Immunoglobulin IgM Serum Test
Short Name: IgM Serum Test
Also known as: IgM Test, Serum IgM Test, Immunoglobulin M Blood Test, IgM Antibody Test, Quantitative IgM Test
Immunoglobulin IgM Serum Test test available at DNA Labs India for ₹503. Uses Immunoturbidimetry on Serum samples. Results in Results are typically available within 24 hours of sample collection.. Free home collection in 300+ cities across India.
Overview
The Immunoglobulin IgM Serum Test is used to evaluate the body's immune function by measuring the level of IgM antibodies. It aids in diagnosing acute infections, primary immunodeficiency disorders such as selective IgM deficiency, and lymphoproliferative conditions like Waldenström's macroglobulinemia. The test is also used to monitor treatment response in patients with monoclonal gammopathies and to assess immune status in patients with recurrent or chronic infections.
- Test Code
- 880
- CPT Code
- 82784
- ICD Code
- D80.4
- Price
- ₹503
- Sample Type
- Serum
- Result Time
- Results are typically available within 24 hours of sample collection.
- Fasting Required
- No
- Method
- Immunoturbidimetry
Sample Collection
No special preparation or fasting is required. Inform your doctor about any medications, recent vaccinations, or supplements you are taking.
Method: Venipuncture
Laboratory Analysis
A standard venipuncture will be performed. A blood sample of approximately 2 mL will be drawn into a Serum Separator Tube (SST).
Report Delivery
Apply pressure to the puncture site with sterile cotton for a few minutes. Mild bruising may occur and typically resolves within a few days.
Timeline: Results are typically available within 24 hours of sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The Immunoglobulin IgM Serum Test is used to evaluate the body's immune function by measuring the level of IgM antibodies. It aids in diagnosing acute infections, primary immunodeficiency disorders such as selective IgM deficiency, and lymphoproliferative conditions like Waldenström's macroglobulinemia. The test is also used to monitor treatment response in patients with monoclonal gammopathies and to assess immune status in patients with recurrent or chronic infections.
How to Prepare
- No fasting is required before sample collection
- Inform the phlebotomist of any medications or recent vaccinations
- Sample must be collected in an SST (Serum Separator Tube)
- Minimum 2 mL (1 mL min.) of serum is required
- Ship refrigerated or frozen if not processed immediately
Doctor's Notes
"Immunoglobulin M (IgM) is the first antibody produced by the immune system in response to a new infection. IgM constitutes approximately 5% of total immunoglobulins in serum. An elevation may be polyclonal, as seen in acute infections, or monoclonal, as seen in Waldenström's macroglobulinemia (Monoclonal Gammopathy). Low IgM levels may indicate selective IgM deficiency or a broader immunodeficiency. This assay, performed using immunoturbidimetry, is a reliable and quantitative method for detecting and monitoring monoclonal gammopathies, primary immunodeficiencies, and acute-phase immune responses. I recommend this test for patients presenting with recurrent infections, chronic diarrhoea, or suspected immune dysfunction. Always correlate IgM results with IgG, IgA levels, and clinical findings for a comprehensive immune assessment."
Test Parameters & Specifications
Sample Stability
- Haemolysed, lipaemic, or icteric samples
- Samples collected in incorrect tube type
- Samples exceeding stability time limits
- Unlabelled or improperly labelled samples
Understanding Your Results
Low IgM levels may indicate selective IgM deficiency, protein-losing enteropathy, nephrotic syndrome, immunosuppressive therapy, or a compromised immune system. Patients with low IgM are at increased risk of recurrent infections.
Status: Low
Range: Below 40 mg/dL
IgM levels within the reference range generally indicate normal immune function. Results should be interpreted alongside clinical presentation and other immunoglobulin levels.
Status: Normal
Range: 40–230 mg/dL
Elevated IgM levels may indicate acute infection (viral or bacterial), chronic liver disease, autoimmune disorders, lymphoproliferative disorders such as Waldenström's macroglobulinemia, or a polyclonal immune activation. Further evaluation with serum protein electrophoresis and additional immunoglobulin testing is recommended.
Status: High
Range: Above 230 mg/dL
Consult a healthcare provider if your IgM levels are outside the reference range, or if you experience frequent infections, chronic diarrhoea, unexplained fatigue, or signs of autoimmune disease. A physician specializing in immunology or allergy/immunology can provide a comprehensive evaluation and guide appropriate treatment.
Limitations
- ⚠IgM levels alone do not confirm a specific diagnosis and must be interpreted alongside clinical symptoms and other laboratory tests
- ⚠The test measures total IgM and cannot distinguish between polyclonal and monoclonal elevations without additional testing such as serum protein electrophoresis
- ⚠Reference ranges may vary by age, sex, and laboratory methodology
- ⚠Results should always be correlated with IgG, IgA, CBC, and clinical findings
Risks & Considerations
- ●Minor bruising or swelling at the puncture site
- ●Slight pain or discomfort during the needle insertion
- ●Very rare risk of fainting or dizziness
- ●Extremely rare risk of infection at the puncture site
Interfering Factors
- ●Recent immunisations or vaccinations may transiently elevate IgM levels
- ●Hemolysed or lipaemic serum samples may affect assay accuracy
- ●Certain medications such as immunosuppressants may lower IgM levels
- ●Recent blood transfusions may alter immunoglobulin levels
Compare With Similar Tests
| Test | Immunoglobulin IgM Serum Test | ||||
|---|---|---|---|---|---|
| Comparison | Immunoglobulin IgM Serum Test |
Frequently Asked Questions
What is the Immunoglobulin IgM Serum Test?
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What is the cost of the IgM Serum Test at DNA Labs India?
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What does a high IgM level indicate?
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