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DNA Labs India

Immunohistochemistry Glutamine Synthetase Test

DNA Labs India | ISO 9001:2015 Certified

Immunohistochemistry Glutamine Synthetase Test

Short Name: IHC Glutamine Synthetase Test

Also known as: GS IHC Test, Glutamine Synthetase Immunohistochemistry

Immunohistochemistry Glutamine Synthetase Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue samples. Results in 5-7 days from sample receipt.. Free home collection in 300+ cities across India.

ImmunohistochemistryAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect and locate glutamine synthetase in tissue samples for diagnosing liver disease, kidney disease, brain tumors, and distinguishing hepatic adenoma from focal nodular hyperplasia.

Test Code
1000
Price
₹3,500
Sample Type
Tumor tissue
Result Time
5-7 days from sample receipt.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Method: Biopsy or surgery

Step 2

Laboratory Analysis

Sample collection via biopsy or surgery as per standard procedure.

Step 3

Report Delivery

Sample is processed and stained for immunohistochemistry analysis.

Timeline: 5-7 days from sample receipt.

Patient Instructions

1
Before the Test:Ensure all necessary reports and clinical history are provided.
2
During the Test:Tissue sample is processed and stained with antibodies specific to glutamine synthetase.
3
After the Test:Results are analyzed by a pathologist and reported.

About This Test

Who Should Get This Test

To detect and locate glutamine synthetase in tissue samples for diagnosing liver disease, kidney disease, brain tumors, and distinguishing hepatic adenoma from focal nodular hyperplasia.

How to Prepare

  • Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block
  • Ship at room temperature
  • Provide histopathology report and clinical history

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is crucial for accurate classification of hepatic adenomas and identification of focal nodular hyperplasia, aiding in targeted cancer treatment."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor tissue
Sample VolumeAs required
ContainerFormalin container or paraffin block
Collection MethodBiopsy or surgery

Sample Stability

Room temperature: up to 24 hours
Formalin-fixed: stable for extended periods
Sample Rejection Criteria:
  • Sample not in proper container
  • Missing clinical information
  • Degraded tissue

Understanding Your Results

Results indicate the presence and pattern of glutamine synthetase expression, which helps in diagnosing various conditions.
📊

Normal liver pattern

📊

Suggestive of Focal Nodular Hyperplasia

📊

May indicate Hepatic Adenoma with beta-catenin mutation

📊

May indicate other liver conditions or inadequate staining

⚠️ When to Consult a Doctor:

If symptoms persist or results are abnormal, consult an oncologist or hepatologist for further evaluation.

Limitations

  • ⚠Results depend on tissue quality and handling
  • ⚠Interpretation requires specialized expertise
  • ⚠May not detect all variants of glutamine synthetase

Risks & Considerations

  • ●Risks associated with biopsy procedure, such as infection or bleeding
  • ●Allergic reaction to stains is rare

Interfering Factors

  • ●Tissue degradation
  • ●Contamination
  • ●Technical errors in staining

Compare With Similar Tests

TestImmunohistochemistry Glutamine Synthetase TestBeta-catenin ImmunohistochemistryLiver Fatty Acid Binding Protein Test
ComparisonImmunohistochemistry Glutamine Synthetase Test

Frequently Asked Questions

What is the Immunohistochemistry Glutamine Synthetase Test?
It is a diagnostic test that uses antibodies to detect the enzyme glutamine synthetase in tissue samples, helping to diagnose diseases like liver disorders, kidney diseases, and brain tumors.
Why is this test performed?
To identify the presence and location of glutamine synthetase in tissues, which is crucial for diagnosing conditions such as hepatic adenoma, focal nodular hyperplasia, and other cancers.
How is the test done?
A tissue sample from a biopsy or surgery is processed, sliced, and treated with antibodies that bind to glutamine synthetase. The sample is then examined under a microscope to detect the enzyme.
What is the cost of the Immunohistochemistry Glutamine Synthetase Test?
The cost is INR 3500.0 at DNA Labs India, with free home sample collection available across India.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection in numerous cities across India for this test.
How long does it take to get the results?
Results are typically available within 5-7 days from the receipt of the sample.
What symptoms may indicate the need for this test?
Symptoms such as abdominal pain, nausea, vomiting, jaundice, confusion, memory loss, headaches, or seizures may lead a doctor to order this test.
What is glutamine synthetase?
Glutamine synthetase is an enzyme that catalyzes the conversion of glutamate to glutamine, playing a key role in nitrogen metabolism and preventing ammonia accumulation.
How does this test help in cancer diagnosis?
It helps distinguish between hepatic adenoma and focal nodular hyperplasia, which is essential for accurate cancer classification and treatment planning.
What type of sample is required for this test?
A tumor tissue sample, either in 10% formal-saline or as a formalin-fixed paraffin-embedded block, is required.
Is fasting required before the test?
No, fasting is not required. However, providing the histopathology report, site of biopsy, and clinical history is necessary.
Are there any risks associated with this test?
The test itself has minimal risks, but the biopsy procedure may carry risks such as infection or bleeding. Allergic reactions to stains are rare.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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