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LAMB1 Gene Lissencephaly type 5 NGS Genetic Test

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LAMB1 Gene Lissencephaly type 5 NGS Genetic Test

Short Name: LAMB1 Lissencephaly Type 5 Test

Also known as: LAMB1-related lissencephaly, Lissencephaly 5

LAMB1 Gene Lissencephaly type 5 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the LAMB1 Gene Lissencephaly Type 5 NGS Genetic Test is to detect mutations in the LAMB1 gene that cause Lissencephaly Type 5. This test aids in confirming diagnosis, guiding treatment plans, and facilitating genetic counseling for affected families.

Test Code
2748
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or use of FTA card for one drop of blood.

Step 3

Report Delivery

Sample sent to laboratory for analysis; results available in 3-4 weeks.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are required before testing.
2
During the Test:A blood sample is drawn and sent for NGS analysis in the laboratory.
3
After the Test:Results are reviewed by a geneticist, and a report is provided with recommendations.

About This Test

Who Should Get This Test

The purpose of the LAMB1 Gene Lissencephaly Type 5 NGS Genetic Test is to detect mutations in the LAMB1 gene that cause Lissencephaly Type 5. This test aids in confirming diagnosis, guiding treatment plans, and facilitating genetic counseling for affected families.

How to Prepare

  • Ensure proper identification of patient
  • Use sterile collection tubes
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for LAMB1 mutations is crucial for confirming Lissencephaly Type 5, enabling timely intervention and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the LAMB1 gene. A positive result confirms Lissencephaly Type 5, while a negative result may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of Lissencephaly Type 5; genetic counseling recommended.

📊

No pathogenic variant detected

Lissencephaly Type 5 unlikely; consider other genetic or clinical causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

Consult a doctor if a child shows symptoms such as developmental delay, seizures, or microcephaly, or if there is a family history of lissencephaly.

Limitations

  • ⚠May not detect all types of mutations (e.g., large deletions)
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample storage

Compare With Similar Tests

TestLAMB1 Gene Lissencephaly type 5 NGS Genetic TestDCX Gene Lissencephaly TestPAFAH1B1 Gene Lissencephaly TestTUBA1A Gene Lissencephaly TestComprehensive Lissencephaly Panel
ComparisonLAMB1 Gene Lissencephaly type 5 NGS Genetic Test

Frequently Asked Questions

What is Lissencephaly Type 5?
Lissencephaly Type 5 is a rare genetic disorder caused by mutations in the LAMB1 gene, leading to abnormal brain development with a smooth brain surface.
What are the symptoms of Lissencephaly Type 5?
Symptoms include severe developmental delay, poor muscle tone, seizures, microcephaly, intellectual disability, feeding difficulties, and abnormal eye movements.
How is Lissencephaly Type 5 diagnosed?
Diagnosis is confirmed through genetic testing, specifically the NGS Genetic Test that analyzes the LAMB1 gene for mutations.
What is the cost of the LAMB1 Gene Lissencephaly Type 5 NGS Genetic Test?
The test costs INR 20000 at DNA Labs India, with free home sample collection available.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get the results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What should I do if the test result is positive?
A positive result confirms Lissencephaly Type 5; consult a geneticist for management and genetic counseling.
Can this test be used for prenatal diagnosis?
This test is typically for postnatal diagnosis; consult a healthcare provider for prenatal options.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising; psychological counseling may be recommended.
How accurate is the NGS Genetic Test for Lissencephaly Type 5?
The test is highly accurate for detecting pathogenic variants in the LAMB1 gene, but results should be interpreted in clinical context.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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