Immunohistochemistry TTF-1 (Thyroid Transcription Factor-1) Test
Short Name: TTF-1 IHC Test
Also known as: TTF-1 IHC Test, Thyroid Transcription Factor-1 Test, TTF-1 Protein Detection Test
Immunohistochemistry TTF-1 (Thyroid Transcription Factor-1) Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Report available in 5-7 days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Immunohistochemistry TTF-1 test is to detect TTF-1 protein expression in tissue samples, aiding in the diagnosis of lung adenocarcinomas and thyroid neoplasms. It helps identify the origin of tumors, differentiate between cancer types, and assist in treatment planning.
- Test Code
- 1050
- Price
- ₹3,500
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Report available in 5-7 days from sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the Histopathology report, site of biopsy, and clinical history.
Method: Tissue Biopsy
Laboratory Analysis
Tissue biopsy is performed by a healthcare professional, and the sample is collected in a suitable container.
Report Delivery
Store the sample at room temperature and ship to the laboratory as per instructions.
Timeline: Report available in 5-7 days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Immunohistochemistry TTF-1 test is to detect TTF-1 protein expression in tissue samples, aiding in the diagnosis of lung adenocarcinomas and thyroid neoplasms. It helps identify the origin of tumors, differentiate between cancer types, and assist in treatment planning.
How to Prepare
- Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Ship the sample at room temperature
- Include a copy of the histopathology report, site of biopsy, and clinical history
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate or damaged tissue sample
- Missing clinical history or biopsy site information
- Improperly fixed or preserved tissue
Understanding Your Results
Positive for TTF-1
Indicates expression of TTF-1 protein, commonly associated with lung adenocarcinoma or thyroid neoplasms. Supports diagnosis of tumors of lung or thyroid origin.
Negative for TTF-1
No detectable TTF-1 protein expression. May suggest tumors from other origins or require further testing for confirmation.
If you are experiencing symptoms such as coughing up blood, chest pain, shortness of breath, hoarseness, unexplained weight loss, or fatigue, or if you have a biopsy indicating possible lung cancer or thyroid neoplasms, consult an oncologist or pathologist for proper diagnosis and treatment.
Limitations
- ⚠Test results should be interpreted in conjunction with clinical history and other diagnostic tests
- ⚠False negatives can occur due to low protein expression or technical issues
- ⚠Not all lung cancers or thyroid neoplasms express TTF-1
Risks & Considerations
- ●Minimal risks associated with tissue biopsy, such as infection or bleeding at the biopsy site
Interfering Factors
- ●Improper tissue fixation or handling
- ●Delayed sample processing
- ●Use of inappropriate fixatives
- ●Inadequate tissue sample size
Compare With Similar Tests
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|---|---|---|---|---|
| Comparison | Immunohistochemistry TTF-1 (Thyroid Transcription Factor-1) Test |
Frequently Asked Questions
What is the Immunohistochemistry TTF-1 test?
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What sample is required for the TTF-1 test?
How much does the TTF-1 test cost in India?
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Can the TTF-1 test be used for monitoring treatment?
What should I do if I have symptoms of lung cancer?
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