Immunohistochemistry E-Cadherin (ECAD) Test
Short Name: ECAD IHC Test
Also known as: E-Cadherin, ECAD
Immunohistochemistry E-Cadherin (ECAD) Test test available at DNA Labs India for ₹3,000. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports available in 5-7 days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Immunohistochemistry E-Cadherin (ECAD) Test is to evaluate the expression of E-cadherin in tissue samples, which is critical for diagnosing and characterizing cancers. E-cadherin loss is a hallmark of epithelial-mesenchymal transition, contributing to cancer invasion and metastasis. This test assists oncologists and pathologists in determining cancer type, aggressiveness, and prognosis, particularly in breast, gastric, colorectal, and pancreatic cancers. It aids in differentiating between cancer subtypes, such as ductal and lobular carcinoma of the breast, and guides treatment decisions.
- Test Code
- 994
- Price
- ₹3,000
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Reports available in 5-7 days from sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history.
Method: Biopsy or surgery
Laboratory Analysis
Sample collected via biopsy or surgery from the tumor site.
Report Delivery
Tissue is fixed in 10% formal-saline or embedded in paraffin block, then transported at room temperature.
Timeline: Reports available in 5-7 days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Immunohistochemistry E-Cadherin (ECAD) Test is to evaluate the expression of E-cadherin in tissue samples, which is critical for diagnosing and characterizing cancers. E-cadherin loss is a hallmark of epithelial-mesenchymal transition, contributing to cancer invasion and metastasis. This test assists oncologists and pathologists in determining cancer type, aggressiveness, and prognosis, particularly in breast, gastric, colorectal, and pancreatic cancers. It aids in differentiating between cancer subtypes, such as ductal and lobular carcinoma of the breast, and guides treatment decisions.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Ship at room temperature
- Provide a copy of the histopathology report, site of biopsy, and clinical history
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"E-cadherin loss is a key indicator in breast and other cancers, aiding in diagnosis, prognosis, and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improper fixation or container
- Missing clinical information
Understanding Your Results
If you experience persistent symptoms like unexplained weight loss, fatigue, or abnormal bleeding, or if test results indicate abnormal E-cadherin expression.
Limitations
- ⚠False negatives or positives possible
- ⚠Requires expert pathologist interpretation
- ⚠Not definitive alone; often used with other tests
Risks & Considerations
- ●Minimal risks from biopsy procedure, such as infection or bleeding
- ●No direct risks from the test itself
Interfering Factors
- ●Poor tissue fixation
- ●Inadequate sample size
- ●Antibody specificity issues
- ●Technical errors in staining
Compare With Similar Tests
| Test | Immunohistochemistry E-Cadherin (ECAD) Test | HER2 IHC | Ki-67 IHC | p53 IHC | Estrogen Receptor IHC |
|---|---|---|---|---|---|
| Comparison | Immunohistochemistry E-Cadherin (ECAD) Test |
Frequently Asked Questions
What is the Immunohistochemistry E-Cadherin (ECAD) Test?
Why is the ECAD test performed?
How is the sample collected for the ECAD test?
What does a positive ECAD test result mean?
What does a negative or loss of ECAD expression indicate?
Is the ECAD test used for all types of cancer?
How long does it take to get ECAD test results?
What is the cost of the ECAD test in India?
Does the test require fasting or special preparation?
Can the ECAD test be done at home?
Are there any risks associated with the test?
How accurate is the ECAD test?
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