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HLA - Narcolepsy (DRB115 DQB106:02 DQA1*01:02) Test

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HLA - Narcolepsy (DRB115 DQB106:02 DQA1*01:02) Test

Short Name: HLA Narcolepsy Test

Also known as: HLA Typing for Narcolepsy, Narcolepsy Genetic Test

HLA - Narcolepsy (DRB115 DQB106:02 DQA1*01:02) Test test available at DNA Labs India for ₹8,500. Uses Sequencing Based Typing (SBT) on Whole Blood samples. Results in 10-12 days. Free home collection in 300+ cities across India.

Genetic TestAdolescents and Adults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of the HLA Narcolepsy test is to detect genetic markers (DRB1*15, DQB1*06:02, DQA1*01:02) that indicate an increased risk for narcolepsy, aiding in diagnosis when combined with clinical symptoms and sleep studies.

Test Code
797
Price
₹8,500
Sample Type
Whole Blood
Result Time
10-12 days
Fasting Required
No
Method
Sequencing Based Typing (SBT)
Step 1

Sample Collection

No special preparation required.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities immediately.

Timeline: 10-12 days

Patient Instructions

1
Before the Test:No special preparation required. Inform your doctor about any medications or health conditions.
2
During the Test:A small blood sample will be collected from your arm vein. The process is quick and typically painless.
3
After the Test:You may resume normal activities. Results will be available in 10-12 days via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of the HLA Narcolepsy test is to detect genetic markers (DRB1*15, DQB1*06:02, DQA1*01:02) that indicate an increased risk for narcolepsy, aiding in diagnosis when combined with clinical symptoms and sleep studies.

How to Prepare

  • Ensure the sample is labeled correctly with patient details.
  • Ship the sample refrigerated; do not freeze.
  • Use the specified tubes: Lavender Top (EDTA) or Yellow Top (ACD).

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"As a neurologist, I recommend the HLA Narcolepsy test for patients with symptoms of excessive daytime sleepiness and cataplexy to confirm genetic susceptibility and guide treatment."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume4 mL (min 3 mL) or 6 mL (min 3 mL)
ContainerLavender Top (EDTA) tube or Yellow Top (ACD) tube
Collection MethodVenipuncture

Sample Stability

Refrigerated: 96 hours
Room Temperature: Not recommended
Frozen: Not recommended
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrect anticoagulant or container
  • Sample not refrigerated or improperly stored

Understanding Your Results

The HLA Narcolepsy test detects specific genetic markers associated with narcolepsy. Results indicate genetic susceptibility and should be interpreted alongside clinical symptoms and other diagnostic findings.
📊

Positive for DRB1*15, DQB1*06:02, and/or DQA1*01:02

Increased genetic risk for narcolepsy. Correlate with symptoms like excessive daytime sleepiness and cataplexy, and consider sleep studies for confirmation.

📊

Negative for all markers

Lower genetic susceptibility to narcolepsy. However, narcolepsy can still occur due to other factors; clinical evaluation remains essential.

⚠️ When to Consult a Doctor:

If you experience excessive daytime sleepiness, cataplexy, hallucinations, sleep paralysis, or other symptoms of narcolepsy, consult a neurologist or sleep specialist for evaluation.

Limitations

  • ⚠Does not confirm narcolepsy alone; must be correlated with clinical evaluation and sleep studies.
  • ⚠Presence of HLA markers indicates genetic susceptibility but not certainty of developing narcolepsy.
  • ⚠Test may not detect all genetic variants associated with narcolepsy.

Risks & Considerations

  • ●Minimal risk: slight pain, bruising, or swelling at the blood draw site.
  • ●Rare: infection or excessive bleeding at the puncture site.

Interfering Factors

  • ●Hemolyzed or lipemic samples
  • ●Incorrect sample storage or shipping
  • ●Contaminated samples

Compare With Similar Tests

TestHLA - Narcolepsy (DRB115 DQB106:02 DQA1*01:02) Test
ComparisonHLA - Narcolepsy (DRB115 DQB106:02 DQA1*01:02) Test

Frequently Asked Questions

What is the HLA Narcolepsy test?
It is a genetic test that analyzes HLA genes (DRB1*15, DQB1*06:02, DQA1*01:02) to assess genetic susceptibility to narcolepsy.
Why is this test performed?
To support the diagnosis of narcolepsy in individuals with symptoms like excessive daytime sleepiness and cataplexy, especially when combined with sleep studies.
What genes are analyzed in this test?
The test specifically looks for variations in the DRB1*15, DQB1*06:02, and DQA1*01:02 genes on chromosome 6.
How is the test conducted?
A blood sample is collected from your arm and analyzed using Sequencing Based Typing (SBT) in a laboratory.
What does a positive result mean?
A positive result indicates the presence of HLA markers associated with increased genetic risk for narcolepsy, but it does not confirm the disorder alone.
What is the cost of the HLA Narcolepsy test?
The test costs INR 8500, which includes free home sample collection across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities nationwide.
How long does it take to get the results?
Results are typically available within 10-12 days after sample collection.
Do I need to fast before the test?
No, there is no fasting or special preparation required for this test.
What are the symptoms of narcolepsy?
Common symptoms include excessive daytime sleepiness, cataplexy, hallucinations, sleep paralysis, disrupted nighttime sleep, and automatic behavior.
How accurate is the HLA Narcolepsy test?
The test is highly accurate in detecting the specified HLA markers, but it should be interpreted alongside clinical evaluation and other diagnostics for a comprehensive diagnosis.
Can this test be used for children?
Narcolepsy often begins in adolescence or early adulthood, so the test may be suitable for older children and adults. Consult a healthcare provider for personalized advice.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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