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IL12RB2 Gene Atypical Mycobacterial infection, IL12RB2 related NGS Genetic Test

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IL12RB2 Gene Atypical Mycobacterial infection, IL12RB2 related NGS Genetic Test

Short Name: IL12RB2 NGS Genetic Test

Also known as: IL12RB2 Genetic Test, Atypical Mycobacterial Infection NGS Test, IL12RB2 Mutation Analysis

IL12RB2 Gene Atypical Mycobacterial infection, IL12RB2 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt at the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the IL12RB2 gene that may increase susceptibility to atypical mycobacterial infections, facilitating early diagnosis and targeted treatment.

Test Code
2369
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt at the laboratory.
Fasting Required
No
Method
NGS (Next Generation Sequencing)
Step 1

Sample Collection

Genetic counseling session recommended. Provide detailed clinical history and family pedigree chart.

Method: Venipuncture or finger prick for FTA Card

Step 2

Laboratory Analysis

Standard blood draw via venipuncture or finger prick for FTA card, performed by a trained phlebotomist.

Step 3

Report Delivery

Sample sent to lab for processing; results available in 3-4 weeks with online access.

Timeline: 3 to 4 weeks from sample receipt at the laboratory.

Patient Instructions

1
Before the Test:Genetic counseling and informed consent are required. Provide medical history and family details.
2
During the Test:Sample collection as per instructions; analysis performed using NGS technology in a certified lab.
3
After the Test:Receive report via online portal; follow up with genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To identify mutations in the IL12RB2 gene that may increase susceptibility to atypical mycobacterial infections, facilitating early diagnosis and targeted treatment.

How to Prepare

  • Use sterile EDTA tubes or FTA cards
  • Label samples with patient details correctly
  • Transport FTA cards at room temperature
  • For blood samples, refrigerate at 2-8°C if not processed immediately

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for IL12RB2 can aid in early diagnosis and management of atypical mycobacterial infections, particularly in patients with recurrent infections or family history."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL for blood
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or finger prick for FTA Card

Sample Stability

Blood in EDTA
FTA Card
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the IL12RB2 gene, which may correlate with increased risk for atypical mycobacterial infections.
📊

Negative

No pathogenic variants detected; genetic risk for atypical mycobacterial infections is low. Clinical evaluation still recommended if symptomatic.

📊

Positive

Pathogenic variant detected; increased genetic risk for atypical mycobacterial infections. Genetic counseling and clinical management advised.

⚠️ When to Consult a Doctor:

If experiencing symptoms of atypical mycobacterial infection, have a family history of IL12RB2 mutations, or receive positive test results, consult an immunologist or geneticist for guidance.

Limitations

  • ⚠May not detect all rare or novel mutations due to sequencing limitations
  • ⚠Results require clinical correlation and genetic counseling for interpretation
  • ⚠Does not rule out other causes of infection

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact from genetic results, mitigated by counseling

Interfering Factors

  • ●DNA degradation in sample
  • ●Sample contamination
  • ●Incorrect sample type or handling

Compare With Similar Tests

TestIL12RB2 Gene Atypical Mycobacterial infection, IL12RB2 related NGS Genetic Test
ComparisonIL12RB2 Gene Atypical Mycobacterial infection, IL12RB2 related NGS Genetic Test

Frequently Asked Questions

What is the IL12RB2 gene?
The IL12RB2 gene provides instructions for making a protein involved in the immune response, and mutations can increase susceptibility to infections.
What are atypical mycobacterial infections?
These are infections caused by mycobacteria other than tuberculosis, often affecting immunocompromised individuals.
How does IL12RB2 mutation affect immunity?
Mutations can weaken the immune system's ability to fight mycobacteria, leading to recurrent infections.
Who should consider this genetic test?
Individuals with recurrent infections, family history of IL12RB2 mutations, or symptoms of immunodeficiency.
What is the cost of the IL12RB2 NGS genetic test?
The test costs INR 20000.0, including home collection and genetic counseling in India.
How is the test performed?
Using Next Generation Sequencing (NGS) to analyze the entire IL12RB2 gene for mutations.
What samples are required?
Blood, extracted DNA, or a blood drop on an FTA card.
Is home collection available?
Yes, free home sample collection is offered across India for online bookings.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample receipt.
What do the results mean?
Results indicate if pathogenic mutations are present, which may increase infection risk, requiring clinical correlation.
Is genetic counseling provided?
Yes, a genetic counseling session is included to interpret results and discuss implications.
Are there any risks associated with the test?
Risks are minimal, mainly related to blood draw, with psychological support available through counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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