Immunohistochemistry P40 Test
Short Name: IHC P40 Test
Also known as: P40 Immunohistochemistry, IHC P40 Stain, P40 Protein Detection Test
Immunohistochemistry P40 Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Results available within 5-7 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Immunohistochemistry P40 test is to detect P40 protein expression in tissue biopsies, aiding in the accurate diagnosis and subtyping of cancers, particularly squamous cell carcinoma in the lungs and head/neck regions.
- Test Code
- 1018
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Results available within 5-7 days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, biopsy site, and clinical history. No special preparation needed for the patient.
Method: Tissue Biopsy
Laboratory Analysis
Tissue biopsy is performed by a healthcare professional to obtain a sample from the affected area.
Report Delivery
Submit the tumor tissue in appropriate container and ship to the lab at room temperature.
Timeline: Results available within 5-7 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Immunohistochemistry P40 test is to detect P40 protein expression in tissue biopsies, aiding in the accurate diagnosis and subtyping of cancers, particularly squamous cell carcinoma in the lungs and head/neck regions.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Ship at room temperature
- Provide a copy of the Histopathology report, Site of biopsy, and Clinical history
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"P40 is a highly specific marker (96% specificity) for squamous cell carcinoma, essential for differentiating non-small cell lung cancer subtypes and guiding targeted therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improper container or fixation
- Missing clinical history or biopsy site information
Understanding Your Results
Positive for P40
Strong indication of squamous cell carcinoma, with 96% specificity. Further clinical correlation recommended.
Negative for P40
Suggests absence of squamous cell carcinoma; may indicate other cancer types like adenocarcinoma or benign conditions.
Consult an oncologist if results are positive, if symptoms persist, or for further diagnostic evaluation and treatment planning.
Limitations
- ⚠False positives in rare cases (4.6% of adenocarcinomas may express P40)
- ⚠Test is specific to squamous cell carcinoma and may not detect all cancer types
- ⚠Requires high-quality tissue samples for accurate results
Risks & Considerations
- ●Minimal risks associated with tissue biopsy, such as infection or bleeding
- ●False positive or negative results due to sample quality
Interfering Factors
- ●Improper tissue fixation
- ●Sample degradation or contamination
- ●Inadequate clinical history or biopsy site information
Compare With Similar Tests
| Test | Immunohistochemistry P40 Test | Immunohistochemistry P63 | EGFR Mutation Test | PD-L1 Expression Test |
|---|---|---|---|---|
| Comparison | Immunohistochemistry P40 Test | P40 has higher specificity (96%) for squamous cell carcinoma compared to P63, which is less specific. | EGFR test targets genetic mutations in adenocarcinoma, while P40 is for protein expression in squamous cell carcinoma. | PD-L1 assesses immunotherapy eligibility, whereas P40 aids in cancer subtyping. |
Frequently Asked Questions
What is the Immunohistochemistry P40 test?
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Can the P40 test detect all types of cancer?
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How is the P40 test different from the P63 test?
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