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KCND3 Gene Spinocerebellar ataxia type 22, autosomal dominant NGS Genetic Test

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KCND3 Gene Spinocerebellar ataxia type 22, autosomal dominant NGS Genetic Test

Short Name: SCA22 NGS Genetic Test

Also known as: Spinocerebellar ataxia type 22, SCA22

KCND3 Gene Spinocerebellar ataxia type 22, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Spinocerebellar ataxia type 22 by detecting mutations in the KCND3 gene using NGS technology, aiding in clinical management and genetic counseling.

Test Code
1833
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session recommended to discuss test implications and family history.

Method: Blood draw or saliva

Step 2

Laboratory Analysis

Standard blood draw or saliva collection using sterile equipment.

Step 3

Report Delivery

Sample is transported to the laboratory under appropriate conditions for analysis.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Undergo genetic counseling to understand the test, implications, and provide informed consent. Share detailed family medical history.
2
During the Test:Provide a blood or saliva sample as per collection instructions. The procedure is minimally invasive.
3
After the Test:Wait for the report, typically 3-4 weeks. Discuss results with a genetic counselor or neurologist for next steps.

About This Test

Who Should Get This Test

To diagnose Spinocerebellar ataxia type 22 by detecting mutations in the KCND3 gene using NGS technology, aiding in clinical management and genetic counseling.

How to Prepare

  • Use sterile collection kits
  • Label samples with patient details
  • Avoid hemolysis in blood samples

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Consult a neurologist for evaluation if symptoms suggestive of SCA22 are present."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva

Sample Stability

Blood sample stable for 7 days at room temperature
Extracted DNA stable for 1 year at -20°C
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the KCND3 gene associated with SCA22.
📊

Positive for pathogenic variant

Confirms diagnosis of SCA22. Genetic counseling and family screening recommended. Management focuses on symptom relief and support.

📊

Negative for pathogenic variant

SCA22 is unlikely, but other genetic or non-genetic causes of ataxia should be considered. Clinical correlation is advised.

⚠️ When to Consult a Doctor:

If experiencing symptoms such as uncoordinated movements, balance issues, or slurred speech, or if there is a family history of SCA22, consult a neurologist or geneticist.

Limitations

  • ⚠Test only detects mutations in the KCND3 gene
  • ⚠May not detect all genetic causes of ataxia
  • ⚠Results require interpretation by a geneticist or neurologist

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic results on patient and family

Interfering Factors

  • ●Poor sample quality
  • ●Contamination
  • ●Insufficient DNA yield

Frequently Asked Questions

What is Spinocerebellar ataxia type 22 (SCA22)?
SCA22 is a rare hereditary neurodegenerative disorder caused by mutations in the KCND3 gene, leading to uncoordinated movements and other neurological symptoms.
What are the symptoms of SCA22?
Symptoms include uncoordinated movements, balance difficulties, slurred speech, muscle weakness, atrophy, and vision problems, often appearing in middle age.
How is SCA22 diagnosed?
Diagnosis is through genetic testing, specifically NGS analysis of the KCND3 gene, often confirmed with a blood or saliva sample.
What is the cost of the KCND3 gene test?
The test costs INR 20,000 at DNA Labs India, with home sample collection included.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Reports are typically delivered in 3 to 4 weeks from sample collection.
What does a positive result mean?
A positive result confirms a diagnosis of SCA22, and genetic counseling is recommended for management and family planning.
What does a negative result mean?
A negative result makes SCA22 unlikely, but other causes of ataxia may need investigation with clinical correlation.
Is genetic testing necessary for SCA22?
Yes, genetic testing is essential for accurate diagnosis, especially with symptoms or family history, to guide treatment and counseling.
Can SCA22 be treated?
There is no cure for SCA22, but management focuses on symptom relief, physical therapy, and supportive care. Genetic counseling helps in planning.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. DNA Labs India offers discounted rates but insurance may not cover genetic tests.
How to prepare for the test?
Prepare by undergoing genetic counseling, providing detailed medical and family history, and following sample collection instructions.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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