KIF5A Gene SPG10 NGS Genetic Test
Short Name: KIF5A-SPG10 NGS
Also known as: KIF5A Gene Test, SPG10 Genetic Test, KIF5A NGS Test
KIF5A Gene SPG10 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger Sequencing for variant confirmation on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally issued in 3 to 4 weeks after the sample reaches the DNA Labs India laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic or likely pathogenic variants in the KIF5A gene to confirm or exclude a diagnosis of SPG10, distinguish it from other hereditary spastic paraplegia subtypes, and provide reliable information for medical management and genetic counselling.
- Test Code
- 4519
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally issued in 3 to 4 weeks after the sample reaches the DNA Labs India laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger Sequencing for variant confirmation
Sample Collection
No fasting or special preparation is required. The patient should carry a valid prescription or referral and a government-issued identification. A genetic counselling session to draw a family pedigree is part of the pre-test process.
Method: Blood draw / dried blood spot on FTA card / extracted DNA submission
Laboratory Analysis
A trained phlebotomist will collect blood in an EDTA vacutainer, or a drop of blood may be spotted on an FTA card. The procedure takes only a few minutes.
Report Delivery
You can resume normal activities immediately. The sample is transported to the laboratory in a temperature-controlled manner for NGS analysis.
Timeline: Reports are generally issued in 3 to 4 weeks after the sample reaches the DNA Labs India laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic or likely pathogenic variants in the KIF5A gene to confirm or exclude a diagnosis of SPG10, distinguish it from other hereditary spastic paraplegia subtypes, and provide reliable information for medical management and genetic counselling.
How to Prepare
- No fasting is required.
- Inform the laboratory if the patient is on anticoagulant therapy.
- FTA card spots should be allowed to air dry before sealing.
- Label the sample clearly with the patient's full name and date of birth.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"If a familial pathogenic KIF5A variant is known, prenatal or preimplantation genetic testing options may be discussed with a genetic counsellor."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or grossly hemolyzed blood sample
- Incorrectly labelled or unlabelled sample
- Inadequate sample volume or insufficient DNA concentration
- Sample received after prolonged storage at room temperature
Understanding Your Results
Pathogenic variant detected
The diagnosis of SPG10 is confirmed. Family members can be offered predictive testing and genetic counselling.
Likely pathogenic variant detected
The result is highly suggestive of SPG10. Further family segregation studies may be advised to confirm clinical significance.
Variant of uncertain significance detected
The clinical significance of the variant is not yet known. Additional testing of family members or functional studies may be recommended.
No pathogenic variant detected
No causative variant was found in the KIF5A gene. Other hereditary spastic paraplegia genes or acquired causes should be considered.
Consult your treating neurologist or genetic counsellor if you have progressive lower limb stiffness or weakness, a family history of hereditary spastic paraplegia, or if your test result shows a variant that requires further explanation and management planning.
Limitations
- ⚠This test is targeted to the KIF5A gene only and may not detect variants in other genes associated with hereditary spastic paraplegia.
- ⚠NGS may not reliably detect large deletions, duplications, or repeat expansions depending on the assay design.
- ⚠Variants of uncertain significance may require additional family studies to clarify their clinical relevance.
- ⚠A negative result does not completely exclude a genetic cause of hereditary spastic paraplegia.
Risks & Considerations
- ●Minor pain or bruising at the blood collection site
- ●Dizziness or light-headedness during blood draw
- ●No significant medical risks associated with the genetic test itself
Interfering Factors
- ●Poor DNA quality or quantity
- ●Sample mix-up or incorrect labelling
- ●PCR inhibitors in the sample
- ●Genetic variants in primer-binding regions may affect amplification
Compare With Similar Tests
| Test | KIF5A Gene SPG10 NGS Genetic Test | |||
|---|---|---|---|---|
| Comparison | KIF5A Gene SPG10 NGS Genetic Test |
Frequently Asked Questions
What is the KIF5A Gene SPG10 NGS Genetic Test?
What sample is required for the KIF5A Gene SPG10 NGS Genetic Test?
Do I need to fast before the test?
How is the test performed?
How long will the reports take?
What is the cost of the KIF5A Gene SPG10 NGS Genetic Test?
What are the symptoms of SPG10?
Can a negative KIF5A test rule out hereditary spastic paraplegia?
Will I receive raw data files with my report?
Is genetic counselling included in the test?
Can family members be tested after a positive result?
Is home sample collection available?
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