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KLF8 Gene Mental retardation non-syndromic NGS Genetic Test

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KLF8 Gene Mental retardation non-syndromic NGS Genetic Test

Short Name: KLF8 Gene Mental Retardation NGS Test

Also known as: KLF8 Gene Test for Intellectual Disability, KLF8 Mutation Analysis, Non-syndromic MR Genetic Test

KLF8 Gene Mental retardation non-syndromic NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood, Extracted DNA, or FTA Card sample samples. Results in Results available in 3-4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the KLF8 Gene Mental Retardation NGS Genetic Test is to detect genetic mutations in the KLF8 gene that cause non-syndromic mental retardation. This helps in confirming diagnosis, understanding the genetic basis of the condition, and providing information for genetic counseling and family planning.

Test Code
1676
Price
₹20,000
Sample Type
Blood, Extracted DNA, or FTA Card sample
Result Time
Results available in 3-4 weeks from sample receipt.
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and consent for genetic testing. Genetic counseling session recommended.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Blood sample will be drawn by a trained phlebotomist or FTA card will be used for collection. Ensure proper identification.

Step 3

Report Delivery

Apply pressure to the puncture site. Resume normal activities. Samples will be transported to the lab.

Timeline: Results available in 3-4 weeks from sample receipt.

Patient Instructions

1
Before the Test:Genetic counseling session recommended to discuss implications. Provide family history and medical records.
2
During the Test:Sample collection and submission to the lab. The test involves NGS sequencing of the KLF8 gene.
3
After the Test:Results reviewed by a geneticist. Follow-up counseling if needed for interpretation and planning.

About This Test

Who Should Get This Test

The purpose of the KLF8 Gene Mental Retardation NGS Genetic Test is to detect genetic mutations in the KLF8 gene that cause non-syndromic mental retardation. This helps in confirming diagnosis, understanding the genetic basis of the condition, and providing information for genetic counseling and family planning.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile equipment for blood collection
  • Label samples correctly with patient details
  • Transport samples at ambient temperature as per lab guidelines

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for KLF8 mutations is crucial for confirming diagnosis and informing family planning decisions for intellectual disability."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, or FTA Card sample
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood samples stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored at -20°C
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results of the KLF8 Gene NGS Test are interpreted by geneticists. A positive result indicates a mutation in the KLF8 gene, which may be the cause of intellectual disability.
Pathogenic variant: Confirms genetic cause of non-syndromic mental retardation
Variant of uncertain significance (VUS): Requires further testing and clinical evaluation
Negative result: No mutation detected, but clinical suspicion may remain; consider other genetic tests
⚠️ When to Consult a Doctor:

If the test is positive, consult a genetic counselor or neurologist for management options. If symptoms persist despite negative results, consider further evaluation or additional genetic testing.

Limitations

  • ⚠May not detect all types of mutations, such as large deletions or duplications
  • ⚠Cannot predict the exact severity of symptoms
  • ⚠Results require clinical correlation and genetic counseling

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection at puncture site
  • ●Psychological impact of genetic results, requiring support and counseling

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Technical errors in sequencing

Compare With Similar Tests

TestKLF8 Gene Mental retardation non-syndromic NGS Genetic TestWhole Exome SequencingChromosomal MicroarrayFMR1 Gene Test for Fragile X SyndromeSHANK3 Gene Test for Autism Spectrum Disorder
ComparisonKLF8 Gene Mental retardation non-syndromic NGS Genetic TestMore comprehensive, covers multiple genes, but higher cost and longer turnaround time.Detects chromosomal abnormalities but not point mutations like in KLF8 gene.Specific to Fragile X Syndrome, which is a common genetic cause of intellectual disability.Targets autism-related genes, may overlap with intellectual disability cases.

Frequently Asked Questions

What is the KLF8 Gene Mental Retardation NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to identify mutations in the KLF8 gene associated with non-syndromic mental retardation or intellectual disability.
Why is this test recommended?
It is recommended for individuals with unexplained intellectual disability, developmental delays, or a family history to diagnose genetic causes and guide management.
How is the test performed?
The test involves collecting a blood, extracted DNA, or FTA card sample, which is then analyzed using NGS technology to sequence the KLF8 gene.
What is the cost of the test in India?
The cost is INR 20000, which includes home sample collection in many cities across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities nationwide.
How long does it take to get results?
Results are typically available within 3 to 4 weeks from the date of sample receipt at the lab.
What do the results mean?
Results can indicate pathogenic mutations (positive), variants of uncertain significance, or negative. Genetic counseling is advised for interpretation.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw. Psychological impact may occur, so counseling support is available.
Can this test be used for prenatal diagnosis?
It is primarily for postnatal diagnosis; for prenatal testing, consult a genetic counselor for appropriate options.
What is the accuracy of the test?
NGS technology provides high accuracy with a mutation detection rate over 99%, but it may not detect all mutation types.
Who should take this test?
Individuals with intellectual disability, developmental delays, or a family history of similar conditions should consider this test.
How to prepare for the test?
No special preparation is needed. Provide clinical history and undergo genetic counseling if recommended before sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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