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HLA-DRB1*1501 Genotyping (Multiple Sclerosis) Test

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HLA-DRB1*1501 Genotyping (Multiple Sclerosis) Test

Short Name: HLA-DRB1*1501 Genotyping

Also known as: HLA-DRB1*1501 Test, MS Genetic Risk Test, HLA Typing for Multiple Sclerosis

HLA-DRB1*1501 Genotyping (Multiple Sclerosis) Test test available at DNA Labs India for ₹5,250. Uses Sanger Sequencing on Peripheral blood samples. Results in Reports are typically available within 10 days after sample collection.. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of HLA-DRB1*1501 genotyping is to detect the presence of the HLA-DRB1*1501 gene variant, which is linked to a higher genetic risk for Multiple Sclerosis. This test helps in early risk assessment, supports diagnostic evaluation for individuals with symptoms or family history, and provides valuable information for genetic counseling and preventive healthcare planning.

Test Code
3047
Price
₹5,250
Sample Type
Peripheral blood
Result Time
Reports are typically available within 10 days after sample collection.
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

Ensure a valid doctor's prescription is available. No specific fasting is required unless advised by the physician. Inform the healthcare provider about any medications or health conditions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture from a vein in your arm using a sterile needle and syringe. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply gentle pressure to the puncture site with a cotton ball to prevent bleeding and bruising. Resume normal activities immediately, avoiding heavy lifting with the affected arm for a few hours.

Timeline: Reports are typically available within 10 days after sample collection.

Patient Instructions

1
Before the Test:Same as before_collection: Ensure prescription is available and follow any specific instructions from your doctor.
2
During the Test:Same as during_collection: Blood sample collection via venipuncture.
3
After the Test:Same as after_collection: Apply pressure to the puncture site and resume normal activities.

About This Test

Who Should Get This Test

The purpose of HLA-DRB1*1501 genotyping is to detect the presence of the HLA-DRB1*1501 gene variant, which is linked to a higher genetic risk for Multiple Sclerosis. This test helps in early risk assessment, supports diagnostic evaluation for individuals with symptoms or family history, and provides valuable information for genetic counseling and preventive healthcare planning.

How to Prepare

  • Obtain a doctor's prescription prior to sample collection
  • Blood sample will be drawn from a vein in the arm
  • Store the sample in a cool pack during transport to the laboratory

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is crucial for individuals with a family history of Multiple Sclerosis, aiding in early risk assessment and guiding preventive care strategies."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypePeripheral blood
Sample Volume2ml
ContainerEDTA Vacutainer
Collection MethodVenipuncture

Sample Stability

Stable for 24 hours at 2-8°C when stored in EDTA vacutainer
For long-term storage, keep at -20°C to preserve DNA integrity
Sample Rejection Criteria:
  • Insufficient sample volume (less than 2ml)
  • Hemolyzed, lipemic, or contaminated sample
  • Improperly labeled or unlabeled sample container

Understanding Your Results

Results from HLA-DRB1*1501 genotyping indicate whether the gene variant is present. A positive result suggests an increased genetic predisposition to Multiple Sclerosis, but it is not diagnostic. Clinical evaluation is necessary for confirmation.
📊

Detected

Presence of HLA-DRB1*1501 gene variant, indicating increased genetic risk for Multiple Sclerosis. Consult a neurologist for further evaluation and monitoring.

📊

Not Detected

Absence of the HLA-DRB1*1501 gene variant, suggesting lower genetic risk. However, MS can still develop due to other genetic or environmental factors.

⚠️ When to Consult a Doctor:

If the test result is positive, consult a neurologist promptly for comprehensive evaluation. If symptoms persist despite a negative result, seek medical advice to explore other potential causes.

Limitations

  • ⚠This test indicates genetic risk only and does not diagnose Multiple Sclerosis
  • ⚠Clinical correlation with symptoms, medical history, and other diagnostic tests is essential
  • ⚠False positives or negatives may occur due to technical or biological factors

Risks & Considerations

  • ●Minor bruising or pain at the blood draw site
  • ●Rare risk of infection at the puncture site
  • ●Slight dizziness or lightheadedness during venipuncture

Interfering Factors

  • ●Sample contamination during collection or processing
  • ●Improper DNA extraction techniques
  • ●Hemolyzed or lipemic blood sample

Frequently Asked Questions

What is HLA-DRB1*1501 genotyping?
HLA-DRB1*1501 genotyping is a genetic test that detects the presence of the HLA-DRB1*1501 gene variant, which is associated with an increased risk of developing Multiple Sclerosis.
Why is this test important for Multiple Sclerosis?
This test helps identify individuals at higher genetic risk for MS, enabling early monitoring, informed diagnostic pathways, and proactive healthcare planning.
How is the test performed?
The test involves collecting a blood sample, extracting DNA, and using Sanger Sequencing to analyze the HLA-DRB1 gene for the *1501 variant.
What is the cost of the test at DNA Labs India?
The cost of HLA-DRB1*1501 genotyping at DNA Labs India is INR 5250, which includes sample collection, analysis, and a detailed report.
Is fasting required for this test?
No, fasting is not required for this test. However, follow any specific instructions provided by your doctor.
How long does it take to get results?
Results are typically available within 10 days after sample collection.
What does a positive result mean?
A positive result indicates the presence of the HLA-DRB1*1501 gene variant, suggesting an increased genetic risk for Multiple Sclerosis. It does not confirm a diagnosis of MS.
Can this test diagnose Multiple Sclerosis?
No, this test only indicates genetic risk. Diagnosis of MS requires clinical evaluation, MRI, and other tests as per medical guidelines.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India for added convenience.
What are the symptoms of Multiple Sclerosis?
Common symptoms include vision problems, muscle weakness, numbness or tingling, fatigue, difficulty with coordination and balance, and cognitive issues.
How accurate is this test?
The test uses Sanger Sequencing, which is highly accurate for detecting specific gene variants. However, genetic risk does not guarantee disease development.
Do I need a doctor's prescription for this test?
Yes, a doctor's prescription is required for this test, except in cases of surgery, pregnancy, or travel abroad.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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