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Immunohistochemistry Caldesmon Test

DNA Labs India | ISO 9001:2015 Certified

Immunohistochemistry Caldesmon Test

Short Name: IHC Caldesmon Test

Also known as: Caldesmon IHC, Smooth Muscle Caldesmon Test

Immunohistochemistry Caldesmon Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports typically available within 5-7 days after sample receipt.. Free home collection in 300+ cities across India.

ImmunohistochemistryNot specified🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect caldesmon expression in tissues for diagnosing smooth muscle-related tumors and conditions, aiding in clinical decision-making.

Test Code
915
Price
₹3,500
Sample Type
Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
Result Time
Reports typically available within 5-7 days after sample receipt.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Ensure biopsy or surgical procedure is performed correctly. Provide complete clinical history and histopathology report.

Method: Biopsy or Surgery

Step 2

Laboratory Analysis

Tissue sample is collected and immediately fixed in 10% formal-saline or formalin to preserve integrity.

Step 3

Report Delivery

Fixed sample is sent to the laboratory for processing, staining, and microscopic examination.

Timeline: Reports typically available within 5-7 days after sample receipt.

Patient Instructions

1
Before the Test:No specific preparation is required from the patient, but ensure tissue sample is properly collected and fixed.
2
During the Test:Laboratory processing involves tissue sectioning, antibody staining, and microscopic examination by a pathologist.
3
After the Test:Results are reviewed by a pathologist and reported to the referring physician for clinical interpretation.

About This Test

Who Should Get This Test

To detect caldesmon expression in tissues for diagnosing smooth muscle-related tumors and conditions, aiding in clinical decision-making.

How to Prepare

  • Submit tumor tissue in appropriate fixative
  • Include a copy of the histopathology report
  • Provide site of biopsy and detailed clinical history

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is essential for identifying smooth muscle differentiation in tumors, aiding in accurate diagnosis and treatment planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
Sample VolumeAdequate for histopathology
Container10% Formal-saline or Formalin fixed paraffin embedded block
Collection MethodBiopsy or Surgery

Sample Stability

Stable at room temperature when properly fixed
Store in formalin for up to 72 hours before processing
Sample Rejection Criteria:
  • Inadequate tissue sample size
  • Improper fixation or preservation
  • Missing clinical information or histopathology report

Understanding Your Results

Results indicate the presence or absence of caldesmon expression in the tissue sample, which is interpreted by pathologists.
Positive staining suggests smooth muscle differentiation in the tumor
Negative staining may indicate non-smooth muscle origin or technical issues
Results should be correlated with clinical findings and other tests
Quantitative assessment may vary based on staining intensity
⚠️ When to Consult a Doctor:

Consult an oncologist or specialist if experiencing symptoms like abdominal pain, abnormal uterine bleeding, palpable masses, or if recommended based on initial biopsy findings.

Limitations

  • ⚠Not a standalone diagnostic tool; must correlate with clinical and histopathological findings
  • ⚠May not detect all smooth muscle tumors if antigen is lost
  • ⚠Subjective interpretation by pathologists
  • ⚠Cannot determine malignancy grade alone

Risks & Considerations

  • ●Minimal risks associated with biopsy or surgical procedure, such as infection or bleeding
  • ●No direct risks from the test itself as it is performed on excised tissue

Interfering Factors

  • ●Improper tissue fixation
  • ●Poor sample quality or inadequate tissue size
  • ●Technical errors in staining process
  • ●Use of incorrect antibodies

Compare With Similar Tests

TestImmunohistochemistry Caldesmon Test
ComparisonImmunohistochemistry Caldesmon Test

Frequently Asked Questions

What is the Immunohistochemistry Caldesmon Test?
It is a diagnostic test that detects caldesmon protein in tissues to identify smooth muscle differentiation in tumors.
What conditions does this test diagnose?
It helps diagnose gastrointestinal stromal tumors (GISTs), leiomyomas, leiomyosarcomas, fibromatosis, and other smooth muscle tumors.
How is the test performed?
Tissue samples from biopsy or surgery are stained with antibodies and examined under a microscope by a pathologist.
What is the cost of the test in India?
The cost is approximately INR 3500, with free home collection available in many cities.
Is home sample collection available?
Yes, DNA Labs India offers free home collection for online bookings across India.
How long does it take to get results?
Reports are typically available within 5-7 days after sample receipt.
What does a positive result mean?
A positive result indicates the presence of caldesmon, suggesting smooth muscle origin in the tumor.
What should I do before the test?
Ensure your doctor provides the biopsy tissue, histopathology report, and clinical history.
Are there any risks associated with the test?
The test itself has no risks, but biopsy procedures may have minor risks like infection.
Who should consider taking this test?
Patients with suspected smooth muscle tumors or symptoms like abdominal pain and abnormal bleeding, as recommended by their doctor.
How accurate is the Immunohistochemistry Caldesmon Test?
It is highly accurate for detecting smooth muscle differentiation when performed correctly, but results should be correlated with clinical data.
Can this test be done on blood samples?
No, it requires tissue samples from biopsy or surgery, not blood.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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