Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test
Short Name: CA-9 IHC Test
Also known as: CA-9 IHC Test, Carbonic Anhydrase 9 Immunohistochemistry Test
Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Report available in 5-7 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test is to detect overexpression of CA-9 in tumor tissues, which is associated with tumor hypoxia and aggressiveness in cancers such as renal cell carcinoma. It helps in confirming diagnosis, assessing prognosis, and guiding treatment plans, including targeted therapies.
- Test Code
- 897
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Report available in 5-7 days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Method: Tissue biopsy
Laboratory Analysis
Sample collected via tissue biopsy from the affected area.
Report Delivery
Store sample at room temperature and transport as per instructions to the lab.
Timeline: Report available in 5-7 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test is to detect overexpression of CA-9 in tumor tissues, which is associated with tumor hypoxia and aggressiveness in cancers such as renal cell carcinoma. It helps in confirming diagnosis, assessing prognosis, and guiding treatment plans, including targeted therapies.
How to Prepare
- Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block.
- Ship at room temperature.
- Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"CA-9 IHC test is vital for identifying tumor hypoxia in cancers like renal cell carcinoma, aiding in targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improperly fixed or stored tissue
- Missing clinical history or biopsy details
Understanding Your Results
Positive
Indicates overexpression of CA-9, commonly seen in clear cell renal cell carcinoma and other cancers, suggesting tumor hypoxia and potential aggressiveness.
Action: Consult an oncologist for further management and targeted therapy options.
Negative
No significant CA-9 expression detected, which may indicate lower hypoxia or different cancer subtype.
Action: Consider other diagnostic tests and clinical evaluation.
If the CA-9 test is positive, or if you have symptoms suggestive of cancer such as unexplained weight loss, fatigue, or lumps, consult an oncologist immediately.
Limitations
- ⚠Not a standalone diagnostic test; clinical correlation is necessary.
- ⚠Results may vary based on tissue quality and fixation.
- ⚠Limited to specific cancer types where CA-9 is relevant.
Risks & Considerations
- ●Infection at biopsy site
- ●Bleeding or hematoma
- ●Pain or discomfort during biopsy
- ●Rare allergic reaction to local anesthesia
Interfering Factors
- ●Inadequate tissue fixation
- ●Improper storage conditions
- ●Contamination during processing
Compare With Similar Tests
| Test | Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test | Biopsy with H&E Staining | CT Scan | PET Scan |
|---|---|---|---|---|
| Comparison | Immunohistochemistry Carbonic Anhydrase-9 (CA-9) Test | Standard histological examination for tissue structure, while CA-9 IHC provides specific protein expression data for targeted insights. | Imaging test for anatomical changes, whereas CA-9 IHC analyzes molecular markers at the cellular level. | Functional imaging for metabolic activity, complementing CA-9 IHC which focuses on protein expression. |
Frequently Asked Questions
What is the CA-9 IHC test?
Why is the CA-9 test performed?
What sample is required for the CA-9 test?
How much does the CA-9 test cost in India?
Is home collection available for the CA-9 test?
How long does it take to get CA-9 test results?
What does a positive CA-9 result mean?
What cancers are associated with CA-9 overexpression?
Are there any risks associated with the biopsy for CA-9 testing?
How should I prepare for the CA-9 test?
Can the CA-9 test be used for cancer screening?
Who should I consult if my CA-9 test is positive?
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