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Immunohistochemistry Myeloperoxidase (MPO) Test

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Immunohistochemistry Myeloperoxidase (MPO) Test

Short Name: MPO IHC Test

Also known as: MPO Immunohistochemistry, Myeloperoxidase Staining Test

Immunohistochemistry Myeloperoxidase (MPO) Test test available at DNA Labs India for ₹3,000. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports are delivered within 5-7 business days after sample collection, depending on sample type.. Free home collection in 300+ cities across India.

Immunohistochemistry🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify the presence of myeloperoxidase in tissue samples, aiding in the diagnosis and classification of myeloid cell malignancies (e.g., acute myeloid leukemia) and certain autoimmune conditions.

Test Code
913
Price
₹3,000
Sample Type
Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
Result Time
Reports are delivered within 5-7 business days after sample collection, depending on sample type.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Ensure a copy of the histopathology report, site of biopsy, and detailed clinical history are available.

Method: Biopsy

Step 2

Laboratory Analysis

The biopsy procedure is performed by a qualified healthcare provider; tissue is collected and preserved in formalin.

Step 3

Report Delivery

Monitor the biopsy site for signs of infection or bleeding; follow standard post-biopsy care instructions.

Timeline: Reports are delivered within 5-7 business days after sample collection, depending on sample type.

Patient Instructions

1
Before the Test:A biopsy procedure may be required to obtain tissue. No specific preparation is needed, but inform your doctor about any medications or allergies.
2
During the Test:The biopsy is performed under local anesthesia; the tissue is then processed and stained in the lab using immunohistochemical methods.
3
After the Test:Resume normal activities unless advised otherwise. Results are typically available within 5-7 days.

About This Test

Who Should Get This Test

To identify the presence of myeloperoxidase in tissue samples, aiding in the diagnosis and classification of myeloid cell malignancies (e.g., acute myeloid leukemia) and certain autoimmune conditions.

How to Prepare

  • Submit tumor tissue in 10% Formal-saline or as a Formalin fixed paraffin embedded block.
  • Ship at room temperature.
  • Provide a copy of the histopathology report, site of biopsy, and clinical history with the sample.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The IHC MPO Test is essential for identifying myeloid cell malignancies, such as acute myeloid leukemia, and guiding treatment strategies based on tumor immunophenotype."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
Sample VolumeAdequate tissue biopsy
ContainerFormalin container
Collection MethodBiopsy

Sample Stability

Stable in formalin at room temperature for up to 7 days.
Paraffin blocks can be stored long-term at room temperature.
Sample Rejection Criteria:
  • Inadequate tissue sample
  • Improper fixation or container leakage
  • Missing clinical information or histopathology report

Understanding Your Results

The IHC MPO Test results are interpreted based on the presence or absence of myeloperoxidase staining in tissue cells. A positive result indicates MPO expression, which is characteristic of myeloid cells and may suggest myeloid malignancies like AML. Negative results may point to other lineages. Always consult with a pathologist and oncologist for accurate diagnosis.
Positive MPO staining: Suggests myeloid lineage, common in acute myeloid leukemia subtypes.
Negative MPO staining: Indicates non-myeloid origin, requiring further testing for alternative diagnoses.
Weak or focal staining: May require additional markers for confirmation.
⚠️ When to Consult a Doctor:

If you experience symptoms like unexplained weight loss, persistent fever, fatigue, joint pain, or abnormal bleeding, consult an oncologist or hematologist to discuss the need for this test based on clinical evaluation.

Limitations

  • ⚠Results are qualitative and must be correlated with clinical findings and other tests.
  • ⚠Not a standalone diagnostic tool; requires integration with histopathology and clinical history.
  • ⚠Sensitivity may vary based on tissue preparation and laboratory expertise.

Risks & Considerations

  • ●Biopsy-related risks: minor bleeding, infection, or discomfort at the biopsy site.
  • ●False-positive or false-negative results due to technical factors, requiring correlation with clinical data.

Interfering Factors

  • ●Poor tissue fixation or embedding
  • ●Inadequate biopsy sample size
  • ●Antibody cross-reactivity or degradation
  • ●Use of incorrect staining protocols

Compare With Similar Tests

TestImmunohistochemistry Myeloperoxidase (MPO) TestFlow CytometryBone Marrow Biopsy
ComparisonImmunohistochemistry Myeloperoxidase (MPO) TestUsed for cell surface marker analysis; IHC MPO provides tissue-based detection.IHC MPO is often performed on biopsy samples to enhance diagnostic accuracy.

Frequently Asked Questions

What is the Immunohistochemistry Myeloperoxidase (MPO) Test?
It is a laboratory test that uses antibodies to detect the presence of myeloperoxidase enzyme in tissue samples, helping diagnose myeloid leukemias and autoimmune diseases.
Why is the MPO Test performed?
To identify myeloid cell malignancies like acute myeloid leukemia (AML) and to differentiate between various types of blood cancers or autoimmune conditions.
What sample is required for the MPO Test?
A tissue biopsy sample, submitted in 10% formal-saline or as a formalin-fixed paraffin-embedded block, along with histopathology report and clinical history.
How much does the MPO Test cost?
At DNA Labs India, the cost is INR 3000, which includes home sample collection across many cities in India.
Is fasting required for the MPO Test?
No, fasting is not required as the test is performed on tissue samples, not blood.
How long does it take to get MPO Test results?
Results are typically available within 5-7 business days after sample receipt, with reports delivered online, via email, or WhatsApp.
What are the risks of the MPO Test?
The test itself has minimal risks; however, the biopsy procedure may involve minor bleeding or infection at the site.
Can the MPO Test diagnose all types of cancer?
No, it is specific for myeloid cell disorders and may not detect cancers of other lineages; additional tests are often needed.
What does a positive MPO Test result mean?
A positive result indicates the presence of myeloperoxidase, suggesting myeloid cell involvement, common in conditions like AML.
What does a negative MPO Test result mean?
A negative result suggests absence of myeloperoxidase, pointing to non-myeloid origins; further evaluation is recommended.
Is home sample collection available for the MPO Test?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How should I prepare for the MPO Test?
Provide a copy of your histopathology report, biopsy site details, and clinical history. No special preparation is needed for the biopsy itself.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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