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DNA Labs India

Immunohistochemistry Digital Breast Cancer Panel 3 Test

DNA Labs India | ISO 9001:2015 Certified

Immunohistochemistry Digital Breast Cancer Panel 3 Test

Short Name: IHC Digital Breast Cancer Panel 3

Immunohistochemistry Digital Breast Cancer Panel 3 Test test available at DNA Labs India for ₹0. Uses Immunohistochemistry, Digital Pathology on Tumour tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block samples. Results in Report available in 5-7 days, depending on sample type (block or tissue biopsy).. Free home collection in 300+ cities across India.

Immunohistochemistry PanelPrimarily FemaleAdults🏠 Home Collection

🩺 Medically Reviewed By

Overview

The purpose of the Immunohistochemistry Digital Breast Cancer Panel 3 Test is to assess the expression of key biomarkers in breast cancer tissue: Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal Growth Factor Receptor 2 (HER-2). ER and PR status helps evaluate responsiveness to endocrine therapy, while HER-2 expression indicates suitability for targeted therapies like Herceptin. The test includes digital photomicrograph analysis and pathologist review for the presence of malignant cells, ensuring accurate diagnosis, staging, and guidance for treatment decisions in breast cancer patients.

Test Code
892
Sample Type
Tumour tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block
Result Time
Report available in 5-7 days, depending on sample type (block or tissue biopsy).
Fasting Required
No
Method
Immunohistochemistry, Digital Pathology
Step 1

Sample Collection

Ensure the tumour tissue is properly collected via biopsy. Provide a copy of the histopathology report, indicate the biopsy site, and share relevant clinical history with the healthcare provider.

Method: Tissue biopsy collection

Step 2

Laboratory Analysis

Standard tissue biopsy procedure performed by a healthcare professional, with the sample preserved in 10% formal-saline or as an FFPE block.

Step 3

Report Delivery

The tissue sample is shipped at room temperature to DNA Labs India for immunohistochemistry analysis and digital reporting.

Timeline: Report available in 5-7 days, depending on sample type (block or tissue biopsy).

Patient Instructions

1
Before the Test:Consult with an oncologist, provide necessary medical history, and ensure a biopsy has been performed to obtain tumour tissue.
2
During the Test:The collected tissue sample undergoes immunohistochemistry staining and digital imaging analysis using AI algorithms for precise biomarker detection.
3
After the Test:Discuss the test results with your doctor to understand their implications for diagnosis, staging, and treatment planning.

About This Test

Who Should Get This Test

The purpose of the Immunohistochemistry Digital Breast Cancer Panel 3 Test is to assess the expression of key biomarkers in breast cancer tissue: Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal Growth Factor Receptor 2 (HER-2). ER and PR status helps evaluate responsiveness to endocrine therapy, while HER-2 expression indicates suitability for targeted therapies like Herceptin. The test includes digital photomicrograph analysis and pathologist review for the presence of malignant cells, ensuring accurate diagnosis, staging, and guidance for treatment decisions in breast cancer patients.

How to Prepare

  • Submit tumour tissue in 10% Formal-saline or as a Formalin fixed paraffin embedded (FFPE) block
  • Ship the sample at room temperature
  • Provide a copy of the histopathology report
  • Indicate the site of biopsy
  • Provide relevant clinical history

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is essential for determining hormone receptor status (ER, PR) and HER-2 expression in breast cancer, guiding targeted therapy decisions and improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumour tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block
Sample VolumeAs required for tissue analysis
Container10% Formal-saline container or FFPE block
Collection MethodTissue biopsy collection

Sample Stability

Tissue in 10% formal-saline: stable for several days at room temperature
FFPE blocks: stable for long-term storage at room temperature
Sample Rejection Criteria:
  • Poorly fixed or degraded tissue
  • Insufficient tissue quantity for analysis
  • Missing or incomplete clinical information

Understanding Your Results

The results of the Immunohistochemistry Digital Breast Cancer Panel 3 Test are interpreted based on the expression levels of ER, PR, and HER-2 in the breast cancer tissue. Positive ER or PR status indicates potential responsiveness to endocrine therapy, while HER-2 positivity suggests eligibility for targeted therapies. Digital photomicrographs and pathologist review provide visual confirmation of malignant cells and biomarker expression.
ER Positive: Tumour cells show nuclear staining for estrogen receptor, indicating likely benefit from endocrine therapy (e.g., tamoxifen)
PR Positive: Tumour cells show nuclear staining for progesterone receptor, supporting endocrine therapy responsiveness
ER/PR Negative: No significant staining, suggesting endocrine therapy may be less effective
HER-2 Positive (3+): Strong membrane staining, indicating responsiveness to HER-2 targeted therapies like Herceptin
HER-2 Equivocal (2+): Requires further testing such as FISH for confirmation
HER-2 Negative (0 or 1+): No overexpression, HER-2 targeted therapy not indicated
⚠️ When to Consult a Doctor:

Consult your oncologist or healthcare provider if you experience symptoms of breast cancer, such as a lump, breast changes, or nipple discharge, or for follow-up after diagnosis to discuss test results and treatment options.

Limitations

  • Results depend on tissue quality and sample adequacy
  • HER-2 equivocal results (2+) may require additional fluorescence in situ hybridization (FISH) testing
  • Test does not detect all genetic mutations associated with breast cancer

Risks & Considerations

  • Minimal risks associated with biopsy collection, such as infection, bleeding, or discomfort at the biopsy site
  • No direct risks from the immunohistochemistry test itself

Interfering Factors

  • Poor tissue fixation or preservation
  • Insufficient or inadequate tissue sample
  • Technical errors in immunohistochemistry processing

Frequently Asked Questions

What is the Immunohistochemistry Digital Breast Cancer Panel 3 Test?
It is a diagnostic test that uses immunohistochemistry and digital imaging to assess ER, PR, and HER-2 biomarkers in breast cancer tissue for accurate diagnosis and treatment guidance.
Why is this test important for breast cancer patients?
This test helps determine hormone receptor status and HER-2 expression, which are crucial for selecting targeted therapies like endocrine treatment or Herceptin, improving treatment outcomes.
What sample is required for this test?
A tumour tissue sample collected via biopsy, submitted in 10% formal-saline or as a formalin fixed paraffin embedded (FFPE) block, with a histopathology report and clinical history.
How is the test performed?
The tissue sample is processed using immunohistochemistry stains, analyzed with digital imaging and AI algorithms, and reviewed by a pathologist to detect biomarker expression and malignant cells.
What do the results mean?
Positive ER or PR indicates potential benefit from endocrine therapy, while HER-2 positivity suggests responsiveness to targeted treatments. Negative results may guide alternative therapies.
How long does it take to get results?
Reports are typically available within 5-7 days after sample receipt, depending on whether the sample is a block or tissue biopsy.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India, with the test cost at a discounted price of Rs 0.
What is the cost of this test?
The test costs Rs 0, with special discounted pricing offered by DNA Labs India, including home collection services.
Are there any risks associated with this test?
The test itself has no direct risks, but biopsy collection may involve minor risks like infection or bleeding, which are standard for tissue sampling procedures.
Can this test detect all types of breast cancer?
This test assesses specific biomarkers in breast cancer tissue but does not detect all genetic mutations or subtypes; additional tests may be needed for comprehensive evaluation.
How should I prepare for the test?
No specific preparation is required, but ensure your healthcare provider has collected a biopsy and provided all necessary clinical information and histopathology report.
What if my HER-2 result is equivocal?
An equivocal HER-2 result (2+) may require further testing, such as fluorescence in situ hybridization (FISH), to confirm HER-2 status for accurate treatment planning.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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