Immunohistochemistry Microsatellite Instability Panel Test
Short Name: IHC MSI Panel Test
Also known as: IHC MSI Panel, Microsatellite Instability Test, Mismatch Repair Protein Panel
Immunohistochemistry Microsatellite Instability Panel Test test available at DNA Labs India for ₹10,000. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block samples. Results in Reports available within 5-7 business days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
This panel studies mismatch repair proteins (MLH-1, MSH-2, MSH-6, PMS-2) to identify microsatellite instability, aiding in the diagnosis of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome and guiding cancer treatment strategies.
- Test Code
- 1099
- Price
- ₹10,000
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block
- Result Time
- Reports available within 5-7 business days after sample receipt.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history to the lab.
Method: Biopsy or surgical excision
Laboratory Analysis
Tumor tissue sample collected via biopsy or surgical excision, placed in 10% formal-saline or prepared as FFPE block.
Report Delivery
Sample shipped at room temperature to the laboratory for processing and analysis.
Timeline: Reports available within 5-7 business days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
This panel studies mismatch repair proteins (MLH-1, MSH-2, MSH-6, PMS-2) to identify microsatellite instability, aiding in the diagnosis of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome and guiding cancer treatment strategies.
How to Prepare
- Submit tumor tissue in 10% formal-saline or as FFPE block
- Include histopathology report and clinical details
- Ship sample at room temperature
- Ensure proper labeling and documentation
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early detection of microsatellite instability through IHC MSI Panel is crucial for identifying Lynch syndrome and personalizing cancer therapy, improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue sample
- Improperly fixed or labeled specimens
- Missing clinical information or histopathology report
Understanding Your Results
All proteins intact (positive)
No evidence of MSI; low risk for Lynch syndrome, but clinical correlation needed.
Loss of one or more proteins
Possible MSI-high or dMMR; suggestive of Lynch syndrome or sporadic cancer with MSI; recommend genetic testing.
Inconclusive
Repeat testing or consider PCR-based MSI testing for confirmation.
Consult an oncologist or genetic counselor if results indicate loss of MMR proteins, especially with a family history of cancer or young age at diagnosis.
Limitations
- ⚠Not a standalone diagnostic tool; requires correlation with clinical and family history
- ⚠May have false negatives due to sampling errors
- ⚠Results can be affected by pre-analytical variables
- ⚠Interpretation requires expertise in pathology
Risks & Considerations
- ●Minimal risks associated with biopsy collection, such as bleeding or infection
- ●Test itself poses no direct risk as it is performed on already collected tissue
Interfering Factors
- ●Inadequate tissue fixation
- ●Tissue necrosis or insufficient sample
- ●Technical errors in staining process
- ●Use of incorrect antibodies
Compare With Similar Tests
| Test | Immunohistochemistry Microsatellite Instability Panel Test | PCR-based MSI Testing | Next-Generation Sequencing (NGS) | Single Gene IHC |
|---|---|---|---|---|
| Comparison | Immunohistochemistry Microsatellite Instability Panel Test |
Frequently Asked Questions
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