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LAMC1 Gene Dandy-Walker malformation and occipital cephaloceles, LAMC1 related NGS Genetic Test

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LAMC1 Gene Dandy-Walker malformation and occipital cephaloceles, LAMC1 related NGS Genetic Test

LAMC1 Gene Dandy-Walker malformation and occipital cephaloceles, LAMC1 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next Generation Sequencing (NGS)Pediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the LAMC1 Gene NGS Genetic Test is to detect mutations in the LAMC1 gene that cause Dandy-Walker malformation and occipital cephaloceles. This helps in confirming diagnosis, guiding treatment decisions, assessing recurrence risks for family members, and facilitating genetic counseling. Early identification through genetic testing can improve clinical management and support research into these rare conditions.

Test Code
2715
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with LAMC1-related conditions.

Method: Blood Draw

Step 2

Laboratory Analysis

Your sample is analyzed using Next Generation Sequencing (NGS) in our laboratory.

Step 3

Report Delivery

A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended before testing.
2
During the Test:The test involves Next Generation Sequencing of the LAMC1 gene from a blood or DNA sample.
3
After the Test:Results are available in 3-4 weeks. Follow-up with a genetic specialist is advised for interpretation and management.

About This Test

Who Should Get This Test

The purpose of the LAMC1 Gene NGS Genetic Test is to detect mutations in the LAMC1 gene that cause Dandy-Walker malformation and occipital cephaloceles. This helps in confirming diagnosis, guiding treatment decisions, assessing recurrence risks for family members, and facilitating genetic counseling. Early identification through genetic testing can improve clinical management and support research into these rare conditions.

How to Prepare

  • Collect blood sample using standard venipuncture techniques.
  • Alternatively, use extracted DNA or one drop of blood on an FTA card.
  • Ensure proper labeling and transport to the laboratory.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood Draw

Understanding Your Results

Results from the LAMC1 Gene NGS Genetic Test are interpreted based on the presence or absence of pathogenic mutations in the LAMC1 gene. A positive result indicates a genetic cause for Dandy-Walker malformation or occipital cephaloceles, while a negative result suggests other etiologies may be involved.
Pathogenic variant detected: Confirms genetic diagnosis; genetic counseling recommended for family planning.
No pathogenic variant detected: Reduces likelihood of LAMC1-related cause; consider other genetic or environmental factors.
Variant of uncertain significance: Requires further investigation and family studies; clinical correlation advised.
⚠️ When to Consult a Doctor:

Consult a doctor if symptoms such as developmental delay, movement issues, seizures, or skull abnormalities are present, or if there is a family history of these conditions. Genetic counseling is advised before and after testing.

Limitations

  • ⚠Test may not detect all genetic variants due to technical limitations.
  • ⚠Results require interpretation by a genetic specialist.
  • ⚠Does not rule out other genetic or environmental causes of the conditions.

Risks & Considerations

  • ●Minimal physical risks from blood draw.
  • ●Potential psychological impact from test results.
  • ●Privacy concerns related to genetic data.

Frequently Asked Questions

What is the LAMC1 gene?
The LAMC1 gene encodes laminin, a protein essential for the extracellular matrix, which supports cell structure and nervous system development.
What is Dandy-Walker malformation?
Dandy-Walker malformation is a rare congenital brain condition where the cerebellum is underdeveloped, leading to fluid-filled spaces and symptoms like developmental delay and seizures.
What are occipital cephaloceles?
Occipital cephaloceles are defects in the skull at the back of the head, allowing brain tissue and membranes to protrude, which can cause neurological issues.
How is the LAMC1 gene related to these conditions?
Mutations in the LAMC1 gene disrupt laminin production, impairing nervous system development and causing Dandy-Walker malformation and occipital cephaloceles.
What symptoms indicate the need for this test?
Symptoms include developmental delay, movement coordination problems, seizures, skull abnormalities, or brain tissue protrusions, especially with a family history.
How is the test performed?
The test uses Next Generation Sequencing (NGS) to analyze the LAMC1 gene from a blood sample, extracted DNA, or blood on an FTA card.
What is the cost of the LAMC1 Gene NGS Genetic Test?
The test costs INR 20,000, with free home sample collection available across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What should I do before getting tested?
Before testing, undergo genetic counseling to discuss family history and implications, and provide clinical history of the patient.
What do the test results mean?
Results show if there are mutations in the LAMC1 gene. A positive result confirms a genetic cause; a negative result suggests other factors. Interpretation by a genetic specialist is essential.
Are there any risks associated with the test?
Risks are minimal, such as slight discomfort from blood draw, but potential psychological impacts from results should be considered. Genetic counseling is recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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