HCN2 Gene Epilepsy, HCN2 related NGS Genetic Test
Short Name: HCN2 Gene Epilepsy NGS
Also known as: HCN2 epilepsy genetic test, HCN2 mutation analysis, HCN2 NGS sequencing test
HCN2 Gene Epilepsy, HCN2 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-generation sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect disease-causing variants in the HCN2 gene, confirm a clinical diagnosis of HCN2-related epilepsy, assist in treatment planning, and enable genetic counselling and cascade testing of at-risk family members.
- Test Code
- 4080
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt.
- Fasting Required
- No
- Method
- Next-generation sequencing (NGS)
Sample Collection
No special preparation or fasting is required. A genetic counselling session will be conducted either before or after the test to obtain informed consent and a pedigree chart.
Method: Venipuncture or finger prick
Laboratory Analysis
A nurse or phlebotomist will collect approximately 5 mL of peripheral venous blood in an EDTA vacutainer. If an FTA card is used, a drop of blood from a finger prick is placed on the card and dried.
Report Delivery
There are no activity restrictions. Patients can resume normal daily routine immediately.
Timeline: 3 to 4 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect disease-causing variants in the HCN2 gene, confirm a clinical diagnosis of HCN2-related epilepsy, assist in treatment planning, and enable genetic counselling and cascade testing of at-risk family members.
How to Prepare
- Verify patient identity
- Use EDTA anticoagulant for whole blood
- If FTA card, allow blood spot to dry completely before packaging
- Label all samples with patient name and date of birth
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"HCN2 gene testing is recommended when epilepsy is suspected to be genetic in origin. Early identification of the causative variant helps guide therapy and family counselling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted blood sample
- Haemolysed sample
- Sample without label or test requisition form
- Insufficient volume
Understanding Your Results
No pathogenic variant detected
No HCN2-related genetic cause identified; other genes may be involved.
Pathogenic variant detected
Confirms genetic aetiology for epilepsy; family screening is recommended.
Variant of uncertain significance (VUS)
Clinical significance is unclear; further functional studies and family analysis may help.
If you or a relative have symptoms of epilepsy and are planning genetic testing, consult a neurologist or a clinical geneticist. If a VUS is reported, genetic counselling is strongly advised.
Limitations
- ⚠Only HCN2 gene is examined; other genetic causes may be missed.
- ⚠Large gene rearrangements may not be detected by standard NGS panels.
- ⚠A negative result does not eliminate a genetic cause.
- ⚠Variant of uncertain significance may require segregation analysis.
Risks & Considerations
- ●Localised pain at the injection site
- ●Bruising or haematoma formation
- ●Light-headedness or fainting during blood collection
Interfering Factors
- ●Sample degradation due to improper storage
- ●Maternal cell contamination in prenatal samples
- ●PCR amplification errors
- ●Very rare mosaicism may not be detected
Frequently Asked Questions
What is the HCN2 gene and how is it related to epilepsy?
What symptoms are associated with HCN2 gene epilepsy?
How is HCN2 gene epilepsy diagnosed?
What is the cost of the HCN2 NGS genetic test at DNA Labs India?
What type of sample is needed for this test?
Is fasting required before the test?
What is the turnaround time for the test report?
Will I receive the raw data files?
How is the HCN2 NGS test performed?
Can genetic testing confirm HCN2-related epilepsy?
Are there any limitations to this test?
Do I need genetic counselling before the test?
Related Tests
Angelman Syndrome Test
₹10,000Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test
₹14,000Episodic Ataxia Type 1 Hotspot Test
₹11,500Episodic Ataxia Comprehensive Profile Hotspot Test
₹16,000Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test
₹7,500Analyzer 18 SMA 18 Test Panel
₹1,755Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.