain or bruising at the venipuncture site
- ●Rare infection or bleeding following blood collection
- ●Psychological impact of genetic findings
- ●Uncertainty from variants of uncertain significance
Interfering Factors
- ●DNA degradation due to improper sample storage or transport
- ●PCR inhibition from contaminants in the blood sample
- ●Cross-contamination during sample handling
- ●Variants outside the targeted GSN gene regions are not evaluated
Compare With Similar Tests
| Test | GSN Gene Amyloidosis, Finnish Type NGS Genetic Test | Sanger Sequencing for Known Familial Variant | Whole Exome Sequencing |
|---|---|---|---|
| Comparison | GSN Gene Amyloidosis, Finnish Type NGS Genetic Test |
Frequently Asked Questions
What is GSN Gene Amyloidosis, Finnish Type?
What is the cost of GSN Gene Amyloidosis NGS Genetic Test at DNA Labs India?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get reports?
What does the NGS test detect?
Will I receive raw data files?
Can this test be used in asymptomatic family members?
What do negative results mean?
What is a Variant of Uncertain Significance (VUS)?
Who should order this test?
Is home sample collection available across India?
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