KANK1 Gene Cerebral Palsy Type 2, Spastic Quadriplegic NGS Genetic Test
Short Name: KANK1 NGS
Also known as: KANK1 Gene Test, Cerebral Palsy Type 2 Genetic Test, Spastic Quadriplegic Cerebral Palsy NGS Test
KANK1 Gene Cerebral Palsy Type 2, Spastic Quadriplegic NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 4 weeks after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect disease-associated variants in the KANK1 gene in individuals with suspected spastic quadriplegic cerebral palsy type 2. Genetic confirmation supports early diagnosis, recurrence risk counselling, and personalised management.
- Test Code
- 3955
- ICD Code
- G80.0
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally available within 4 weeks after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counselling session is recommended before the test to document clinical history and draw a pedigree chart of family members affected with KANK1-related cerebral palsy.
Method: Venous blood collection or FTA card spot
Laboratory Analysis
A blood sample is collected by an experienced phlebotomist. If an FTA card is used, only one drop of blood is required.
Report Delivery
No special precautions are needed after collection. The sample is transported to the laboratory under recommended conditions.
Timeline: Reports are generally available within 4 weeks after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect disease-associated variants in the KANK1 gene in individuals with suspected spastic quadriplegic cerebral palsy type 2. Genetic confirmation supports early diagnosis, recurrence risk counselling, and personalised management.
How to Prepare
- Ensure the test request form and clinical notes are complete
- Use an EDTA vacutainer for blood sample collection
- For FTA card collection, apply a single drop of blood on the marked circles
- Label the sample carefully with patient name, ID, and collection date
- Keep the FTA card dry and protected from moisture
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic confirmation can help families understand the cause of cerebral palsy and access tailored medical and developmental support."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed blood sample
- Mismatched patient identification details
- Leaking or damaged sample container
- Insufficient DNA quantity or poor quality
- Sample submitted without clinical history or consent
Understanding Your Results
Positive
A pathogenic or likely pathogenic variant was detected in the KANK1 gene, confirming the genetic diagnosis in the appropriate clinical context.
Negative
No pathogenic variant was detected in the KANK1 gene. Other genetic and non-genetic causes should be considered.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is unclear. Additional testing of family members may help reclassify the variant.
Please consult a neurologist, pediatric neurologist, or clinical geneticist if the test result is positive or uncertain, or if you have concerns about the clinical features.
Limitations
- ⚠This test is limited to the KANK1 gene and reportable regions; deep intronic and regulatory variants may not be covered
- ⚠Chromosomal rearrangements may not be reliably detected by this test
- ⚠Variants of uncertain significance may require additional family studies
- ⚠A negative result does not rule out other genetic or non-genetic causes of cerebral palsy
Risks & Considerations
- ●Mild pain or bruising at the blood collection site
- ●Dizziness during or after blood collection
- ●Very small risk of infection at the venipuncture site
Interfering Factors
- ●Low-quality DNA may reduce sequencing depth
- ●Incorrect sample labeling or contaminated blood may affect results
- ●Presence of homologous sequences may complicate variant analysis
- ●Incomplete clinical information may limit interpretation
Compare With Similar Tests
| Test | KANK1 Gene Cerebral Palsy Type 2, Spastic Quadriplegic NGS Genetic Test | Targeted KANK1 Gene NGS | Cerebral Palsy Multigene NGS Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | KANK1 Gene Cerebral Palsy Type 2, Spastic Quadriplegic NGS Genetic Test |
Frequently Asked Questions
What is the KANK1 gene cerebral palsy type 2 spastic quadriplegic NGS genetic test?
What is the cost of this test at DNA Labs India?
What sample is required for the KANK1 gene test?
Is fasting required before the test?
Who should get this genetic test?
What does the NGS test look for?
Is genetic counselling needed before the test?
How will I receive the report?
Will I receive raw data files with the report?
Can this test confirm spastic quadriplegic cerebral palsy?
What is a variant of uncertain significance (VUS)?
What should I do after getting the result?
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