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DNA Labs India

Limb-girdle muscular dystrophy (LGMD) Test

DNA Labs India | ISO 9001:2015 Certified

Limb-girdle muscular dystrophy (LGMD) Test

Short Name: LGMD Panel

Also known as: LGMD Genetic Test, Muscular Dystrophy Panel, LGMD NGS Panel

Limb-girdle muscular dystrophy (LGMD) Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in Reports are typically delivered within 21 days from sample receipt.. Free home collection in 300+ cities across India.

NGS Gene PanelAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify pathogenic mutations in genes associated with limb-girdle muscular dystrophy. It aids in confirming a clinical diagnosis, differentiating LGMD from other neuromuscular disorders, determining the specific subtype, and providing information for genetic counseling and family planning. The test also helps in predicting disease progression and guiding management strategies.

Test Code
6310
CPT Code
81408
ICD Code
G71.0
Price
₹20,000
Sample Type
Blood
Result Time
Reports are typically delivered within 21 days from sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. However, it is essential to provide clinical indications and family history. Please bring any previous test reports (EMG, muscle biopsy, CK levels) if available.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm. The procedure is quick and routine.

Step 3

Report Delivery

You can resume normal activities immediately. No restrictions are necessary.

Timeline: Reports are typically delivered within 21 days from sample receipt.

Patient Instructions

1
Before the Test:No special preparation. Ensure you have your clinical history and any prior test results.
2
During the Test:A simple blood draw is performed. It takes about 5 minutes.
3
After the Test:You can leave immediately. Results will be available in 21 days.

About This Test

Who Should Get This Test

The purpose of this test is to identify pathogenic mutations in genes associated with limb-girdle muscular dystrophy. It aids in confirming a clinical diagnosis, differentiating LGMD from other neuromuscular disorders, determining the specific subtype, and providing information for genetic counseling and family planning. The test also helps in predicting disease progression and guiding management strategies.

How to Prepare

  • No fasting required
  • Inform the lab if you have had a blood transfusion in the past 3 months
  • Provide accurate clinical and family history
  • Ensure correct patient identification

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for LGMD is crucial for accurate diagnosis, prognosis, and family planning. Early identification of the specific gene mutation can guide management and reproductive decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume3-5 mL
ContainerEDTA (purple top) tube
Collection MethodVenipuncture

Sample Stability

Room temperature24 hours
Refrigerated (2-8°C)72 hours
Frozen (-20°C)1 week
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Incorrect anticoagulant tube
  • Insufficient sample volume
  • Sample received after prolonged transit time without proper storage
  • Mislabeled or unlabeled sample

Understanding Your Results

The results of this NGS panel are interpreted by a clinical geneticist. The report will indicate whether any pathogenic or likely pathogenic variants were identified in the tested genes. If a variant is found, the report will include its clinical significance, inheritance pattern, and implications for the patient and family.
📊

Positive (pathogenic variant detected)

Confirms the diagnosis of LGMD. The specific gene and variant will be reported. Genetic counseling is recommended for family members.

📊

Negative (no pathogenic variant detected)

No mutation found in the tested genes. This does not rule out LGMD; other genetic or non-genetic causes may be considered. Further testing may be advised.

📊

Variant of Uncertain Significance (VUS)

A genetic variant was found, but its clinical significance is unknown. Additional testing of family members may help clarify. Genetic counseling is essential.

⚠️ When to Consult a Doctor:

Consult your doctor if you experience progressive muscle weakness, difficulty climbing stairs, frequent falls, or difficulty lifting objects. Early referral to a neurologist or geneticist is recommended for proper evaluation.

Limitations

  • ⚠This panel covers only the listed genes; mutations in other LGMD-associated genes may not be detected
  • ⚠Variant of uncertain significance (VUS) may be reported, requiring further segregation analysis
  • ⚠Large deletions/duplications may not be detected by NGS alone; additional testing may be needed
  • ⚠Negative result does not exclude LGMD if clinical suspicion is high; other genes or non-genetic causes should be considered
  • ⚠Genetic counseling is recommended for interpretation of results

Risks & Considerations

  • ●Minimal risk of bruising or infection at the needle site
  • ●Possible anxiety or discomfort during blood draw
  • ●Psychological impact of genetic results
  • ●Risk of incidental findings (unrelated genetic variants)

Interfering Factors

  • ●Recent blood transfusion may dilute patient DNA, affecting results
  • ●Bone marrow transplantation can lead to mixed DNA profiles
  • ●Contamination of sample with foreign DNA
  • ●Insufficient DNA quantity or quality
  • ●Presence of large deletions/duplications not detected by standard NGS

Compare With Similar Tests

TestLimb-girdle muscular dystrophy (LGMD)Single Gene TestingWhole Exome SequencingMuscle Biopsy
ComparisonLimb-girdle muscular dystrophy (LGMD)Targets one specific gene based on clinical suspicion. Less comprehensive, may miss other subtypes.Sequences all coding regions of the genome. More comprehensive but higher cost and longer turnaround.Invasive procedure examining muscle tissue. Can show dystrophic changes but not specific to LGMD subtype.

Frequently Asked Questions

What is Limb-girdle muscular dystrophy (LGMD)?
LGMD is a group of inherited muscle disorders causing progressive weakness and wasting of the proximal muscles (hips and shoulders). It is caused by mutations in various genes affecting muscle proteins.
What genes are tested in this LGMD panel?
This panel tests for mutations in SGCA, SGCB, SGCD, SGCG, and FKRP genes, which are commonly associated with LGMD subtypes.
What is the cost of the LGMD genetic test at DNA Labs India?
The test costs INR 20,000, which includes genetic counseling, NGS sequencing, and a comprehensive report.
Is fasting required for this test?
No, fasting is not required. You can eat and drink normally before the test.
What sample is needed for the test?
A blood sample (3-5 mL) collected in an EDTA tube is required.
How long does it take to get results?
The turnaround time is 21 days from the date of sample receipt.
Is home sample collection available?
Yes, we offer free home sample collection for online bookings across major cities in India.
What does a positive result mean?
A positive result indicates the presence of a pathogenic mutation in one of the tested genes, confirming the diagnosis of LGMD. Genetic counseling is recommended.
What if the result is negative?
A negative result means no mutation was found in the tested genes. It does not completely rule out LGMD; other genetic or non-genetic causes may be considered.
Can this test be used for carrier testing?
Yes, this test can be used for carrier testing in individuals with a family history of LGMD, especially for autosomal recessive forms.
Is genetic counseling included?
Yes, the price includes genetic counseling before and after the test to help you understand the implications.
Which cities are covered for home sample collection?
We provide home sample collection in over 200 cities including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, and many more.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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