Immunohistochemistry SOX-10 Test
Short Name: SOX-10 IHC Test
Also known as: SOX-10 Immunohistochemistry, SOX-10 IHC Staining
Immunohistochemistry SOX-10 Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Report available within 5-7 days after sample receipt, depending on sample type.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To detect SOX-10 protein expression in tissue samples for diagnosing melanoma, schwannoma, neurofibroma, and other neural crest-derived tumors.
- Test Code
- 1037
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Report available within 5-7 days after sample receipt, depending on sample type.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history.
Method: Biopsy or surgical specimen collection
Laboratory Analysis
Tissue sample is collected via biopsy or surgical procedure and preserved appropriately.
Report Delivery
Sample is processed, stained with SOX-10 antibodies, and examined microscopically.
Timeline: Report available within 5-7 days after sample receipt, depending on sample type.
Patient Instructions
About This Test
Who Should Get This Test
To detect SOX-10 protein expression in tissue samples for diagnosing melanoma, schwannoma, neurofibroma, and other neural crest-derived tumors.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Ship at room temperature
- Include histopathology report, biopsy site details, and clinical history
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is crucial for accurate diagnosis of neural crest-derived tumors, aiding in treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improper fixation or preservation
- Missing clinical information
Understanding Your Results
Positive SOX-10 expression
Suggests melanoma, schwannoma, neurofibroma, or other SOX-10 positive tumors; correlates with neural crest origin.
Negative SOX-10 expression
May indicate absence of these tumors or less differentiated variants; further testing recommended.
Weak or focal staining
Could represent heterogeneity or early stages; clinical context is essential for diagnosis.
If you experience symptoms such as new or changing moles, skin lumps, numbness, weakness, or pain in affected areas, consult an oncologist or dermatologist for evaluation.
Limitations
- ⚠Not a standalone diagnostic tool
- ⚠Requires correlation with clinical and histopathological findings
- ⚠May not detect all variants of tumors
- ⚠Results depend on specimen adequacy
Risks & Considerations
- ●Minimal risks from biopsy procedure, such as infection or bleeding
- ●No direct risks from the IHC test itself
Interfering Factors
- ●Inadequate tissue fixation
- ●Poor sample quality
- ●Antibody cross-reactivity
- ●Technical errors in staining
Compare With Similar Tests
| Test | Immunohistochemistry SOX-10 Test | S-100 Protein Test | HMB-45 Test |
|---|---|---|---|
| Comparison | Immunohistochemistry SOX-10 Test | Also used for melanoma and nerve sheath tumors but less specific than SOX-10 for spindle cell melanoma. | Commonly used for melanoma detection; SOX-10 is more sensitive for desmoplastic melanoma. |
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