Immunohistochemistry CD7 Test
Short Name: IHC CD7
Also known as: CD7 Immunostain, CD7 IHC, CD7 Antibody Test, Immunohistochemistry CD7 Staining, CD7 Antigen Detection
Immunohistochemistry CD7 Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry (IHC), Monoclonal Antibody Staining, Peroxidase-Antiperoxidase Technique on Tumor Tissue (Formalin-fixed paraffin-embedded block or fresh tissue in 10% Formal-saline) samples. Results in Report: Block 5 days | Tissue Biopsy: 5 days | Tissue Large Complex: 7 days. Sample accepted daily by 6 PM.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The Immunohistochemistry CD7 Test is performed to detect the CD7 antigen on lymphoid tissue sections. It is primarily used to identify T-cell lymphomas and leukemias, differentiate T-cell neoplasms from reactive conditions, and confirm the diagnosis of Mycosis Fungoides and Cutaneous T-cell Lymphoma where loss of CD7 is a characteristic finding. This test aids pathologists and oncologists in accurate classification and staging of the disease.
- Test Code
- 986
- CPT Code
- 88342
- ICD Code
- C84.7
- Price
- ₹3,500
- Sample Type
- Tumor Tissue (Formalin-fixed paraffin-embedded block or fresh tissue in 10% Formal-saline)
- Result Time
- Report: Block 5 days | Tissue Biopsy: 5 days | Tissue Large Complex: 7 days. Sample accepted daily by 6 PM.
- Fasting Required
- No
- Method
- Immunohistochemistry (IHC), Monoclonal Antibody Staining, Peroxidase-Antiperoxidase Technique
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history. Ensure tissue is properly fixed in 10% Formal-saline or as a formalin-fixed paraffin-embedded (FFPE) block.
Method: Surgical biopsy, excisional biopsy, incisional biopsy, or core needle biopsy
Laboratory Analysis
Sample is collected via biopsy procedure (surgical, excisional, incisional, or core needle) performed by the treating physician or surgeon.
Report Delivery
Ensure the specimen is labeled correctly with patient details. Ship at room temperature. Provide complete clinical history and prior pathology reports for accurate interpretation.
Timeline: Report: Block 5 days | Tissue Biopsy: 5 days | Tissue Large Complex: 7 days. Sample accepted daily by 6 PM.
Patient Instructions
About This Test
Who Should Get This Test
The Immunohistochemistry CD7 Test is performed to detect the CD7 antigen on lymphoid tissue sections. It is primarily used to identify T-cell lymphomas and leukemias, differentiate T-cell neoplasms from reactive conditions, and confirm the diagnosis of Mycosis Fungoides and Cutaneous T-cell Lymphoma where loss of CD7 is a characteristic finding. This test aids pathologists and oncologists in accurate classification and staging of the disease.
How to Prepare
- Submit tumor tissue in 10% Formal-saline OR as a Formalin-Fixed Paraffin-Embedded (FFPE) block
- Ship the specimen at room temperature
- Provide a copy of the histopathology report
- Mention the exact site of biopsy on the requisition form
- Include relevant clinical history and suspected diagnosis
- Label the container clearly with patient name, date, and specimen details
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Immunohistochemistry CD7 is a valuable ancillary marker in the workup of T-cell lymphoproliferative disorders. Aberrant loss of CD7 expression is frequently observed in cutaneous T-cell lymphomas, including Mycosis Fungoides, and helps distinguish neoplastic from reactive T-cell populations. I routinely order this test alongside a panel of T-cell markers (CD2, CD3, CD4, CD5, CD8) to arrive at an accurate diagnosis and guide treatment planning. Patients presenting with persistent skin patches, plaques, or unexplained lymphadenopathy should be evaluated promptly with appropriate immunohistochemical studies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Specimen received without proper fixation or in dried condition
- Specimen without patient identification or requisition form
- Tissue with extensive necrosis or autolysis making interpretation unreliable
- Specimen received in expired or inappropriate fixative
- Absence of clinical history or biopsy site information
Understanding Your Results
Normal CD7 expression is seen on T cells and NK cells. Retained CD7 expression in a lymphoid infiltrate may suggest a reactive process or a T-cell neoplasm that has retained the marker. Correlation with morphology and other markers is essential.
Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of Mycosis Fungoides (MF) and Cutaneous T-cell Lymphoma (CTCL). Aberrant loss of CD7 supports a diagnosis of T-cell lymphoma over a reactive process.
Partial loss of CD7 may be seen in some T-cell lymphoproliferative disorders. This pattern requires correlation with additional immunohistochemical markers, clinical presentation, and histological findings.
Consult your doctor if you experience persistent skin patches or plaques, unexplained lumps or swelling in the neck, armpits, or groin, prolonged fever, night sweats, unexplained weight loss, fatigue, itchy skin rashes, or bone pain. These symptoms may warrant investigation for T-cell lymphomas and leukemias, and your doctor may recommend the Immunohistochemistry CD7 Test as part of the diagnostic workup.
Limitations
- ⚠This test evaluates only the CD7 marker and should be interpreted alongside a comprehensive IHC panel
- ⚠Loss of CD7 is not exclusively diagnostic of a specific lymphoma subtype and must be correlated with morphology and clinical context
- ⚠Results may be affected by pre-analytical variables such as tissue fixation and processing quality
- ⚠A negative CD7 result does not rule out T-cell malignancy as some T-cell neoplasms may retain CD7 expression
- ⚠Cannot be used as a standalone diagnostic test; always requires histopathological correlation
Risks & Considerations
- ●There are no direct risks associated with this test as it is performed on an already collected tissue specimen
- ●The biopsy procedure itself carries minimal risks such as bleeding, infection, or discomfort at the biopsy site, which are managed by the treating physician
Interfering Factors
- ●Inadequate fixation of tissue specimen leading to antigen degradation
- ●Prolonged storage of paraffin-embedded blocks resulting in loss of antigenicity
- ●Over-decalcification of bony tissue specimens
- ●Use of fixatives other than 10% neutral buffered formalin
- ●Necrotic or heavily inflamed tissue areas may yield non-representative results
Compare With Similar Tests
| Test | Immunohistochemistry CD7 Test | Immunohistochemistry CD3 Test | Immunohistochemistry CD4 Test | Immunohistochemistry CD8 Test | Immunohistochemistry CD30 Test | Flow Cytometry Immunophenotyping |
|---|---|---|---|---|---|---|
| Comparison | Immunohistochemistry CD7 Test |
Frequently Asked Questions
What is the Immunohistochemistry CD7 Test?
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