Immunohistochemistry D2-40 (Podoplanin) Test
Short Name: IHC D2-40 Podoplanin
Also known as: Podoplanin (D2-40) Immunostain, D2-40 Stain
Immunohistochemistry D2-40 (Podoplanin) Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block samples. Results in 5-7 days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to aid in the diagnosis and assessment of cancers by detecting podoplanin expression. It helps identify lymphatic invasion, which is critical for staging tumors, diagnosing mesothelioma, and evaluating vascular lesions. Results inform treatment plans and prognosis.
- Test Code
- 987
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block
- Result Time
- 5-7 days from sample receipt
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history to the lab.
Method: Biopsy or surgical excision
Laboratory Analysis
Tissue sample is obtained via biopsy or surgical procedure and preserved appropriately.
Report Delivery
Sample is transported to the lab for processing and staining.
Timeline: 5-7 days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to aid in the diagnosis and assessment of cancers by detecting podoplanin expression. It helps identify lymphatic invasion, which is critical for staging tumors, diagnosing mesothelioma, and evaluating vascular lesions. Results inform treatment plans and prognosis.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block.
- Ship the sample at room temperature.
- Include a copy of the histopathology report, site of biopsy, and clinical history.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is crucial for identifying lymphatic invasion in tumors, diagnosing vascular lesions, and confirming malignant mesothelioma, aiding in precise cancer staging and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate or insufficient tissue sample.
- Missing clinical information or histopathology report.
- Improperly fixed or contaminated samples.
Understanding Your Results
Positive
Podoplanin expression detected, indicating lymphatic involvement, possible mesothelioma, or vascular lesions. Further clinical correlation needed.
Negative
No detectable podoplanin expression. Does not rule out cancer; consider other diagnostic tests.
Consult an oncologist if you experience persistent symptoms like unexplained weight loss, lumps, or pain, or if results indicate positive staining for podoplanin.
Limitations
- ⚠Not a standalone diagnostic test; must be correlated with histopathology and clinical findings.
- ⚠Results may vary based on tissue quality and processing.
Risks & Considerations
- ●Minimal risks from biopsy procedure, such as infection or bleeding at the site.
- ●No direct risks from the staining process itself.
Interfering Factors
- ●Inadequate tissue fixation
- ●Antibody cross-reactivity
- ●Tissue necrosis or degradation
Compare With Similar Tests
| Test | Immunohistochemistry D2-40 (Podoplanin) Test | H&E Staining | Immunohistochemistry Panel | CT Scan |
|---|---|---|---|---|
| Comparison | Immunohistochemistry D2-40 (Podoplanin) Test | Routine histopathology; IHC D2-40 provides specific protein detection for lymphatic invasion. | Broader panel including multiple markers; D2-40 is specific for podoplanin. | Imaging for tumor localization; IHC D2-40 confirms histological features. |
Frequently Asked Questions
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