High Resolution HLA Typing Test
Short Name: HLA Typing (Single Person)
Also known as: High Resolution HLA Typing, NGS HLA Typing, HLA-A/B/C/DRB1/DQB1/DPB1 Typing
High Resolution HLA Typing Test test available at DNA Labs India for ₹8,000. Uses Illumina Next-Generation Sequencing (NGS), Locus-specific long-range PCR on Whole Blood samples. Results in Results are typically available within 10-12 working days after the sample reaches the lab.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of high-resolution HLA typing is to determine the exact allele-level HLA profile of an individual, which is essential for: 1) Matching donors and recipients in hematopoietic stem cell or solid organ transplantation, 2) Assessing genetic risk for autoimmune diseases like ankylosing spondylitis (HLA-B27) and celiac disease (HLA-DQ2/DQ8), 3) Screening for drug hypersensitivity reactions such as abacavir (HLA-B*57:01) and carbamazepine (HLA-B*15:02), 4) Research and population studies. The NGS-based approach ensures high accuracy and eliminates ambiguities, providing clinically actionable results.
- Test Code
- 6287
- CPT Code
- 81375
- ICD Code
- Z01.89
- Price
- ₹8,000
- Sample Type
- Whole Blood
- Result Time
- Results are typically available within 10-12 working days after the sample reaches the lab.
- Fasting Required
- No
- Method
- Illumina Next-Generation Sequencing (NGS), Locus-specific long-range PCR
Sample Collection
No special preparation is required. Inform your physician about any recent blood transfusions or bone marrow transplants.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect 5 mL of whole blood into an EDTA tube. The procedure takes about 5 minutes.
Report Delivery
You can resume normal activities immediately. The sample will be transported to the lab at 2-8°C.
Timeline: Results are typically available within 10-12 working days after the sample reaches the lab.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of high-resolution HLA typing is to determine the exact allele-level HLA profile of an individual, which is essential for: 1) Matching donors and recipients in hematopoietic stem cell or solid organ transplantation, 2) Assessing genetic risk for autoimmune diseases like ankylosing spondylitis (HLA-B27) and celiac disease (HLA-DQ2/DQ8), 3) Screening for drug hypersensitivity reactions such as abacavir (HLA-B*57:01) and carbamazepine (HLA-B*15:02), 4) Research and population studies. The NGS-based approach ensures high accuracy and eliminates ambiguities, providing clinically actionable results.
How to Prepare
- Use EDTA (purple-top) tube
- Ensure proper mixing of blood with anticoagulant
- Label the tube with patient ID and date
- Transport at 2-8°C within 24 hours
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"High-resolution HLA typing is essential for accurate transplant matching and pharmacogenetic screening. NGS-based typing eliminates ambiguity and provides definitive allele-level results."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect tube (e.g., heparin or citrate)
- Sample older than 48 hours without proper storage
Understanding Your Results
High compatibility, lower risk of graft-versus-host disease
Increased risk; ~90% of patients are B27 positive
Genetic predisposition; absence virtually rules out disease
High risk; abacavir should be avoided
High risk for Stevens-Johnson syndrome in Asian populations
Consult your physician if you have a positive result for HLA-B27, HLA-DQ2/DQ8, or HLA-B*57:01, as it may require further evaluation or changes in medication. For transplant candidates, discuss the results with your transplant coordinator.
Limitations
- ⚠This test does not cover all HLA loci (e.g., DRB3/4/5, DQA1) – only the six specified loci
- ⚠Rare or novel alleles may not be detected if not present in the reference database
- ⚠Results are for clinical interpretation and should be correlated with other findings
- ⚠Not a substitute for full HLA matching in complex transplant cases – additional testing may be required
Risks & Considerations
- ●Minimal risk of bruising or infection at the puncture site
- ●Rare possibility of fainting during blood draw
Interfering Factors
- ●Recent blood transfusion (within 2 weeks) may cause mixed cell populations
- ●Bone marrow transplantation can alter HLA type due to donor cells
- ●Clotted or hemolyzed samples may affect DNA quality
- ●Insufficient sample volume (<5 mL) may lead to inadequate DNA yield
Compare With Similar Tests
| Test | High Resolution HLA Typing Test | |||||
|---|---|---|---|---|---|---|
| Comparison | High Resolution HLA Typing Test |
Frequently Asked Questions
Why is NGS preferred over PCR-SSP for HLA typing?
How to read G-Codes in my HLA report?
Is home collection available for HLA tests in Tier-1 cities?
What diseases can HLA typing help diagnose or predict?
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What is the price of the test?
What sample is required?
Is this test suitable for children?
Can this test be used for prenatal diagnosis?
Does the report include NMDP codes?
What is the reference database version used?
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