HAM Test Paroxysmal Nocturnal Hemoglobinuria (PNH) Screening Test
Short Name: HAM Test PNH
Also known as: Ham Test, PNH Screening Test
HAM Test Paroxysmal Nocturnal Hemoglobinuria (PNH) Screening Test test available at DNA Labs India for ₹1,404. Uses Gel Technique on Whole Blood samples. Results in Same-day reports available if sample is received by 9 am; typically within 24 hours otherwise.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the HAM Test is to screen for Paroxysmal Nocturnal Hemoglobinuria by detecting abnormal red blood cells that are sensitive to complement-mediated lysis under acidic conditions, aiding in early identification and management of this rare disorder.
- Test Code
- 685
- Price
- ₹1,404
- Sample Type
- Whole Blood
- Result Time
- Same-day reports available if sample is received by 9 am; typically within 24 hours otherwise.
- Fasting Required
- No
- Method
- Gel Technique
Sample Collection
No special preparation required. Inform your doctor about any medications or recent transfusions.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Resume normal activities unless advised otherwise.
Timeline: Same-day reports available if sample is received by 9 am; typically within 24 hours otherwise.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the HAM Test is to screen for Paroxysmal Nocturnal Hemoglobinuria by detecting abnormal red blood cells that are sensitive to complement-mediated lysis under acidic conditions, aiding in early identification and management of this rare disorder.
How to Prepare
- Collect 3 mL of whole blood in a Lavender Top (EDTA) tube.
- Mix gently to prevent clotting.
- Ship refrigerated; do not freeze.
- Ensure sample is labeled correctly with patient details.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The Ham test is a valuable initial screening tool for PNH, aiding in early detection and guiding further confirmatory tests like flow cytometry for optimal patient management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed, clotted, or insufficient sample volume.
- Incorrect tube type or improper labeling.
- Sample not shipped refrigerated or frozen.
Understanding Your Results
Negative
No significant lysis observed; PNH is less likely, but clinical correlation is needed.
Positive
Lysis detected, indicating possible PNH cells. Confirmatory testing with flow cytometry is recommended.
Consult a hematologist if you have symptoms like chronic anemia, dark urine, or unexplained fatigue, or if the Ham test result is positive for further evaluation and management.
Limitations
- ⚠The Ham test is a screening test and not confirmatory; positive results require verification with flow cytometry.
- ⚠It may yield false negatives in early PNH or with small clone sizes.
- ⚠Does not quantify the PNH clone size.
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site.
- ●Rare risk of infection or excessive bleeding.
Interfering Factors
- ●Hemolyzed or improperly stored samples
- ●Recent blood transfusions may affect results
- ●Use of certain medications that influence complement activity
Compare With Similar Tests
| Test | HAM Test Paroxysmal Nocturnal Hemoglobinuria (PNH) Screening Test | Flow Cytometry for PNH | Bone Marrow Biopsy | FLAER-based Flow Cytometry |
|---|---|---|---|---|
| Comparison | HAM Test Paroxysmal Nocturnal Hemoglobinuria (PNH) Screening Test |
Frequently Asked Questions
What is the Ham test for PNH?
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What is the cost of the Ham test at DNA Labs India?
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