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DNA Labs India

LGMD NGS Panel Test

DNA Labs India | ISO 9001:2015 Certified

LGMD NGS Panel Test

Also known as: LGMD Genetic Panel, Limb-Girdle Muscular Dystrophy NGS Panel, Muscular Dystrophy Genetic Test

LGMD NGS Panel Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation on Blood samples. Results in Results are typically available within 21-28 days after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.. Free home collection in 300+ cities across India.

NGS PanelAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The primary purpose of the LGMD NGS Panel is to identify the specific genetic mutation responsible for LGMD in an individual. This information is crucial for confirming the diagnosis, determining the subtype, predicting disease progression, and enabling informed reproductive decisions. The panel also helps differentiate LGMD from other neuromuscular disorders with similar clinical presentations, such as Becker muscular dystrophy or inflammatory myopathies. By providing a definitive genetic diagnosis, the test facilitates personalized treatment plans, including appropriate physical therapy, respiratory support, and cardiac monitoring. Additionally, it allows for cascade testing of family members and prenatal diagnosis in affected families.

Test Code
6299
CPT Code
81408
ICD Code
G71.0
Price
₹20,000
Sample Type
Blood
Result Time
Results are typically available within 21-28 days after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.
Fasting Required
No
Method
Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation
Step 1

Sample Collection

No special preparation is required. Inform your doctor about any medications or supplements you are taking. Avoid blood transfusion for at least 2 weeks prior to the test if possible.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.

Step 3

Report Delivery

You may resume normal activities immediately. There is no special care required after the blood draw.

Timeline: Results are typically available within 21-28 days after the sample reaches the laboratory. You will be notified via email or SMS when the report is ready.

Patient Instructions

1
Before the Test:No special preparation is required. However, inform your doctor about any medications, supplements, or recent blood transfusions.
2
During the Test:A blood sample is collected from a vein in your arm. The process takes only a few minutes.
3
After the Test:You can resume normal activities immediately. There are no restrictions.

About This Test

Who Should Get This Test

The primary purpose of the LGMD NGS Panel is to identify the specific genetic mutation responsible for LGMD in an individual. This information is crucial for confirming the diagnosis, determining the subtype, predicting disease progression, and enabling informed reproductive decisions. The panel also helps differentiate LGMD from other neuromuscular disorders with similar clinical presentations, such as Becker muscular dystrophy or inflammatory myopathies. By providing a definitive genetic diagnosis, the test facilitates personalized treatment plans, including appropriate physical therapy, respiratory support, and cardiac monitoring. Additionally, it allows for cascade testing of family members and prenatal diagnosis in affected families.

How to Prepare

  • No fasting required
  • Inform the lab if you have had a blood transfusion in the past 2 weeks
  • Ensure the sample is collected in an EDTA tube
  • Keep the sample at room temperature if delivered within 24 hours; otherwise refrigerate

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early genetic confirmation of LGMD is crucial for prognosis and family counseling. This panel covers all major LGMD subtypes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume3-5 mL
ContainerEDTA (purple top) tube
Collection MethodVenipuncture

Sample Stability

Whole blood in EDTA: stable for 48 hours at 2-8°C
Do not freeze whole blood
Extracted DNA: stable for months at -20°C
Sample Rejection Criteria:
  • Hemolyzed sample
  • Clotted sample
  • Incorrect tube (e.g., heparin tube)
  • Sample received after 72 hours without proper storage
  • Insufficient volume

Understanding Your Results

The LGMD NGS Panel report will identify any pathogenic or likely pathogenic variants in the analyzed genes. The interpretation is based on current medical literature and databases. A positive result confirms the genetic diagnosis of LGMD and specifies the subtype. A negative result reduces the likelihood of a genetic cause in the tested genes but does not exclude LGMD entirely. Variants of uncertain significance (VUS) may be reported and require further family studies or functional analysis.
📊

Positive (Pathogenic variant found)

Confirms LGMD diagnosis; enables subtype-specific management and family testing

📊

Negative (No pathogenic variant found)

LGMD due to tested genes is unlikely; consider other genetic or acquired causes

📊

Variant of Uncertain Significance (VUS)

Further testing of family members or additional functional studies may be needed

⚠️ When to Consult a Doctor:

Consult your doctor if you experience progressive muscle weakness, difficulty climbing stairs, or frequent falls. Early referral to a neurologist or geneticist is recommended for proper evaluation and testing.

Limitations

  • ⚠This panel does not detect all possible genetic causes of LGMD; some rare genes may not be included
  • ⚠Variants of uncertain significance (VUS) may be reported and require further investigation
  • ⚠NGS may not detect large structural variants or repeat expansions
  • ⚠Negative results do not completely rule out LGMD; other genetic or non-genetic causes may be considered
  • ⚠Genetic counseling is recommended to interpret results in the context of family history

Risks & Considerations

  • ●Minimal risk of bruising or bleeding at the puncture site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Recent blood transfusion may cause mixed DNA results
  • ●Bone marrow transplantation can affect genetic results
  • ●Contamination of sample with foreign DNA
  • ●Insufficient DNA quantity or quality
  • ●Presence of large deletions/duplications not detected by NGS alone

Compare With Similar Tests

TestLGMD NGS PanelSingle Gene TestingMuscle BiopsyCreatine Kinase (CK) Test
ComparisonLGMD NGS PanelTargets one gene based on clinical suspicion. Less comprehensive, may miss other subtypes. Cost is lower but may require multiple tests.Invasive procedure that provides protein analysis but cannot identify the specific genetic mutation. Useful when genetic testing is inconclusive.A blood test that indicates muscle damage but is not specific to LGMD. Elevated CK may prompt genetic testing.

Frequently Asked Questions

What is the cost of the LGMD NGS Panel at DNA Labs India?
The LGMD NGS Panel costs INR 20000. This includes the genetic analysis of 39 genes, interpretation, and a detailed report. Free home sample collection is provided for online bookings.
What sample is required for the LGMD NGS Panel?
A blood sample is required. The test uses 3-5 mL of blood collected in an EDTA (purple top) tube.
Do I need to fast before the LGMD NGS Panel?
No, fasting is not required for this test. You can eat and drink normally before the blood draw.
How long does it take to get the results?
The turnaround time is typically 21-28 days from the date the sample is received at the laboratory. This allows for comprehensive sequencing and analysis.
Which genes are included in the LGMD NGS Panel?
The panel analyzes 39 genes associated with Limb-Girdle Muscular Dystrophy, including CAPN3, DYSF, SGCA, SGCB, SGCG, SGCD, FKRP, LMNA, TTN, ANO5, and others.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across major cities in India. The phlebotomist will visit your location at a convenient time.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, including children. However, genetic counseling is recommended before testing minors.
What does a positive result mean?
A positive result indicates that a pathogenic variant was found in one of the tested genes, confirming the genetic diagnosis of LGMD. This helps in subtype-specific management and family planning.
What does a negative result mean?
A negative result means no pathogenic variants were found in the tested genes. This reduces the likelihood of LGMD due to these genes, but other genetic or acquired causes may still be considered.
Are there any risks associated with the test?
The test involves a routine blood draw, which carries minimal risks such as slight bruising or discomfort at the puncture site. There are no significant health risks.
Is genetic counseling provided?
Yes, DNA Labs India provides genetic counseling as part of the test package. Our geneticists will help you understand the results and their implications for you and your family.
Is the test covered by insurance?
Insurance coverage varies by provider and policy. We recommend checking with your insurance company. DNA Labs India does not directly bill insurance, but we provide necessary documentation for reimbursement.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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