LDB3 Gene Myopathy, myofibrillar, ZASP related NGS Genetic Test
Short Name: LDB3 Myopathy NGS Test
Also known as: LDB3-related myopathy genetic test, ZASP-related myopathy NGS test, Myofibrillar myopathy LDB3 gene analysis
LDB3 Gene Myopathy, myofibrillar, ZASP related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued within 3 to 4 weeks after the sample and clinical details are received.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To confirm or rule out a genetic cause of myofibrillar myopathy / ZASP-related myopathy by analysing the LDB3 gene, supporting clinical management, prognosis, and family counseling.
- Test Code
- 4386
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are issued within 3 to 4 weeks after the sample and clinical details are received.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. Please carry any previous muscle biopsy, EMG, nerve conduction study, and cardiac evaluation reports.
Method: Blood draw / FTA card spot / DNA submission
Laboratory Analysis
A small blood sample is collected by venipuncture. Alternatively, an FTA card one-drop blood sample or extracted DNA can be submitted. The procedure is quick and routinely performed.
Report Delivery
You can resume normal activities immediately. There are no post-procedure restrictions.
Timeline: Reports are issued within 3 to 4 weeks after the sample and clinical details are received.
Patient Instructions
About This Test
Who Should Get This Test
To confirm or rule out a genetic cause of myofibrillar myopathy / ZASP-related myopathy by analysing the LDB3 gene, supporting clinical management, prognosis, and family counseling.
How to Prepare
- No fasting required
- Blood sample to be collected in an EDTA vacutainer
- FTA card may be used for one-drop blood collection
- For extracted DNA, submit in a sterile DNA vial with patient details
- Ensure that the patient's clinical questionnaire and consent form are completed
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing should be offered alongside clinical evaluation in patients with suspected myofibrillar myopathy. The identification of a pathogenic LDB3 variant enables targeted screening for cardiac and respiratory complications and allows accurate recurrence-risk counseling for the family."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient quantity of sample
- Sample in wrong container
- Missing patient identification or clinical history
- Sample expired beyond storage stability
Understanding Your Results
No evidence of a disease-causing LDB3 gene variant in this analysis. Other genetic or non-genetic causes of myopathy should be considered.
Molecular confirmation of LDB3-related myopathy. Genetic counseling and family segregation testing are recommended.
Insufficient evidence to classify the variant as pathogenic or benign. Additional family studies or functional data may be needed.
If you have progressive muscle weakness, unsteady gait, difficulty breathing or swallowing, palpitations, or a family history of myopathy, you should consult a neurologist or clinical geneticist for evaluation.
Limitations
- ⚠NGS may not detect all large structural rearrangements
- ⚠Deep intronic variants, repetitive regions, and homopolymer sequences may be challenging
- ⚠This test is targeted to the LDB3 gene and is not a whole-genome screen
- ⚠A variant of uncertain significance may require additional family studies
- ⚠Results should be interpreted in the context of clinical and family history
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the needle site
- ●Dizziness or fainting during blood collection
- ●Very low risk of infection at the puncture site
Interfering Factors
- ●Low-quality DNA due to sample degradation
- ●Contamination during sample collection
- ●Recent allogeneic blood transfusion may dilute patient DNA
- ●Bone marrow transplantation associated chimerism
- ●Variants in regions not adequately covered by NGS
Frequently Asked Questions
What is LDB3 gene myopathy?
What does the LDB3 NGS genetic test detect?
Who should undergo this test?
What is the cost of the LDB3 gene myopathy NGS genetic test?
What type of sample is required?
Do I need to fast before the test?
How long does it take to get reports?
Will I receive raw sequencing data?
Can this test predict the severity of the disease?
What does a negative result mean?
How are variants of uncertain significance (VUS) handled?
Is home sample collection available?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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