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HLA - Panel Reactive IgG Antibodies (PRA) Class I Quantitative Test

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HLA - Panel Reactive IgG Antibodies (PRA) Class I Quantitative Test

Short Name: HLA PRA Class I Test

Also known as: Panel Reactive Antibody Test Class I

HLA - Panel Reactive IgG Antibodies (PRA) Class I Quantitative Test test available at DNA Labs India for ₹15,000. Uses Luminex X-Map technology on Serum samples. Results in 10-12 days. Free home collection in 300+ cities across India.

Diagnostic TestAdults🏠 Home Collection

🩺 Medically Reviewed By

Overview

The primary purpose of the HLA PRA Class I Quantitative Test is to assess the level of pre-formed antibodies against HLA Class I antigens in potential organ transplant recipients. This helps in determining the risk of acute rejection and guides decisions on donor selection and immunosuppressive therapy. It is particularly vital for kidney transplant patients to ensure long-term graft survival.

Test Code
794
Price
₹15,000
Sample Type
Serum
Result Time
10-12 days
Fasting Required
No
Method
Luminex X-Map technology
Step 1

Sample Collection

Collect specimen preferably 48 hours after dialysis. Provide brief clinical history.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard venipuncture procedure for blood collection.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising; resume normal activities unless advised otherwise.

Timeline: 10-12 days

Patient Instructions

1
Before the Test:Collect specimen preferably 48 hours after dialysis. Provide brief clinical history.
2
During the Test:A blood sample will be drawn from a vein in your arm using standard venipuncture.
3
After the Test:No specific aftercare is required; you can resume normal activities immediately.

About This Test

Who Should Get This Test

The primary purpose of the HLA PRA Class I Quantitative Test is to assess the level of pre-formed antibodies against HLA Class I antigens in potential organ transplant recipients. This helps in determining the risk of acute rejection and guides decisions on donor selection and immunosuppressive therapy. It is particularly vital for kidney transplant patients to ensure long-term graft survival.

How to Prepare

  • Collect specimen preferably 48 hours after dialysis.
  • Provide brief clinical history to the laboratory.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume3 mL (1.5 mL min.)
ContainerSST
Collection MethodVenipuncture

Sample Stability

Room Temperature2 hours
Refrigerator1 week
Frozen4 weeks

Understanding Your Results

The results of the HLA PRA Class I Quantitative Test are interpreted based on the percentage of panel reactive antibodies or MFI values. Higher values indicate greater sensitization and increased risk of transplant rejection.
📊

Low PRA (<10%)

Low risk of rejection; good compatibility for transplantation.

📊

Moderate PRA (10-50%)

Moderate risk; careful donor selection and monitoring required.

📊

High PRA (>50%)

High risk of rejection; intensive immunosuppression and desensitization protocols may be needed.

⚠️ When to Consult a Doctor:

Consult your transplant specialist or immunologist if you have high PRA levels or before proceeding with organ transplantation to discuss management options.

Risks & Considerations

  • Minor bruising at puncture site
  • Slight discomfort during blood draw
  • Rare risk of infection

Frequently Asked Questions

What is the HLA PRA Class I Quantitative Test?
It is a blood test that measures the amount of IgG antibodies against Human Leukocyte Antigen (HLA) Class I antigens, used to assess organ transplant compatibility.
Why is this test important for transplant patients?
High levels of HLA antibodies increase the risk of organ rejection after transplantation, so this test helps in evaluating compatibility and managing rejection risk.
How is the sample collected for this test?
A blood sample of 3 mL is collected via venipuncture into a Serum Separator Tube (SST), preferably 48 hours after dialysis if applicable.
What does a high PRA value indicate?
A high PRA value suggests a higher risk of transplant rejection due to pre-existing antibodies, requiring careful donor matching and immunosuppressive therapy.
Is any preparation needed before the test?
Collect the specimen preferably 48 hours after dialysis and provide a brief clinical history to the healthcare provider.
What is the cost of the HLA PRA Class I Quantitative Test?
The test costs INR 15000 at DNA Labs India, with free home sample collection available across India.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 10-12 days and can be accessed via online portal, email, or WhatsApp.
Are there any risks associated with this test?
The test involves a standard blood draw, which may cause minor bruising or discomfort at the puncture site, but serious risks are rare.
Can this test be performed during pregnancy?
Consult with your healthcare provider, as pregnancy may affect antibody levels, but the test itself is not contraindicated.
What should I do if my PRA levels are high?
High PRA levels indicate increased rejection risk; discuss with your transplant team for appropriate management and donor selection strategies.
How accurate is the Luminex X-Map technology used in this test?
Luminex X-Map technology provides high sensitivity and specificity for detecting HLA antibodies, ensuring reliable and accurate results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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