Histopathology Kidney Biopsy Panel 3 Test
Short Name: Kidney Biopsy Panel 3
Also known as: Kidney Biopsy Panel 3, Renal Biopsy Histopathology Panel, Kidney Tissue Analysis Panel 3, Comprehensive Renal Biopsy Panel
Histopathology Kidney Biopsy Panel 3 Test test available at DNA Labs India for ₹13,500. Uses Cryoprocessing, Fluorescence Microscopy, Light Microscopy, Immunohistochemistry (IHC), Digital Photography, Transmission Electron Microscopy (TEM) on Kidney Biopsy Tissue Specimens (3 specimens required) samples. Results in Sample processing begins daily by 6 PM upon specimen receipt. The complete report is delivered within 22 working days through the online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The Histopathology Kidney Biopsy Panel 3 Test is performed for the evaluation of patients with undiagnosed kidney disease. It helps in following the course of therapy or disease progression and diagnoses diseases caused by immune mechanisms. For transplanted kidneys, this panel is particularly important in the determination of acute rejection, infection, or recurrent disease. Transmission electron microscopy (TEM) is critical in diagnosing conditions where pathological features are not discernible under light microscopy alone, including Alport disease, thin basement membrane disease, fibrillary glomerulonephritis, immunotactoid glomerulonephritis, and dense deposit disease. TEM is also useful in renal allografts to diagnose recurrence or de novo development of diseases.
- Test Code
- 776
- Price
- ₹13,500
- Sample Type
- Kidney Biopsy Tissue Specimens (3 specimens required)
- Result Time
- Sample processing begins daily by 6 PM upon specimen receipt. The complete report is delivered within 22 working days through the online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Cryoprocessing, Fluorescence Microscopy, Light Microscopy, Immunohistochemistry (IHC), Digital Photography, Transmission Electron Microscopy (TEM)
Sample Collection
A brief clinical history must be provided in the Renal Biopsy-Native Kidneys Requisition Form (Form 5) or Renal Allograft/Transplant Biopsy Requisition Form (Form 6). This is mandatory before sample submission. Inform the physician about any anticoagulant or antiplatelet medications being taken, as these may need to be adjusted before the biopsy procedure.
Method: Kidney biopsy procedure performed by a nephrologist or urologist
Laboratory Analysis
The kidney biopsy is performed by a qualified nephrologist or urologist, typically under ultrasound or CT guidance. Three separate tissue specimens are collected and placed in their respective preservative solutions: buffered normal saline for DIF, 10% formal saline for histopathology, and 3% buffered glutaraldehyde for electron microscopy.
Report Delivery
Specimens should be shipped refrigerated to the laboratory. Patients should be monitored post-biopsy for signs of bleeding, pain, or other complications. Results will be available within 22 working days through the online portal, email, or WhatsApp.
Timeline: Sample processing begins daily by 6 PM upon specimen receipt. The complete report is delivered within 22 working days through the online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The Histopathology Kidney Biopsy Panel 3 Test is performed for the evaluation of patients with undiagnosed kidney disease. It helps in following the course of therapy or disease progression and diagnoses diseases caused by immune mechanisms. For transplanted kidneys, this panel is particularly important in the determination of acute rejection, infection, or recurrent disease. Transmission electron microscopy (TEM) is critical in diagnosing conditions where pathological features are not discernible under light microscopy alone, including Alport disease, thin basement membrane disease, fibrillary glomerulonephritis, immunotactoid glomerulonephritis, and dense deposit disease. TEM is also useful in renal allografts to diagnose recurrence or de novo development of diseases.
How to Prepare
- Submit 3 separate kidney biopsy specimens as indicated on the requisition form
- Place 1 specimen in buffered normal saline for DIF studies
- Place 1 specimen in 10% formal saline for histopathology examination
- Place 1 specimen in 3% buffered glutaraldehyde solution (available from LPL) for electron microscopy
- Ship all specimens refrigerated to ensure tissue integrity
- Complete the Renal Biopsy-Native Kidneys Requisition Form (Form 5) or Renal Allograft/Transplant Biopsy Requisition Form (Form 6) with a brief clinical history — this is mandatory
- Ensure specimens are clearly labelled with patient details and specimen type
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"As a nephrologist, I recommend the Histopathology Kidney Biopsy Panel 3 for patients presenting with unexplained proteinuria, persistent hematuria, unexplained decline in renal function, or suspected glomerulonephritis. This comprehensive panel is particularly valuable for transplant recipients where accurate diagnosis of acute rejection, infection, or recurrent disease is essential for guiding immunosuppressive therapy. The inclusion of transmission electron microscopy is critical for identifying ultrastructural changes characteristic of conditions such as Alport disease, thin basement membrane disease, and fibrillary glomerulonephritis, which cannot be reliably diagnosed by light microscopy alone. Early and precise diagnosis through this panel enables timely and targeted treatment, improving long-term kidney outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Specimens not preserved in the correct solutions as specified
- Insufficient tissue quantity for all panel components
- Missing or incomplete requisition form (Form 5 or Form 6)
- Specimens received without proper labelling or identification
- Specimens shipped at room temperature when refrigerated transport is required
- Exceeding recommended specimen stability timeframes
Understanding Your Results
No significant histopathological abnormalities detected in glomeruli, tubules, interstitium, or vessels. Correlate with clinical presentation.
No immune complex or complement deposition detected. This finding may be seen in non-immune-mediated kidney diseases.
Findings are consistent with IgA nephropathy. Correlation with light microscopy and clinical history is recommended.
May indicate antibody-mediated rejection in the transplanted kidney. Clinical correlation and donor-specific antibody testing are recommended.
Suggests polyomavirus-associated nephropathy (BK virus nephropathy), particularly relevant in transplant recipients. Immunosuppressive therapy may need adjustment.
May indicate thin basement membrane disease (benign familial hematuria) or early Alport syndrome. Clinical and genetic correlation is advised.
Suggests immune complex-mediated disease. Location of deposits (subepithelial, subendothelial, mesangial) helps classify the specific glomerular disease.
May indicate fibrillary glomerulonephritis or immunotactoid glomerulonephritis. Further characterization with immunohistochemistry is recommended.
Consult your nephrologist or treating physician if you experience symptoms such as persistent swelling in the legs or feet, foamy urine, blood in urine, unexplained fatigue, decreased urine output, or rising blood pressure. If you have a kidney transplant and experience decreased urine output or rising creatinine levels, seek immediate medical evaluation. Always discuss biopsy results with your doctor for appropriate clinical interpretation and treatment planning.
Limitations
- ⚠This test requires an invasive biopsy procedure which carries inherent procedural risks
- ⚠Adequate tissue sample is essential; insufficient specimens may lead to inconclusive results
- ⚠Results must be correlated with clinical history, laboratory findings, and imaging studies for definitive diagnosis
- ⚠Some conditions may require follow-up biopsies for disease monitoring
- ⚠Turnaround time of 22 working days may not be suitable for acute emergencies requiring immediate diagnosis
Risks & Considerations
- ●Pain or discomfort at the biopsy site
- ●Bleeding from the biopsy site (most common complication)
- ●Blood in urine (hematuria) which usually resolves within a few days
- ●Rare risk of arteriovenous fistula formation at the biopsy site
- ●Infection at the biopsy site (rare with proper technique)
- ●Very rare risk of pneumothorax if the biopsy is guided near the lower ribs
Interfering Factors
- ●Improper tissue fixation or preservation may compromise sample quality
- ●Delay in specimen transport may affect ultrastructural integrity for electron microscopy
- ●Insufficient tissue sample may limit the completeness of the panel evaluation
- ●Previous use of certain medications may alter tissue morphology and immune deposit patterns
Compare With Similar Tests
| Test | Histopathology Kidney Biopsy Panel 3 Test | Kidney Function Test (KFT/RFT) | Urine Routine and Microscopy | Serum Creatinine and eGFR | Complement Levels (C3, C4) Blood Test |
|---|---|---|---|---|---|
| Comparison | Histopathology Kidney Biopsy Panel 3 Test |
Frequently Asked Questions
What is the Histopathology Kidney Biopsy Panel 3 Test?
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What is the cost of the Histopathology Kidney Biopsy Panel 3 Test in India?
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What is Transmission Electron Microscopy (TEM) and why is it important in this panel?
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