Immunohistochemistry ATRX Test
Short Name: IHC ATRX Test
Also known as: ATRX IHC Test, ATRX Immunohistochemistry, ATRX Protein Expression Test
Immunohistochemistry ATRX Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports available within 5-7 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To detect loss of ATRX protein expression in tumor tissues, aiding in the diagnosis of ATR-X syndrome, subtyping of gliomas (e.g., diffuse gliomas), prediction of IDH mutations, and informing treatment strategies and prognosis.
- Test Code
- 963
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Reports available within 5-7 days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide complete clinical history, histopathology report, and site of biopsy to the healthcare provider.
Method: Tissue biopsy or surgical resection
Laboratory Analysis
Sample collection is performed via biopsy or surgical procedure by a qualified professional.
Report Delivery
Ensure sample is properly labeled and transported in appropriate medium at room temperature.
Timeline: Reports available within 5-7 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To detect loss of ATRX protein expression in tumor tissues, aiding in the diagnosis of ATR-X syndrome, subtyping of gliomas (e.g., diffuse gliomas), prediction of IDH mutations, and informing treatment strategies and prognosis.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block.
- Ship at room temperature.
- Include a copy of the histopathology report, site of biopsy, and clinical history.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The IHC ATRX test is crucial for precise diagnosis and subtyping of gliomas, aiding in tailored treatment plans and prognostic assessment."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate sample quantity or quality.
- Missing clinical information or histopathology report.
- Improper fixation or container.
Understanding Your Results
Positive ATRX expression
Normal protein present; less likely ATR-X syndrome or specific glioma subtypes.
Negative ATRX expression (loss)
Suggests ATRX mutation; associated with ATR-X syndrome or IDH-mutant gliomas; may indicate better prognosis in certain tumors.
If symptoms like developmental delays, intellectual disability, or neurological issues arise, or if diagnosed with glioma, consult an oncologist or geneticist for test interpretation and management.
Limitations
- ⚠Cannot detect all types of ATRX mutations; may require genetic confirmation.
- ⚠Subjective interpretation; dependent on pathologist expertise.
- ⚠Limited to tissue samples; not applicable for blood or fluid-based testing.
- ⚠May not differentiate between benign and malignant conditions alone.
Risks & Considerations
- ●Minimal risks from biopsy procedure, such as infection or bleeding, if applicable.
Interfering Factors
- ●Poor tissue fixation or preservation.
- ●Inadequate sample size or quality.
- ●Use of incorrect antibody or protocol.
- ●Technical errors in staining process.
Compare With Similar Tests
| Test | Immunohistochemistry ATRX Test | Genetic Testing for ATRX | Immunohistochemistry IDH1 Test | MRI Brain Scan |
|---|---|---|---|---|
| Comparison | Immunohistochemistry ATRX Test | Direct DNA sequencing for ATRX mutations; more comprehensive but costlier than IHC. | Detects IDH1 mutations; often used alongside ATRX IHC for glioma subtyping. | Imaging test for structural abnormalities; does not detect molecular changes like ATRX. |
Frequently Asked Questions
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