Immunohistochemistry BCL-6 Test
Short Name: BCL-6 IHC Test
Also known as: BCL-6 Immunohistochemistry, BCL-6 Protein Detection Test, IHC BCL-6 Test
Immunohistochemistry BCL-6 Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue samples. Results in Reports are typically available within 5-7 days after sample receipt, depending on sample type and complexity.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Immunohistochemistry BCL-6 Test is to identify the presence of BCL-6 protein in cancerous tissues, which helps in diagnosing specific types of lymphomas and leukemias. It assists in cancer subtyping, prognosis evaluation, and guiding treatment strategies, such as targeted therapies.
- Test Code
- 911
- Price
- ₹3,500
- Sample Type
- Tumor tissue
- Result Time
- Reports are typically available within 5-7 days after sample receipt, depending on sample type and complexity.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Ensure a histopathology report, site of biopsy, and clinical history are available. No special patient preparation is required for the test itself.
Method: Biopsy or surgical excision
Laboratory Analysis
Tumor tissue is collected via biopsy or surgical excision by a healthcare professional. The sample is then placed in 10% Formal-saline or Formalin fixed paraffin embedded block for preservation.
Report Delivery
Ship the sample at room temperature to the laboratory. Provide all necessary documentation for accurate analysis.
Timeline: Reports are typically available within 5-7 days after sample receipt, depending on sample type and complexity.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Immunohistochemistry BCL-6 Test is to identify the presence of BCL-6 protein in cancerous tissues, which helps in diagnosing specific types of lymphomas and leukemias. It assists in cancer subtyping, prognosis evaluation, and guiding treatment strategies, such as targeted therapies.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block.
- Ship at room temperature.
- Include a copy of the Histopathology report, Site of biopsy, and Clinical history.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The IHC BCL-6 Test is crucial for identifying specific subtypes of lymphomas and leukemias, aiding in targeted treatment planning and prognosis assessment."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improper fixation or container
- Missing documentation (histopathology report, clinical history)
- Contaminated or degraded sample
Understanding Your Results
Positive for BCL-6
BCL-6 protein is detected, supporting diagnosis of cancers like lymphomas (e.g., Follicular, Diffuse Large B-cell) or leukemias. May indicate aggressive disease subtype and guide treatment options.
Action: Consult an oncologist for further evaluation and treatment planning.
Negative for BCL-6
BCL-6 protein is not detected, which may help rule out certain cancer types but does not exclude other malignancies.
Action: Consider additional diagnostic tests based on clinical suspicion and pathology report.
Consult a doctor if you experience symptoms such as enlarged lymph nodes, unexplained weight loss, fever, night sweats, or fatigue, especially if you have a history of cancer or abnormal biopsy results.
Limitations
- ⚠Not a standalone diagnostic test; requires correlation with histopathology and clinical data
- ⚠May not detect low levels of protein expression
- ⚠Results can vary based on tissue processing and laboratory expertise
Risks & Considerations
- ●Minimal risks associated with biopsy collection, such as bleeding or infection
- ●No direct risks from the IHC test itself, as it is a laboratory procedure
Interfering Factors
- ●Improper tissue fixation
- ●Sample degradation during transport
- ●Inadequate biopsy size
- ●Use of incorrect antibodies or staining protocols
Compare With Similar Tests
| Test | Immunohistochemistry BCL-6 Test | Immunohistochemistry CD20 Test | Flow Cytometry for Lymphoma | FISH for Genetic Abnormalities | PCR for BCL-6 Gene Rearrangement |
|---|---|---|---|---|---|
| Comparison | Immunohistochemistry BCL-6 Test | Both tests use immunohistochemistry for lymphoma diagnosis, but CD20 targets B-cell markers, while BCL-6 is specific for certain subtypes. | Flow cytometry analyzes cell populations in fluid samples, whereas IHC BCL-6 uses fixed tissue for protein detection. | FISH detects genetic changes, while IHC BCL-6 focuses on protein expression, providing complementary information. | PCR analyzes genetic rearrangements, whereas IHC BCL-6 detects protein presence; both can be used for lymphoma subtyping. |
Frequently Asked Questions
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