Immunoglobulin IgD Serum Test
Short Name: IgD Serum Test
Also known as: IgD Blood Test, Serum IgD Level Test, Immunoglobulin D Test, IgD Quantitative Test, IgD Nephelometry Test
Immunoglobulin IgD Serum Test test available at DNA Labs India for ₹15,000. Uses Nephelometry on Serum samples. Results in Sample should reach the laboratory by the 7th of the month. Reports are typically available within 2-3 weeks after sample receipt. Digital reports will be delivered via online portal, email, and WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Immunoglobulin IgD Serum Test is to quantitatively measure the level of immunoglobulin D in the blood serum. This test helps clinicians diagnose and monitor conditions associated with abnormal IgD levels, including Hyper-IgD Syndrome (HIDS), multiple myeloma, and certain primary immunodeficiency disorders. It is also used to evaluate patients presenting with recurrent fever episodes, unexplained lymphadenopathy, or elevated total serum proteins when other immunoglobulin classes appear normal. The test aids in differential diagnosis and helps guide treatment decisions in complex immunological cases.
- Test Code
- 874
- CPT Code
- 82784
- ICD Code
- D89.89
- Price
- ₹15,000
- Sample Type
- Serum
- Result Time
- Sample should reach the laboratory by the 7th of the month. Reports are typically available within 2-3 weeks after sample receipt. Digital reports will be delivered via online portal, email, and WhatsApp.
- Fasting Required
- No
- Method
- Nephelometry
Sample Collection
No specific fasting is required for the Immunoglobulin IgD Serum Test. However, a duly filled Test Send Out Consent Form (Form 35) is mandatory before sample collection. Inform your physician about any medications, recent vaccinations, or ongoing infections prior to the test.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of venous blood from a vein in your arm using standard venipuncture technique. The blood will be drawn into a Serum Separator Tube (SST). The process typically takes less than 5 minutes and involves minimal discomfort.
Report Delivery
Apply gentle pressure on the puncture site with cotton or a bandage for 3-5 minutes. Avoid heavy lifting with the collection arm for a few hours. Mild bruising at the site is normal and resolves on its own. The sample will be processed and shipped refrigerated or frozen to the testing laboratory.
Timeline: Sample should reach the laboratory by the 7th of the month. Reports are typically available within 2-3 weeks after sample receipt. Digital reports will be delivered via online portal, email, and WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Immunoglobulin IgD Serum Test is to quantitatively measure the level of immunoglobulin D in the blood serum. This test helps clinicians diagnose and monitor conditions associated with abnormal IgD levels, including Hyper-IgD Syndrome (HIDS), multiple myeloma, and certain primary immunodeficiency disorders. It is also used to evaluate patients presenting with recurrent fever episodes, unexplained lymphadenopathy, or elevated total serum proteins when other immunoglobulin classes appear normal. The test aids in differential diagnosis and helps guide treatment decisions in complex immunological cases.
How to Prepare
- Duly filled Test Send Out Consent Form (Form 35) is mandatory before sample collection
- No fasting is required unless specifically instructed by your physician
- Inform the phlebotomist about any medications, supplements, or recent vaccinations
- Wear loose-fitting sleeves to facilitate easy blood draw from the arm
- Stay hydrated before sample collection to ensure adequate vein access
- Report any history of bleeding disorders or use of blood-thinning medications
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The Immunoglobulin IgD Serum Test is an important but specialized investigation. IgD constitutes less than 1% of total serum immunoglobulins, and its clinical significance is still being studied. This test is most valuable in evaluating suspected Hyper-IgD Syndrome (HIDS), certain cases of multiple myeloma, and selected immunodeficiency disorders. It is not a routine screening test and should be ordered only when clinically indicated based on the patient's symptoms, medical history, and other laboratory findings. Patients with recurrent fevers, unexplained lymphadenopathy, or elevated total serum proteins may benefit from this evaluation. Always discuss your results with your treating immunologist for proper clinical correlation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected without the mandatory Test Send Out Consent Form (Form 35)
- Hemolyzed, lipemic, or grossly contaminated serum samples
- Samples received at room temperature beyond 8 hours of collection
- Insufficient sample volume (less than 1 mL serum)
- Samples with mismatched patient identification or labeling errors
Understanding Your Results
IgD levels within the normal reference range suggest no significant IgD-related pathology. Clinical correlation is still advised if symptoms persist.
Range: 0–100 IU/mL
Markedly elevated IgD is characteristic of Hyper-IgD Syndrome (HIDS), a rare autosomal recessive auto-inflammatory disorder caused by mutations in the mevalonate kinase gene. Patients typically present with recurrent fever episodes, abdominal pain, joint pain, skin rashes, and swollen lymph nodes.
Range: Significantly above normal (>100 IU/mL, often >1000 IU/mL)
Very high serum IgD concentrations are found in a subset of multiple myeloma patients (IgD myeloma accounts for approximately 1-2% of all myeloma cases). Additional tests such as serum protein electrophoresis, urine Bence Jones proteins, and bone marrow biopsy are required for confirmation.
Range: Very high levels, often >1000 IU/mL
Mild elevations may be seen in chronic infections, autoimmune diseases, liver disease, and certain inflammatory conditions. Clinical correlation and repeat testing may be needed to determine significance.
Range: Slightly above normal range
Consult your doctor or immunologist if your IgD levels are elevated, especially if you experience recurrent unexplained fevers, joint pain, abdominal pain, skin rashes, or swollen lymph nodes. If IgD levels are very high, your physician may recommend additional investigations including serum protein electrophoresis, urine analysis for Bence Jones proteins, bone marrow examination, or genetic testing for mevalonate kinase mutations to establish a definitive diagnosis. Early consultation with a specialist is important for timely diagnosis and management of conditions like HIDS or IgD multiple myeloma.
Limitations
- ⚠IgD levels are normally very low in serum, and results must be interpreted in clinical context
- ⚠This test alone is not diagnostic and must be correlated with clinical findings and other laboratory investigations
- ⚠Reference ranges may vary between laboratories and methods used
- ⚠The test does not distinguish between monoclonal and polyclonal IgD elevation; further testing such as serum protein electrophoresis may be needed
- ⚠Functional significance of mildly elevated IgD levels remains under research and may not always indicate disease
Risks & Considerations
- ●Minor bruising or hematoma at the blood collection site
- ●Brief pain or discomfort during venipuncture
- ●Rarely, dizziness or lightheadedness during or after blood draw
- ●Very rare risk of infection at the puncture site
- ●Extremely rare risk of excessive bleeding in individuals with bleeding disorders
Interfering Factors
- ●Recent immunizations or vaccinations may transiently affect immunoglobulin levels
- ●Hemolyzed or lipemic samples may interfere with nephelometry results
- ●Concurrent use of immunosuppressive or immunomodulatory medications may alter IgD levels
- ●Recent blood transfusions may affect serum immunoglobulin concentrations
- ●Timing of sample collection relative to active infection or inflammatory flare may influence results
Compare With Similar Tests
| Test | Immunoglobulin IgD Serum Test | Immunoglobulin IgA Serum Test | Immunoglobulin IgG Serum Test | Immunoglobulin IgM Serum Test | Immunoglobulin IgE Serum Test | Serum Protein Electrophoresis (SPEP) |
|---|---|---|---|---|---|---|
| Comparison | Immunoglobulin IgD Serum Test |
Frequently Asked Questions
What is the Immunoglobulin IgD Serum Test?
Why is the Immunoglobulin IgD Serum Test ordered?
What is the cost of the Immunoglobulin IgD Serum Test at DNA Labs India?
Is fasting required before the IgD Serum Test?
What sample is needed for the IgD Serum Test?
What is Hyper-IgD Syndrome (HIDS)?
What do elevated IgD levels indicate?
What does a normal IgD level mean?
How long does it take to get IgD Serum Test results?
Is the Immunoglobulin IgD Serum Test available with home sample collection?
What is the difference between IgD and other immunoglobulins?
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