LGI1 Gene Epilepsy, familial temporal lobe type 1 NGS Genetic Test
Short Name: LGI1 Gene Epilepsy NGS Test
Also known as: LGI1 gene mutation analysis, LGI1 gene sequencing test, Familial temporal lobe epilepsy type 1 genetic test
LGI1 Gene Epilepsy, familial temporal lobe type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks after the sample is received at the laboratory. Raw data, FASTQ, and VCF files are provided with the final clinical report.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify a pathogenic variant in the LGI1 gene in a person with clinical features of familial temporal lobe epilepsy type 1, to support diagnosis, inform recurrence risks, and guide genetic counselling for affected families.
- Test Code
- 4077
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks after the sample is received at the laboratory. Raw data, FASTQ, and VCF files are provided with the final clinical report.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. Please carry valid identification and any previous epilepsy evaluation reports. If a familial LGI1 variant is already known, provide a copy of the affected relative's report. A genetic counselling session may be recommended to document family history and draw a pedigree.
Method: Venepuncture or FTA card blood spot
Laboratory Analysis
A trained phlebotomist will collect a blood sample in an EDTA tube, or a few drops of blood will be placed on an FTA card, depending on the test request.
Report Delivery
No restrictions are needed after collection. You can resume normal activities immediately. The sample will be processed at the laboratory, and the report is expected within 3 to 4 weeks.
Timeline: 3 to 4 weeks after the sample is received at the laboratory. Raw data, FASTQ, and VCF files are provided with the final clinical report.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify a pathogenic variant in the LGI1 gene in a person with clinical features of familial temporal lobe epilepsy type 1, to support diagnosis, inform recurrence risks, and guide genetic counselling for affected families.
How to Prepare
- Use an EDTA vacutainer for whole blood collection.
- If using an FTA card, apply one drop of blood and allow it to air-dry completely.
- Label the sample clearly with the patient name, date of collection, and clinical indication.
- Do not freeze whole blood; protect the sample from direct sunlight and extreme heat during transport.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A pathogenic LGI1 variant gives clarity for family counselling and enables predictive testing in asymptomatic relatives. In an individual with clear focal epilepsy, genetic diagnosis should not delay appropriate seizure treatment."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolysed or clotted blood sample
- Insufficient blood volume for DNA extraction
- FTA card not dried before sealing in the pouch
- Incorrectly labelled sample or missing clinical details
- Sample exposed to extreme heat or repeated freeze-thaw cycles
Understanding Your Results
Negative
No pathogenic or likely pathogenic variant was detected in the LGI1 gene. This does not exclude non-genetic causes of epilepsy or variants in other epilepsy genes.
Positive
A pathogenic or likely pathogenic variant was detected in LGI1. This supports a diagnosis of LGI1-related familial temporal lobe epilepsy type 1 and allows predictive testing of at-risk family members.
Variant of Uncertain Significance (VUS)
A variant was detected but its clinical significance is not yet known. Family segregation studies and additional clinical data may be required.
Consult a neurologist if you have recurrent seizures, unexplained loss of awareness, memory problems, confusion, or speech difficulty. If a familial LGI1 variant has been identified, consult a clinical geneticist for predictive testing and family planning guidance.
Limitations
- ⚠This targeted test analyzes only the LGI1 gene and does not rule out other genetic causes of epilepsy.
- ⚠NGS may not reliably detect large deletions, duplications, deep intronic variants, or repeat expansions unless specifically validated.
- ⚠A negative result does not exclude non-genetic causes of seizures or variants in other epilepsy genes.
- ⚠Variant of uncertain significance (VUS) may require additional family segregation studies before clinical action.
Risks & Considerations
- ●No significant physical risks; there is a small risk of mild pain, bruising, or bleeding at the blood draw site.
- ●Low risk of vasovagal episode during blood collection.
- ●Potential psychological impact of a positive, negative, or uncertain genetic result.
Interfering Factors
- ●Previously known familial pathogenic variant not provided to the laboratory may limit interpretation.
- ●Low DNA yield or degraded DNA can lead to sequencing failure or incomplete coverage.
- ●Clinical misclassification: if the epilepsy phenotype is not consistent with LGI1-related epilepsy, results may be difficult to interpret.
Compare With Similar Tests
| Test | LGI1 Gene Epilepsy, familial temporal lobe type 1 NGS Genetic Test | EEG | MRI Brain | LGI1 NGS Genetic Test |
|---|---|---|---|---|
| Comparison | LGI1 Gene Epilepsy, familial temporal lobe type 1 NGS Genetic Test | Records electrical brain activity and helps localize seizure focus, but it cannot identify the underlying LGI1 gene mutation. | Detects structural abnormalities such as hippocampal sclerosis or cortical malformations. A normal MRI does not exclude genetic epilepsy. | Analyzes DNA to identify a specific pathogenic variant in LGI1 and provides a molecular diagnosis when clinical and imaging findings are non-diagnostic. |
Frequently Asked Questions
What is the LGI1 gene NGS genetic test?
What is the cost of this test?
What sample is required?
Do I need to fast before the test?
How long will the report take?
Who should consider this test?
Does a positive result confirm epilepsy?
What does a negative LGI1 result mean?
Can this test replace EEG or MRI?
Will I receive raw data files?
Is home sample collection available?
Does insurance cover this genetic test?
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