IHC ER-PR,HER2NEU Test
Short Name: IHC ER-PR, HER2NEU
Also known as: ER/PR/HER2 IHC, Breast Cancer Marker Testing, Hormone Receptor Testing
IHC ER-PR,HER2NEU Test test available at DNA Labs India for ₹4,500. Uses Immunohistochemistry on Tissue/ Paraffin block samples. Results in 3 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of IHC ER-PR, HER2NEU testing is to assess the presence and expression of estrogen receptor, progesterone receptor, and HER2NEU proteins in breast cancer tissue. This helps in classifying the cancer subtype, predicting response to specific therapies like hormone or targeted treatments, and guiding personalized treatment plans for improved patient outcomes.
- Test Code
- 3058
- Price
- ₹4,500
- Sample Type
- Tissue/ Paraffin block
- Result Time
- 3 days
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Ensure a doctor's prescription is available. Inform the lab of any medications or conditions. No specific fasting required.
Method: Biopsy or Surgical Specimen
Laboratory Analysis
A biopsy or surgical sample is collected by a healthcare professional, typically under local anesthesia, and placed in 10% neutral buffered formalin.
Report Delivery
The sample is sent to the lab for processing. Monitor the biopsy site for any signs of infection or bleeding.
Timeline: 3 days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of IHC ER-PR, HER2NEU testing is to assess the presence and expression of estrogen receptor, progesterone receptor, and HER2NEU proteins in breast cancer tissue. This helps in classifying the cancer subtype, predicting response to specific therapies like hormone or targeted treatments, and guiding personalized treatment plans for improved patient outcomes.
How to Prepare
- Obtain a doctor's prescription
- Use proper tissue preservation in formalin
- Label the sample correctly
- Transport to lab within stability period
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"IHC testing for ER, PR, and HER2NEU is crucial for personalizing breast cancer treatment plans, helping to determine the most effective therapies such as hormone or targeted treatments."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue sample
- Improper fixation or preservation
- Missing patient information or prescription
Understanding Your Results
ER/PR Positive
Likely to respond to hormone therapy such as tamoxifen or aromatase inhibitors.
ER/PR Negative
Unlikely to benefit from hormone therapy; other treatments considered.
HER2NEU Positive
May benefit from targeted therapy like trastuzumab (Herceptin).
HER2NEU Negative
Targeted HER2 therapy not indicated; focus on other treatment options.
All Negative
Triple-negative breast cancer; may require chemotherapy or other approaches.
Consult your oncologist immediately after receiving results to discuss treatment options. If symptoms persist or worsen, seek medical attention.
Limitations
- ⚠May not detect all protein expression levels
- ⚠Results can be influenced by tumor heterogeneity
- ⚠Requires expert interpretation
- ⚠Not a standalone diagnostic tool; used with other tests
Risks & Considerations
- ●Minimal risks from biopsy: bleeding, infection, or discomfort at collection site
- ●No risks from the IHC test itself
Interfering Factors
- ●Poor tissue fixation quality
- ●Antibody sensitivity and specificity
- ●Tissue processing artifacts
- ●Subjective interpretation by pathologist
Compare With Similar Tests
| Test | IHC ER-PR,HER2NEU | ||||
|---|---|---|---|---|---|
| Comparison | IHC ER-PR,HER2NEU | Imaging test for detection; IHC provides molecular details. | Confirmatory test for HER2 status if IHC is equivocal. | Measures proliferation rate; complements IHC for prognosis. | Sample collection method; IHC analyzes the tissue. |
Frequently Asked Questions
What is IHC ER-PR, HER2NEU testing?
Why is this test important for breast cancer?
How is the sample collected for this test?
What does a positive ER or PR result mean?
What does a positive HER2NEU result mean?
How long does it take to get the results?
Is fasting required for this test?
What is the cost of IHC ER-PR, HER2NEU testing in India?
Can this test be done at home?
What are the risks associated with the biopsy?
How accurate is IHC testing?
What should I do if my results are abnormal?
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