LINS1 Gene Mental retardation, autosomal recessive type 27 NGS Genetic Test
Short Name: LINS1 MRT27 NGS
Also known as: LINS1 Gene Mutation Test, MRT27 NGS Genetic Test, Autosomal Recessive Type 27 Intellectual Disability Genetic Test
LINS1 Gene Mental retardation, autosomal recessive type 27 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued within 3 to 4 weeks from the date of sample receipt at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic mutations in the LINS1 gene, which are linked to autosomal recessive type 27 mental retardation (MRT27). The test confirms the clinical diagnosis, helps assess recurrence risk in families, and supports genetic counselling for affected individuals and their relatives.
- Test Code
- 4255
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are issued within 3 to 4 weeks from the date of sample receipt at the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. Please inform your healthcare provider about any medications or supplements you are taking. A genetic counselling session may be arranged before sample collection.
Method: Blood Draw or FTA Spot
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. For FTA card sampling, a small drop of blood from a finger prick is applied onto the card. The procedure is quick and minimally discomforting.
Report Delivery
You may resume normal activities immediately. The sample will be transported to our laboratory under optimum conditions for NGS analysis.
Timeline: Reports are issued within 3 to 4 weeks from the date of sample receipt at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic mutations in the LINS1 gene, which are linked to autosomal recessive type 27 mental retardation (MRT27). The test confirms the clinical diagnosis, helps assess recurrence risk in families, and supports genetic counselling for affected individuals and their relatives.
How to Prepare
- No special preparation such as fasting is required.
- For blood sample, use an EDTA tube.
- For FTA card, one drop of blood is sufficient.
- Ensure the sample is clearly labelled with patient details.
- Home sample collection can be scheduled at your convenience.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic counselling is essential for families with intellectual disability to understand the inheritance pattern, recurrence risk, and implications of LINS1 gene mutations. Early diagnosis through NGS enables proactive management and family planning decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
- Clotted or haemolysed blood sample
- Inadequate sample volume
- Improperly labelled sample
- Sample received after prolonged storage at incorrect temperature
Understanding Your Results
No pathogenic variant detected
No mutation in the LINS1 gene was identified. This does not rule out other genetic or non-genetic causes of intellectual disability.
Pathogenic variant detected
The diagnosis of LINS1-related MRT27 is confirmed. Autosomal recessive inheritance is indicated; genetic counselling is strongly recommended.
Variant of uncertain significance (VUS)
A variant was found but its clinical significance is currently unclear. Additional testing or family segregation analysis may be needed.
If you or your family member has symptoms such as intellectual disability, speech delay, learning difficulties, or behavioural issues, it is advisable to consult a neurologist, geneticist, or clinical genetics professional for evaluation and appropriate genetic testing.
Limitations
- ⚠This test specifically detects mutations in the LINS1 gene and does not exclude other genetic or environmental causes of intellectual disability.
- ⚠Results should be interpreted in the context of clinical findings and family history.
Risks & Considerations
- ●Mild bruising or pain at blood drawing site
- ●Lightheadedness or dizziness
- ●Rare risk of infection or excessive bleeding
Frequently Asked Questions
What is LINS1 gene mental retardation?
What is the cost of the LINS1 gene NGS genetic test?
How is the LINS1 gene NGS genetic test performed?
What sample is required for this test?
Is fasting required for the LINS1 gene NGS test?
How long does it take to get the report?
Is home sample collection available?
Who should take this test?
What is the role of genetic counselling in this test?
When is this test recommended by a doctor?
Does this test detect all genetic causes of intellectual disability?
Is this test covered by health insurance?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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