IgA Subclasses Test
Short Name: IgA Subclasses
Also known as: IgA1 and IgA2 Test, Immunoglobulin A Subclasses Test, IgA Subclass Panel, Serum IgA Subclasses
IgA Subclasses Test test available at DNA Labs India for ₹15,000. Uses Nephelometry on Serum samples. Results in Samples are dispatched by the 7th of each month. Reports are typically available within 2 to 3 weeks after sample receipt at the reference laboratory. Reports will be delivered via the Online Portal, Email, and WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The IgA Subclasses Test is performed to measure IgA1, IgA2, and total IgA levels in the blood. It aids in diagnosing IgA subclasses deficiency, evaluating patients with recurrent infections, assessing IgA nephropathy risk, identifying individuals at risk for anaphylactic transfusion reactions, and monitoring mucosal immune function. This test helps clinicians differentiate between systemic and mucosal immune involvement and guides appropriate treatment strategies for immunodeficiency and kidney disorders.
- Test Code
- 853
- CPT Code
- 82784
- ICD Code
- D80.2
- Price
- ₹15,000
- Sample Type
- Serum
- Result Time
- Samples are dispatched by the 7th of each month. Reports are typically available within 2 to 3 weeks after sample receipt at the reference laboratory. Reports will be delivered via the Online Portal, Email, and WhatsApp.
- Fasting Required
- No
- Method
- Nephelometry
Sample Collection
Ensure the duly filled Test Send Out Consent Form (Form 35) is completed prior to sample collection. Inform the phlebotomist about any current medications, recent immunoglobulin therapy, or blood transfusions. No fasting is required for this test.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of blood via venipuncture from a vein in the arm. The blood will be collected into a Serum Separator Tube (SST). The process typically takes less than 5 minutes and may involve minimal discomfort at the puncture site.
Report Delivery
After sample collection, gentle pressure will be applied to the puncture site with a cotton ball or bandage. Mild bruising may occur and typically resolves within a few days. The serum sample will be separated, processed, and shipped under refrigerated or frozen conditions to the testing facility.
Timeline: Samples are dispatched by the 7th of each month. Reports are typically available within 2 to 3 weeks after sample receipt at the reference laboratory. Reports will be delivered via the Online Portal, Email, and WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The IgA Subclasses Test is performed to measure IgA1, IgA2, and total IgA levels in the blood. It aids in diagnosing IgA subclasses deficiency, evaluating patients with recurrent infections, assessing IgA nephropathy risk, identifying individuals at risk for anaphylactic transfusion reactions, and monitoring mucosal immune function. This test helps clinicians differentiate between systemic and mucosal immune involvement and guides appropriate treatment strategies for immunodeficiency and kidney disorders.
How to Prepare
- Complete the Test Send Out Consent Form (Form 35) — this is mandatory for sample processing
- No fasting is required prior to sample collection
- Inform the collection team about any recent blood transfusions or immunoglobulin therapy
- A minimum of 1 mL serum (2 mL blood recommended) is required from 1 SST
- Sample must be shipped refrigerated or frozen to maintain stability
- Avoid strenuous physical activity immediately before sample collection
- Stay well hydrated before the blood draw
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"IgA subclasses testing is clinically important in the evaluation of patients presenting with recurrent infections, suspected immunodeficiency, and IgA nephropathy. IgA nephropathy is the most common primary glomerulonephritis worldwide and is typically associated with aberrantly glycosylated IgA1. Quantifying IgA1 and IgA2 separately allows nephrologists and immunologists to distinguish between mucosal and systemic IgA involvement, assess subclass-specific deficiencies, and evaluate risk for adverse transfusion reactions. This test, performed via nephelometry, provides precise quantitative results and should always be interpreted alongside clinical findings, family history, and complementary laboratory investigations such as total immunoglobulin levels and renal function panels."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received without a duly filled Test Send Out Consent Form (Form 35)
- Insufficient sample volume (less than 1 mL serum)
- Improperly labeled or unlabeled sample
- Sample received at room temperature beyond 6 hours post-collection
- Hemolyzed, lipemic, or contaminated serum samples
- Sample shipped without proper cold chain maintenance
Understanding Your Results
All IgA subclass levels are within the expected reference ranges, suggesting adequate IgA-mediated immune function. Clinical correlation is recommended if symptoms persist.
May indicate selective IgA1 subclass deficiency, which is associated with recurrent sinopulmonary infections and gastrointestinal infections. Further immunological workup is recommended.
May indicate IgA2 subclass deficiency, which can affect mucosal immunity particularly in the gastrointestinal tract. Increased susceptibility to mucosal infections may be observed.
Complete IgA subclass deficiency may indicate a more significant immunodeficiency. Patients may be at increased risk for recurrent infections, autoimmune disorders, and anaphylactic transfusion reactions.
Elevated IgA1, particularly aberrantly glycosylated IgA1, may be associated with IgA nephropathy — the most common primary glomerulonephritis. Nephrology evaluation and renal biopsy may be warranted.
Elevated total IgA may be seen in chronic liver disease, chronic infections, autoimmune conditions, or IgA myeloma. Clinical correlation with liver function tests and serum protein electrophoresis is advised.
Consult a nephrologist or immunologist if your IgA subclass levels are outside the reference range, if you experience recurrent respiratory or gastrointestinal infections, if you have a family history of immunodeficiency, or if you have been diagnosed with or are suspected to have IgA nephropathy. Early evaluation and management can help prevent complications such as chronic kidney disease, autoimmune disorders, and severe allergic reactions.
Limitations
- ⚠This test measures serum IgA subclasses only and does not evaluate secretory IgA
- ⚠Results should be interpreted alongside clinical findings and other immunological tests
- ⚠Reference ranges may vary slightly based on age, sex, and laboratory methodology
- ⚠Subclass deficiency may exist even when total IgA levels are within normal range
- ⚠The test is a send-out test with a turnaround time of 2 to 3 weeks from sample dispatch
Risks & Considerations
- ●Minor bruising or swelling at the venipuncture site
- ●Brief pain or discomfort during needle insertion
- ●Rarely, dizziness or lightheadedness during or after blood draw
- ●Very rare risk of infection at the puncture site
Interfering Factors
- ●Recent immunoglobulin therapy or blood transfusion may alter IgA levels
- ●Immunosuppressive medications can lower IgA subclass levels
- ●Acute infections may cause transient fluctuations in immunoglobulin levels
- ●Severely lipemic or hemolyzed serum samples may affect nephelometry accuracy
- ●Sample handling delays or improper storage may compromise results
Compare With Similar Tests
| Test | IgA Subclasses Test | Immunoglobulin Levels Test | Immunodeficiency Panel | Serum Protein Electrophoresis |
|---|---|---|---|---|
| Comparison | IgA Subclasses Test |
Frequently Asked Questions
What is the IgA Subclasses Test?
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What is the difference between IgA1 and IgA2?
What is IgA nephropathy and how is it related to this test?
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