Immunoglobulin IgG Serum Test
Short Name: IgG Serum Test
Also known as: IgG Test, Immunoglobulin G Test, Serum IgG Test, IgG Antibody Test, Quantitative IgG Test
Immunoglobulin IgG Serum Test test available at DNA Labs India for ₹410. Uses Immunoturbidimetry on Serum samples. Results in Results are typically available within the same day to 24 hours after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Immunoglobulin IgG Serum Test is to measure the level of IgG antibodies in the blood to help diagnose, screen, and monitor conditions related to the immune system. This includes detection of immunodeficiency disorders where IgG levels are abnormally low, identification of autoimmune diseases and chronic infections where IgG may be elevated, and monitoring of monoclonal gammopathies such as multiple myeloma where a single clone of plasma cells produces excessive amounts of IgG. The assay is also useful for evaluating patients with recurrent infections, unexplained fatigue, or clinical suspicion of a plasma cell neoplasm. Serial measurement of IgG levels assists clinicians in assessing treatment response, disease progression, and overall immune competence.
- Test Code
- 878
- CPT Code
- 82784
- ICD Code
- D80-D89
- Price
- ₹410
- Sample Type
- Serum
- Result Time
- Results are typically available within the same day to 24 hours after sample collection.
- Fasting Required
- No
- Method
- Immunoturbidimetry
Sample Collection
No special preparation or fasting is required. Inform your healthcare provider about any medications, recent vaccinations, or immunoglobulin therapy before the test.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of blood from a vein in your arm using a needle and Serum Separator Tube (SST). The procedure typically takes less than 5 minutes.
Report Delivery
Apply gentle pressure on the puncture site with cotton or gauze for a few minutes to stop bleeding. A small bruise may appear, which usually resolves within a few days. You can resume normal activities immediately after sample collection.
Timeline: Results are typically available within the same day to 24 hours after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Immunoglobulin IgG Serum Test is to measure the level of IgG antibodies in the blood to help diagnose, screen, and monitor conditions related to the immune system. This includes detection of immunodeficiency disorders where IgG levels are abnormally low, identification of autoimmune diseases and chronic infections where IgG may be elevated, and monitoring of monoclonal gammopathies such as multiple myeloma where a single clone of plasma cells produces excessive amounts of IgG. The assay is also useful for evaluating patients with recurrent infections, unexplained fatigue, or clinical suspicion of a plasma cell neoplasm. Serial measurement of IgG levels assists clinicians in assessing treatment response, disease progression, and overall immune competence.
How to Prepare
- No fasting is required before this test
- Stay well hydrated before sample collection
- Inform the phlebotomist if you have a history of fainting during blood draws
- Wear a short-sleeved or loose-fitting shirt for easy access to the arm
- Carry a valid photo ID and the doctor's prescription or test requisition form
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Immunoglobulin IgG is the most abundant antibody in serum, constituting approximately 80% of total immunoglobulins. This test is indispensable in clinical oncology for detecting and monitoring monoclonal gammopathies such as multiple myeloma, Waldenström macroglobulinemia, and other plasma cell dyscrasias. A monoclonal spike on serum protein electrophoresis combined with elevated IgG levels warrants further investigation including serum free light chain assay and bone marrow biopsy. In immunodeficiency workups, persistently low IgG levels may indicate primary immunodeficiency or secondary causes such as nephrotic syndrome, protein-losing enteropathy, or immunosuppressive therapy. Serial monitoring of IgG levels helps clinicians assess treatment response and disease progression. I recommend this test for patients presenting with recurrent infections, unexplained fatigue, bone pain, or laboratory findings suggestive of a plasma cell neoplasm. Always interpret IgG levels in conjunction with IgA, IgM, serum protein electrophoresis, and clinical presentation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received in a non-SST tube without prior arrangement
- Hemolyzed, lipemic, or grossly contaminated sample
- Sample volume insufficient for testing (less than 1 mL serum)
- Sample not stored or transported under recommended conditions
- Unlabeled or mislabeled specimen
Understanding Your Results
Normal IgG levels suggest adequate immune function. No evidence of immunodeficiency, active chronic infection, or monoclonal gammopathy based on this parameter alone.
Low IgG levels may indicate primary immunodeficiency (e.g., common variable immunodeficiency, X-linked agammaglobulinemia), secondary immunodeficiency due to nephrotic syndrome, protein-losing enteropathy, immunosuppressive therapy, or malignancies affecting B-cell function.
Elevated IgG levels may be seen in chronic infections (e.g., hepatitis, tuberculosis), autoimmune diseases (e.g., SLE, rheumatoid arthritis), liver disease, or monoclonal gammopathies such as multiple myeloma. Polyclonal elevation suggests a broad immune response, while monoclonal elevation is characteristic of plasma cell neoplasms.
Consult your healthcare provider if your IgG levels are outside the normal reference range. Low IgG levels accompanied by recurrent infections, persistent fatigue, or poor response to antibiotics require prompt medical evaluation. Elevated IgG levels, especially with bone pain, unexplained weight loss, anemia, or kidney dysfunction, warrant further investigation to rule out conditions such as multiple myeloma or autoimmune disease. Your doctor may recommend additional tests including serum protein electrophoresis, immunofixation, serum free light chain assay, or a bone marrow biopsy for definitive diagnosis.
Limitations
- ⚠This test measures total IgG and does not distinguish between IgG subclasses (IgG1, IgG2, IgG3, IgG4); subclass-specific testing is required if a subclass deficiency is suspected
- ⚠Elevated IgG levels are non-specific and do not point to a single diagnosis; additional tests such as serum protein electrophoresis (SPEP), immunofixation, or serum free light chain assay are often required for definitive diagnosis
- ⚠Results should always be interpreted in the context of the patient's clinical history, symptoms, and other laboratory findings
- ⚠Monoclonal IgG elevation may be masked in cases of immunosuppression
Risks & Considerations
- ●Mild pain or discomfort at the needle insertion site
- ●Minor bruising or swelling at the puncture site
- ●Slight risk of infection at the venipuncture site (extremely rare)
- ●Lightheadedness or dizziness during or after blood draw in sensitive individuals
Interfering Factors
- ●Recent immunization or vaccination may transiently elevate IgG levels
- ●Immunosuppressive medications such as corticosteroids or chemotherapy agents may lower IgG levels
- ●Intravenous immunoglobulin (IVIG) therapy will significantly affect results
- ●Severe hemolysis or lipemia in the sample may interfere with immunoturbidimetric measurement
- ●Recent blood transfusion may alter immunoglobulin levels
Compare With Similar Tests
| Test | Immunoglobulin IgG Serum Test | Immunoglobulin IgA Serum Test | Immunoglobulin IgM Serum Test | Immunoglobulin IgE Serum Test | Serum Protein Electrophoresis (SPEP) |
|---|---|---|---|---|---|
| Comparison | Immunoglobulin IgG Serum Test |
Frequently Asked Questions
What is the Immunoglobulin IgG Serum Test?
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Is fasting required for the Immunoglobulin IgG Serum Test?
What is the normal range for IgG levels?
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