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HOMA-IR Insulin Resistance Index C-Peptide Model Test

DNA Labs India | ISO 9001:2015 Certified

HOMA-IR Insulin Resistance Index C-Peptide Model Test

Short Name: HOMA-IR C-Peptide Model Test

Also known as: HOMA-IR Test, Insulin Resistance Index Test, C-Peptide Model Test

HOMA-IR Insulin Resistance Index C-Peptide Model Test test available at DNA Labs India for ₹1,322. Uses Hexokinase, CLIA on Plasma and Serum samples. Results in Same day reporting if sample collected before 4 PM.. Free home collection in 300+ cities across India.

Blood TestAdults🏠 Home Collection

🩺 Medically Reviewed By

Overview

This test is used to: *Measure fasting glucose and C-peptide levels *Assess beta-cell function *Evaluate insulin sensitivity *Calculate the HOMA-IR index for insulin resistance *Monitor treatment response in diabetic patients *Screen for prediabetes and type 2 diabetes risk.

Test Code
831
Price
₹1,322
Sample Type
Plasma and Serum
Result Time
Same day reporting if sample collected before 4 PM.
Fasting Required
Yes (8 hours)
Method
Hexokinase, CLIA
Step 1

Sample Collection

Overnight fasting for at least 8 hours is mandatory. Avoid eating or drinking anything except water during this period. Inform the lab about any medications or supplements you are taking.

Method: Venipuncture

Step 2

Laboratory Analysis

A healthcare professional will draw blood from a vein in your arm using a needle and syringe or vacutainer system. The process typically takes a few minutes.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball to stop bleeding. You may experience minor bruising or soreness, which should resolve quickly. Resume normal activities unless otherwise directed.

Timeline: Same day reporting if sample collected before 4 PM.

Patient Instructions

1
Before the Test:Ensure overnight fasting for 8-12 hours. Avoid alcohol and caffeine 24 hours before the test. Discuss any medications with your doctor.
2
During the Test:A blood sample will be drawn from your arm. You may feel a slight prick; the procedure is quick and minimally invasive.
3
After the Test:You can resume normal activities immediately. Apply pressure to the puncture site if needed. Results will be available same day.

About This Test

Who Should Get This Test

This test is used to: *Measure fasting glucose and C-peptide levels *Assess beta-cell function *Evaluate insulin sensitivity *Calculate the HOMA-IR index for insulin resistance *Monitor treatment response in diabetic patients *Screen for prediabetes and type 2 diabetes risk.

How to Prepare

  • Fast overnight for 8-12 hours before the test
  • Stay hydrated with water
  • Wear comfortable clothing with easy access to arms
  • Bring identification and doctor's prescription if available
  • Avoid strenuous exercise before the test

Doctor's Notes

Reviewed by — MBBS, MD (Biochemistry) · Reg. No. 21504

"Early detection of insulin resistance is key to preventing type 2 diabetes and related complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypePlasma and Serum
Sample Volume2 mL plasma (1 mL min.) from Grey Top tube and 2 mL serum (1 mL min.) from SST
ContainerGrey Top (Sodium fluoride) tube and Serum Separator Tube (SST)
Collection MethodVenipuncture

Sample Stability

Room Temperature6 hours
Refrigerator24 hours
Frozen1 week
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed, icteric, or lipemic samples
  • Improperly labeled or contaminated samples
  • Sample not collected under fasting conditions

Understanding Your Results

The HOMA-IR score is calculated from fasting glucose and C-peptide levels. A higher score indicates greater insulin resistance. Results should be interpreted in the context of the patient's overall health, symptoms, and other diagnostic tests.
📊

Normal insulin sensitivity

📊

Borderline insulin resistance; may indicate early risk

📊

Significant insulin resistance; higher risk for type 2 diabetes

⚠️ When to Consult a Doctor:

Consult a doctor if your HOMA-IR score is elevated (>2.0), or if you experience symptoms like persistent thirst, frequent urination, or unexplained weight loss. Also, seek medical advice if you have risk factors such as obesity or family history of diabetes.

Limitations

  • Not a standalone diagnostic tool; must be correlated with clinical symptoms and other tests
  • Reference ranges may vary by laboratory and population
  • May not accurately reflect insulin resistance in all individuals, e.g., those with liver disease

Risks & Considerations

  • Minor pain or bruising at the needle site
  • Lightheadedness or dizziness
  • Rare risk of infection or excessive bleeding

Interfering Factors

  • Recent meals or non-fasting state
  • Certain medications like corticosteroids or oral contraceptives
  • Acute illness or stress
  • Hemolyzed or lipemic samples

Compare With Similar Tests

TestHOMA-IR Insulin Resistance Index C-Peptide Model TestHOMA-IR with Insulin ModelFasting Glucose TestHbA1c TestOral Glucose Tolerance TestC-Peptide Test Alone
ComparisonHOMA-IR Insulin Resistance Index C-Peptide Model Test

Frequently Asked Questions

What is the HOMA-IR Insulin Resistance Index C-Peptide Model Test?
It is a blood test that measures insulin resistance by calculating the HOMA-IR score from fasting glucose and C-peptide levels.
Why is C-peptide used instead of insulin in this test?
C-peptide is a more stable marker of endogenous insulin production and is not affected by exogenous insulin administration, making it accurate for diabetic patients.
How do I prepare for the test?
Fast overnight for 8-12 hours, drink only water, and avoid strenuous activity. Inform the lab about any medications.
What does a high HOMA-IR score mean?
A high HOMA-IR score indicates insulin resistance, which increases the risk of type 2 diabetes and cardiovascular diseases.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort, but it is generally quick and well-tolerated.
How long does it take to get results?
Results are typically available the same day if the sample is collected before 4 PM.
Can I take this test if I am on insulin therapy?
Yes, the C-peptide model is specifically designed for patients on exogenous insulin as it measures endogenous insulin production.
What are normal HOMA-IR values?
Normal HOMA-IR values are typically less than 2.0, but ranges may vary by laboratory and population.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What other tests might my doctor recommend alongside this test?
Your doctor may recommend HbA1c, fasting glucose, lipid profile, or thyroid function tests for a comprehensive assessment.
How is the HOMA-IR score calculated?
The HOMA-IR score is calculated using the formula: (Fasting Glucose in mg/dL × Fasting C-Peptide in ng/mL) / 405.
What should I do if my test results show insulin resistance?
Consult your doctor immediately. They may suggest lifestyle changes, diet modifications, or medications to manage insulin resistance and prevent diabetes.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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